Signaling Pathways in Glioblastoma

Glioblastoma is a malignant brain tumor with mutations in various signaling pathways involved in tumorigenic processes. Developing therapeutic agents against these signaling pathways are ongoing. Discover the latest research on signaling pathways in glioblastoma.

November 10, 2020

RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.

Experimental and Molecular Pathology
Haitao FanQi Pang
November 20, 2020

Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products

Biochemical Pharmacology
Yuying WangJing Li
January 23, 2021

Targeting protein kinases for anti-glioma treatment.

Folia Neuropathologica
Emanuela Pucko, Robert Ostrowski
December 31, 2020
Open Access

TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma

Michela CampoloEmanuela Esposito
November 26, 2020
Open Access

Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma

Neuro-oncology Advances
Karisa C SchreckChristine A Pratilas
October 30, 2020
Open Access

TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L

BMC Biology
Derek WongStephen Yip
January 13, 2021
Open Access

The role of E3 ubiquitin ligases in the development and progression of glioblastoma

Cell Death and Differentiation
Luke M HumphreysVincenzo D'Angiolella
November 13, 2020

Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review

Current Medicinal Chemistry
Amir R AfshariAmirhossein Sahebkar
January 8, 2021
Open Access

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.

The Journal of Biological Chemistry
Catherine A HurdDarerca Owen
November 12, 2020
Open Access

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

Nature Communications
Jason V GregoryJoerg Lahann
January 8, 2021

Guanabenz Sensitizes Glioblastoma Cells to Sunitinib by Inhibiting GADD34-Mediated Autophagic Signaling

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Kuo-Hao HoKu-Chung Chen
October 29, 2020

Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.

Molecular Carcinogenesis
Toshihide MatsumotoMakoto Saegusa

Sign up to follow this feed and discover related papers.

Related Feeds


This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.

G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.

Glia & Synaptic Circuits

Glial cells within the brain, particularly astrocytes and microglia, support synaptic transmission and neuron-glial circuit through the secretion of signaling molecules. The network of communication between glial cells and neurons is highly complex yet organized. Here is the latest research on glia and synaptic circuits.

Hypothalamus & Feeding

The hypothalamus has received significant attention in this regard given its ability to influence feeding behavior, yet organisms rely on a much broader diversity and distribution of neuronal networks to regulate both energy intake and expenditure. Here is the latest research on the hypothalamus and feeding.

Molecular Organization of Synapses

This feed focuses on the molecular organization of synapses between two nerve cells, synaptic signal transduction, and synaptic vesicles. Here is the latest research on organization of synapses.

Myelin Formation & Repair

Myelin surrounds axons and is important for efficient axonal function. Formation of myelin is regulated by many signaling pathways. Degeneration can result in multiple diseases such as multiple sclerosis, and regeneration is associated with oligodendrocyte progenitor cells. Here is the latest research on myelin formation and repair.

NMDA Receptor Signaling

The NDMA receptor is an ionotropic receptor that is activated when glutamate or glycine binds to it, initiating several downstream signaling cascades. NDMA receptor signaling is thought to be implicated in different pathologies, including depression. Here is the latest research on NDMA receptor signaling.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

© 2021 Meta ULC. All rights reserved