SARS-CoV-2 and its ACE2 receptor

The SARS-CoV-2 virus enters the human host cell via the receptor ACE2 and uses the serine protease TMPRSS2 for S protein priming. The ACE2 usage has been shown to be crucial for transmissibility of other coronaviruses. Much research into the COVID-19 pandemic focuses on understanding the complex process of virus entry.

January 13, 2021

Neuroinvasion of SARS-CoV-2 in human and mouse brain

The Journal of Experimental Medicine
Eric SongAkiko Iwasaki
January 11, 2021

Endothelial cells and SARS-CoV-2: An intimate relationship

Vascular Pharmacology
Lucas Cunha BarbosaValéria Pereira Ferrer
January 13, 2021

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

Nature Communications
Jiwan GeLinqi Zhang
January 10, 2021

Circulating cardiovascular microRNAs in critically ill COVID-19 patients Short title: microRNA signatures in COVID-19

European Journal of Heart Failure
Ankita GargThomas Thum
January 12, 2021

SARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development

Expert Review of Clinical Pharmacology
Chiranjib ChakrabortyGovindasamy Agoramoorthy
January 11, 2021
Preprint
Open Access

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2 and heparan sulfate

BioRxiv : the Preprint Server for Biology
E. Prieto-FernandezAsis Palazon
January 11, 2021

Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung

Environmental Research
Tomoya SagawaHirohisa Takano
January 12, 2021
Preprint
Open Access

Altered kidney function and acute kidney damage markers predict survival outcomes of COVID-19 patients: A prospective pilot study.

MedRxiv : the Preprint Server for Health Sciences
Mustafa Zafer TemizA. Y. Muslumanoglu
January 12, 2021

ACE2-derived peptides interact with the RBD domain of SARS-CoV-2 spike glycoprotein, disrupting the interaction with the human ACE2 receptor

Journal of Biomolecular Structure & Dynamics
Pedro F N SouzaCleverson D T Freitas
January 11, 2021

Human SARS CoV-2 spike protein mutations

Proteins
Lalitha Guruprasad
January 9, 2021
Open Access

Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

Journal of Translational Medicine
Abul Bashar Mir Md Khademul IslamA M A M Zonaed Siddiki
January 12, 2021
Review

Friend or Foe? ACE2 inhibitors and GLP-1R agonists in COVID-19 treatment

Obesity Medicine
Juan PangTianru Jin
January 11, 2021
Preprint
Open Access

Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment

BioRxiv : the Preprint Server for Biology
M. H. ChengIvet Bahar
January 12, 2021

Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections

Journal of Biomolecular Structure & Dynamics
Chavan SakshiV Veena
January 12, 2021
Review

Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients

Reviews in Medical Virology
Mohammad Mahmudur RahmanAsif Ahmed
January 10, 2021

Expression of SARS-CoV-2 entry factors in human oral tissue

Journal of Anatomy
Yoshihiko SawaHiroyuki Harada

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