Spinocerebellar Ataxia: miRNAs

microRNAs (miRNAs) are key regulatory RNAs that control gene expression in various biological processes and human diseases such as Spinocerebellar Ataxia. Here are the latest discoveries pertaining to miRNAs and this disease.

April 27, 2017
Review
Open Access

Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions

Frontiers in Cellular Neuroscience
Adam CiesiolkaWlodzimierz J Krzyzosiak
December 13, 2016
Review
Open Access

Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms

Biochimica Et Biophysica Acta. Molecular Cell Research
Rawan EidMichael T Greenwood
June 7, 2016
Review
Open Access

Hypo- and Hyper-Assembly Diseases of RNA-Protein Complexes

Trends in Molecular Medicine
Siddharth Shukla, Roy Parker
August 22, 2017
Review

Spinocerebellar ataxia: miRNAs expose biological pathways underlying pervasive Purkinje cell degeneration

Neurobiology of Disease
Rogier van der StijlD S Verbeek
June 25, 2014
Open Access

Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice

RNA
Reema RoshanBeena Pillai
December 3, 2014
Open Access

miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3

FEBS Letters
Fengzhen HuangHong Jiang
October 13, 2014
Open Access

Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7

Nature Structural & Molecular Biology
Jennifer Y TanAna C Marques
March 28, 2017
Open Access

Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31

Neuron
Taro IshiguroKinya Ishikawa
April 26, 2015

MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2

The Cerebellum
Lena Constantin, Brandon J Wainwright
February 24, 2016
Open Access

Lifespan and reproduction in brain-specific miR-29-knockdown mouse

Biochemical and Biophysical Research Communications
Toru Takeda, Hiroyuki Tanabe
October 18, 2016

Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis

Journal of Neurology & Neuromedicine
Robert C A M van Waardenburg
June 24, 2014
Open Access

Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression

Molecular Cell
Moe YokoshiYukio Kawahara
July 15, 2016
Open Access

An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron

Science Translational Medicine
Yu MiyazakiChristopher M Gomez
August 28, 2015
Open Access

NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation

ELife
Vincenzo A GennarinoHuda Y Zoghbi
August 4, 2015
Review
Open Access

Epigenetics and therapeutic targets mediating neuroprotection

Brain Research
Irfan A Qureshi, Mark F Mehler
August 5, 2017
Open Access

microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells

Journal of Neuroinflammation
Reema RoshanBeena Pillai
October 23, 2015
Open Access

Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy

Brain : a Journal of Neurology
Megan S KeiserBeverly L Davidson

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