Senotherapeutics

Senotherapeutics, which selectively kill senescent cells (senolytics) or to suppress the senescence-associated secretory phenotype (SASP) that drives sterile inflammation associated with ageing (senomorphics), have been implicated to be novel strategy for aging intervention applicable to promote healthy aging and to prevent or treat age-related diseases

November 27, 2020

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis

Osteoarthritis and Cartilage
Zhenxuan ShaoXiaolei Zhang
December 29, 2020
Review
Open Access

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

Frontiers in Pharmacology
Jie XuYouhua Liu
December 17, 2020
Review
Open Access

Fibroblast Senescence in Idiopathic Pulmonary Fibrosis

Frontiers in Cell and Developmental Biology
Yifan Lin, Zhihao Xu
December 22, 2020
Open Access

Targeting Alternative Splicing for Reversal of Cellular Senescence in the Context of Aesthetic Aging

Plastic and Reconstructive Surgery
Laura R Bramwell, Lorna W Harries
January 8, 2021
Review
Open Access

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

Cancer Management and Research
Chenxi LiaoLingbo Liu
January 14, 2021
Review

Senescence under appraisal: hopes and challenges revisited

Cellular and Molecular Life Sciences : CMLS
Camilla S A Davan-WettonTrinidad Montero-Melendez
January 16, 2021

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

Science
Yoshikazu JohmuraMakoto Nakanishi
December 19, 2020
Review
Open Access

Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria

Frontiers in Physiology
Ying FanLijian Shao
December 16, 2020
Review
Open Access

The Interaction of Viruses with the Cellular Senescence Response

Biology
Rocío SeoaneCarmen Rivas
December 3, 2020
Review
Open Access

Senescence and the SASP: many therapeutic avenues

Genes & Development
Jodie Birch, Jesús Gil
December 23, 2020
Review

Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging

The Journal of Investigative Dermatology
Eleni FitsiouMarco Demaria
December 10, 2020
Open Access

Functional integrity of aging skin, from cutaneous biology to anti-aging strategies

Médecine sciences : M/S
Julie RorteauJérôme Lamartine
December 31, 2020
Review
Open Access

Cell Senescence in Neuropathology: a Focus on Neurodegeneration and Tumours

Neuropathology and Applied Neurobiology
Gabriela CarrenoJuan Pedro Martinez-Barbera
January 15, 2021

Aberrant induction of a mesenchymal/stem-cell program engages senescence in normal mammary epithelial cells

Molecular Cancer Research : MCR
Benjamin L BrysonMark W Jackson
December 31, 2020
Review
Open Access

Is exercise a senolytic medicine? A systematic review

Aging Cell
Xiang-Ke ChenRaymond Chuen-Chung Chang
December 2, 2020
Review
Open Access

Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma

Cells
Constanze MittermeierSusanne Muehlich
December 10, 2020
Preprint
Open Access

Analysis of cellular senescence in gingival tissues and gingival fibroblast cultures

ResearchSquare
Masae FurukawaKenji Matsushita

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