sGC Modulators

Soluble guanylate cyclase (sGC) stimulators and activators have been developed to treat patients with pulmonary hypertension and heart failure, respectively. Recently these sGC modulators have been explored for the treatment of fibrosis. Discover the latest research on sGC modulators here.

January 15, 2021

Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment

Proceedings of the National Academy of Sciences of the United States of America
Stephanie ConstantinSusan Wray
January 9, 2021
Open Access

Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders

Molecular Psychiatry
Sébastien Delhaye, Barbara Bardoni
January 17, 2021
Open Access

The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling

Molecular & Cellular Proteomics : MCP
Bokai SongIleana M Cristea
January 16, 2021

Tadalafil Reversed H-89 - and Scopolamine - Induced Spatial Learning Impairments in Male Rats

Drug Research
Kaveh TabrizianSahar Fanoudi
January 7, 2021
Open Access

A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

Cell Reports
Hong SunFei Guo
January 7, 2021
Open Access

Loss of cGMP-dependent protein kinase II alters ultrasonic vocalizations in mice, a model for speech impairment in human microdeletion 4q21 syndrome

BioRxiv : the Preprint Server for Biology
T. M. TranSeonil Kim
January 22, 2021

Differential gene expression patterns in spermatozoa from teratospermic and normospermic domestic cats.

Animal Reproduction Science
Audra A HuffmeyerRobert K Wayne
January 20, 2021

CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload-Induced Heart Failure

Circulation. Heart Failure
Daniel A RichardsRobert M Blanton
January 6, 2021

Molecular Properties and Optogenetic Applications of Enzymerhodopsins

Advances in Experimental Medicine and Biology
Satoshi P TsunodaHideki Kandori
January 23, 2021

Novel Insights Regarding Nitric Oxide and Cardiovascular Diseases.

Teresa InfanteClaudio Napoli
January 4, 2021
Open Access

The year in cardiovascular medicine 2020: heart failure and cardiomyopathies

European Heart Journal
Héctor BuenoJohann Bauersachs
January 20, 2021

Interventional and pharmacological management of chronic thromboembolic pulmonary hypertension.

Respiratory Medicine
Hossein-Ardeschir GhofraniGérald Simonneau
January 5, 2021
Open Access

Porcine Circovirus Type 3 Cap Inhibits Type I Interferon Induction Through Interaction With G3BP1

Frontiers in Veterinary Science
Pengfei ZhangChangxu Song
January 19, 2021

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

ACS Biomaterials Science & Engineering
Changjiang PanWei Ye
January 7, 2021

A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats

Cell Biology and Toxicology
Sonia TarazonaVicente Felipo
January 15, 2021

Lead and mercury 28 day exposure at small concentrations reduces smooth muscle relaxation by decreasing cGMP

Toxicology and Applied Pharmacology
Bárbara Ahnert Blanco de Moura MagalhãesMaylla Ronacher Simões

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