Signaling Pathways in Glioblastoma

Glioblastoma is a malignant brain tumor with mutations in various signaling pathways involved in tumorigenic processes. Developing therapeutic agents against these signaling pathways are ongoing. Discover the latest research on signaling pathways in glioblastoma.

November 10, 2020

RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.

Experimental and Molecular Pathology
Haitao FanQi Pang
November 20, 2020

Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products

Biochemical Pharmacology
Yuying WangJing Li
January 23, 2021
Review

Targeting protein kinases for anti-glioma treatment.

Folia Neuropathologica
Emanuela Pucko, Robert Ostrowski
December 31, 2020
Open Access

TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma

Cancers
Michela CampoloEmanuela Esposito
November 26, 2020
Open Access

Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma

Neuro-oncology Advances
Karisa C SchreckChristine A Pratilas
October 30, 2020
Open Access

TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L

BMC Biology
Derek WongStephen Yip
January 13, 2021
Review
Open Access

The role of E3 ubiquitin ligases in the development and progression of glioblastoma

Cell Death and Differentiation
Luke M HumphreysVincenzo D'Angiolella
November 13, 2020

Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review

Current Medicinal Chemistry
Amir R AfshariAmirhossein Sahebkar
January 8, 2021
Open Access

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.

The Journal of Biological Chemistry
Catherine A HurdDarerca Owen
November 12, 2020
Open Access

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

Nature Communications
Jason V GregoryJoerg Lahann
January 8, 2021

Guanabenz Sensitizes Glioblastoma Cells to Sunitinib by Inhibiting GADD34-Mediated Autophagic Signaling

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Kuo-Hao HoKu-Chung Chen
October 29, 2020

Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.

Molecular Carcinogenesis
Toshihide MatsumotoMakoto Saegusa

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