SARS-CoV-2 and its ACE2 receptor

The SARS-CoV-2 virus enters the human host cell via the receptor ACE2 and uses the serine protease TMPRSS2 for S protein priming. The ACE2 usage has been shown to be crucial for transmissibility of other coronaviruses. Much research into the COVID-19 pandemic focuses on understanding the complex process of virus entry.

January 21, 2022
Open Access

Overexpression of the SARS-CoV-2 receptor angiotensin converting enzyme 2 in cardiomyocytes of failing hearts.

Scientific Reports
Kristina VukusicOla Hammarsten
January 21, 2022

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies.

Nature Medicine
Laura A VanBlarganMichael S Diamond
January 21, 2022

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants.

Nature Chemical Biology
Lianghui ZhangAsrar B Malik
January 21, 2022
Review

COVID-19 and gut immunomodulation.

World Journal of Gastroenterology : WJG
Koushik RoyPrabhat K Purbey
January 21, 2022
Open Access

Up State of the SARS-COV-2 Spike Homotrimer Favors an Increased Virulence for New Variants.

Frontiers in Medical Technology
Carolina Corrêa GironFernando Luís Barroso da Silva
January 21, 2022
Open Access

Laboratory manifestations and pathophysiological aspects of coronavirus disease 2019 pandemic: focusing on the digestive system.

European Journal of Gastroenterology & Hepatology
Michail GalanopoulosChristos Liatsos
January 21, 2022

Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection.

Environmental Science & Technology
Xiaoting JinGuibin Jiang
January 21, 2022

Molecular docking of phytochemical compounds of Momordica charantia as potential inhibitor against SARS-CoV-2.

Infectious Disorders Drug Targets
Yayu Mulsiani EvaryYusnita Rifai
January 21, 2022
Open Access

Renin Angiotensin System Blockers and Risk of Mortality in Hypertensive Patients Hospitalized for COVID-19: An Italian Registry.

Journal of Cardiovascular Development and Disease
Fabio AngeliTiziana Bachetti
January 21, 2022

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.

Science
Dhiraj MannarSriram Subramaniam
January 21, 2022
Preprint
Open Access

SARS-CoV-2 induces human endogenous retrovirus type W envelope protein expression in blood lymphocytes and in tissues of COVID-19 patients.

MedRxiv : the Preprint Server for Health Sciences
B. CharvetHerve JF Perron
January 20, 2022
Preprint
Open Access

Targeting SARS-CoV-2 infection through CAR T cells and bispecific T cell engagers

BioRxiv : the Preprint Server for Biology
M. DoganDerya Unutmaz
January 20, 2022
Preprint
Open Access

Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 Spike protein

BioRxiv : the Preprint Server for Biology
H. CaohuyHarvey B Pollard
January 20, 2022
Preprint
Open Access

SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epithelium

BioRxiv : the Preprint Server for Biology
M. M. LamersBart L Haagmans
January 20, 2022
Preprint
Open Access

NRP1 and furin as putative mediators of SARS-CoV-2 entry into human brain cells

BioRxiv : the Preprint Server for Biology
Ashutosh KumarP. Prasoon
January 20, 2022
Preprint
Open Access

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants

BioRxiv : the Preprint Server for Biology
J. B. WeinsteinFikadu G Tafesse
January 19, 2022
Preprint
Open Access

High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses

BioRxiv : the Preprint Server for Biology
J. J. SimsJames M Wilson

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