Spatiotemporal Multi-Organ Developmental Maps

The aim of the Spatiotemporal Multi-Organ Developmental Map Project is to build an atlas of an individual’s organ development program by applying single cell sequencing and 4i spatial maps to primary tissue and matched iPSC-derived organoids. Find the latest research pertaining to these techniques here.

August 23, 2020
Open Access

Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons

Nature Communications
Pietro Giuseppe MazzaraVania Broccoli
August 21, 2020

A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs

Biochemical and Biophysical Research Communications
Tatsuya ShimizuKenji Osafune
August 25, 2020
Review
Open Access

Differentiating Induced Pluripotent Stem Cells into Renal Cells: A New Approach to Treat Kidney Diseases

Stem Cells International
Patrícia de Carvalho RibeiroHeloisa Cristina Caldas
August 8, 2020
Review
Open Access

In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid

Archives of Pharmacal Research
Ki Hong NamJaecheol Lee
September 12, 2020
Open Access

Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A

Stem Cell Reports
Dilara SenAlbert J Keung
August 23, 2020
Preprint
Open Access

Modeling Genetic Epileptic Encephalopathies using Brain Organoids

BioRxiv : the Preprint Server for Biology
D. J. SteinbergRami I. Aqeilan
September 26, 2020

Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy

The Korean Journal of Internal Medicine
Jin Won KimYong Kyun Kim
September 15, 2020

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Journal of Visualized Experiments : JoVE
Georgia PennarossaTiziana A L Brevini
September 20, 2020
Open Access

Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung

Stem Cells Translational Medicine
Shaun M KunisakiJason R Spence
August 26, 2020
Open Access

iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2

ACS Chemical Neuroscience
Xiao-Yuan Mao, Wei-Lin Jin
September 26, 2020
Open Access

The Use of Induced Pluripotent Stem Cells as a Model for Developmental Eye Disorders

Frontiers in Cellular Neuroscience
Jonathan EintrachtMariya Moosajee
September 12, 2020

One-step synthesis of composite hydrogel capsules to support liver organoid generation from hiPSCs

Biomaterials Science
Yaqing WangJianhua Qin
August 14, 2020
Open Access

Origin of the Induced Pluripotent Stem Cells Affects Their Differentiation into Dopaminergic Neurons

International Journal of Molecular Sciences
Paula ChlebanowskaMarcin Majka
August 22, 2020

Multi-walled carbon nanotubes decrease neuronal NO synthase in 3D brain organoids

The Science of the Total Environment
Ying JiangYi Cao
September 2, 2020
Review
Open Access

iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative Medicine

International Journal of Molecular Sciences
Cristina OlgasiAntonia Follenzi
September 13, 2020
Open Access

Human kidney organoids produce functional renin

Kidney International
Anusha S ShankarMartin J Hoogduijn
August 29, 2020
Preprint
Open Access

Human relevance of blocking the Rac1-TRPC5 pathway as a podocyte-protective strategy for progressive kidney diseases

BioRxiv : the Preprint Server for Biology
Y. ZhouAnna Greka

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