Senotherapeutics

Senotherapeutics, which selectively kill senescent cells (senolytics) or to suppress the senescence-associated secretory phenotype (SASP) that drives sterile inflammation associated with ageing (senomorphics), have been implicated to be novel strategy for aging intervention applicable to promote healthy aging and to prevent or treat age-related diseases

June 21, 2020
Open Access

Identification of longevity compounds with minimized probabilities of side effects

Biogerontology
Georges E Janssens, Riekelt H Houtkooper
July 10, 2020
Open Access

Use of CAR T cells as senolytic agents

Nature Reviews. Nephrology
Ellen F Carney
August 3, 2020
Open Access

Rapid senescence-like response after acute injury

Aging Cell
Xiaogang ChuRaghavan Pillai Raju
June 28, 2020

Senolytic CAR T Cells Targeting uPAR Treat Lung Cancer in Mice

Cancer Discovery
June 14, 2020
Open Access

Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

Aging
Tania VielJulie K Andersen
July 9, 2020
Review
Open Access

Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging

Marine Drugs
Vincenzo SorrentiDonald C Willcox
July 3, 2020
Preprint
Open Access

Senescent cell death as an aging resistance mechanism in naked mole-rat

BioRxiv : the Preprint Server for Biology
Y. KawamuraKyoko Miura
July 4, 2020
Open Access

Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Mio YamaneKazuo Tsubota
June 27, 2020
Review
Open Access

Reducing Senescent Cell Burden in Aging and Disease

Trends in Molecular Medicine
Robert J PignoloJames L Kirkland
July 14, 2020

Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells

Journal of Cellular Physiology
Seo Rin KimLilach O Lerman
June 13, 2020
Open Access

BET family protein degraders poised to join the senolytic arsenal

Signal Transduction and Targeted Therapy
Zufeng GuoYongmei Xie
June 17, 2020
Review

Senescence as a therapeutically relevant response to CDK4/6 inhibitors

Oncogene
Verena Wagner, Jesús Gil
July 16, 2020
Open Access

Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence

Annals of the Rheumatic Diseases
George BatshonMona Dvir-Ginzberg
July 30, 2020
Review

Rising from the ashes: cellular senescence in regeneration

Current Opinion in Genetics & Development
Hannah E Walters, Maximina H Yun
June 21, 2020
Review
Open Access

Terpenoids as Potential Geroprotectors

Antioxidants
Ekaterina ProshkinaAlexey Moskalev
June 14, 2020
Review
Open Access

From causes of aging to death from COVID-19

Aging
Mikhail V Blagosklonny

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