Single-Cell RNA Sequencing: Kidney and Organoids

Single-cell RNA sequencing of the adult human kidney transcriptome can provide molecular information about cell-specific responses to environmental variables and disease states. This information can provide a dataset to benchmark human kidney organoids. Discover the latest research on adult kidney organoids at single cell resolution here.

October 21, 2020
Open Access

Single-cell transcriptomics: a new research technique for precision medicine in nephrology

The Korean Journal of Internal Medicine
Jisoo Kim, Jihwan Park
August 21, 2020

A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs

Biochemical and Biophysical Research Communications
Tatsuya ShimizuKenji Osafune
August 25, 2020
Review
Open Access

Differentiating Induced Pluripotent Stem Cells into Renal Cells: A New Approach to Treat Kidney Diseases

Stem Cells International
Patrícia de Carvalho RibeiroHeloisa Cristina Caldas
November 12, 2020

Decoding myofibroblast origins in human kidney fibrosis

Nature
Christoph KuppeRafael Kramann
September 26, 2020
Open Access

Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy

The Korean Journal of Internal Medicine
Jin Won KimYong Kyun Kim
November 17, 2020
Open Access

Molecular detection of maturation stages in the developing kidney

Developmental Biology
Hidekazu NaganumaRyuichi Nishinakamura
August 21, 2020

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Cell Stem Cell
Yi MiaoK Christopher Garcia
August 14, 2020
Review

Modeling oncogenic herpesvirus infections in humanized mice

Current Opinion in Virology
Philip T Lange, Blossom Damania
October 31, 2020

A human tissue screen identifies a regulator of ER secretion as a brain size determinant

Science
Christopher EskJürgen A Knoblich
August 6, 2020

Successful Introduction of Human Renovascular Units into the Mammalian Kidney

Journal of the American Society of Nephrology : JASN
Oren PleniceanuShoshana Greenberger
September 20, 2020
Review

Single-Cell Sequencing in Genitourinary Malignancies

Advances in Experimental Medicine and Biology
Neal MurphyAnnette Lee
September 2, 2020
Preprint
Open Access

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

BioRxiv : the Preprint Server for Biology
Y. GUANGary Peltz
September 13, 2020
Open Access

Human kidney organoids produce functional renin

Kidney International
Anusha S ShankarMartin J Hoogduijn
September 20, 2020

Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo

Cell Metabolism
Satotaka OmoriMakoto Nakanishi
August 29, 2020
Preprint
Open Access

Human relevance of blocking the Rac1-TRPC5 pathway as a podocyte-protective strategy for progressive kidney diseases

BioRxiv : the Preprint Server for Biology
Y. ZhouAnna Greka
September 19, 2020
Open Access

A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors

Cell Reports
Manvendra SinghCédric Feschotte
November 10, 2020
Preprint
Open Access

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

BioRxiv : the Preprint Server for Biology
X. ShengKatalin Susztak
November 12, 2020
Preprint
Open Access

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

BioRxiv : the Preprint Server for Biology
B. A. GoodsLauren H Sansing
November 17, 2020
Preprint
Open Access

Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition

BioRxiv : the Preprint Server for Biology
T. GeuensV. L. S. LaPointe

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