Spinocerebellar Ataxia: miRNAs

microRNAs (miRNAs) are key regulatory RNAs that control gene expression in various biological processes and human diseases such as Spinocerebellar Ataxia. Here are the latest discoveries pertaining to miRNAs and this disease.

December 9, 2021

MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3.

Nucleic Acid Therapeutics
Rui Jorge NobreLodewijk J Toonen
October 28, 2021
Open Access

Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system.

Brain Communications
Marina Sogorb-GonzalezAstrid Vallès
October 20, 2021

Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain.

Nature Medicine
Megan S KeiserBeverly L Davidson
June 17, 2021
Review

Making sense of mRNA landscapes: Translation control in neurodevelopment.

Wiley Interdisciplinary Reviews. RNA
Yongkyu ParkMladen-Roko Rasin
March 22, 2021
Open Access

Staufen1 in Human Neurodegeneration.

Annals of Neurology
Sharan PaulStefan M Pulst
December 20, 2020
Review
Open Access

Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases.

International Journal of Molecular Sciences
Leticia Moreno-GarcíaRosario Osta
September 3, 2020
Review
Open Access

UTteR control through miRs: fine-tuning ATXN1 levels to prevent ataxia.

Genes & Development
Mingyi Xie, Maurice S Swanson
August 30, 2020
Open Access

PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells.

Molecular Neurobiology
Sabine C WinklerJosef P Kapfhammer
August 9, 2020
Open Access

miR760 regulates ATXN1 levels via interaction with its 5' untranslated region.

Genes & Development
Larissa NitschkeHuda Y Zoghbi
July 30, 2020

Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons.

Neuropathology and Applied Neurobiology
Masahiro SatoTakahiro Seki
July 9, 2020
Open Access

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

Molecular Therapy. Methods & Clinical Development
Josse A DeplaMelvin M Evers
December 13, 2019
Open Access

Development of an AAV-Based MicroRNA Gene Therapy to Treat Machado-Joseph Disease

Molecular Therapy. Methods & Clinical Development
Raygene MartierMelvin M Evers
July 6, 2019
Open Access

The Emerging Role of microRNAs in Polyglutamine Diseases

Frontiers in Molecular Neuroscience
Xiaoyu Dong, Shuyan Cong
June 13, 2019
Open Access

State biomarkers for Machado Joseph disease: Validation, feasibility and responsiveness to change

Genetics and Molecular Biology
Gabriel Vasata FurtadoLaura Bannach Jardim
March 14, 2019
Open Access

Modeling Neurodegenerative Spinocerebellar Ataxia Type 13 in Zebrafish Using a Purkinje Neuron Specific Tunable Coexpression System

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Kazuhiko NamikawaReinhard W Köster
February 6, 2019

Wide Profiling of Circulating MicroRNAs in Spinocerebellar Ataxia Type 7

Molecular Neurobiology
Verónica M Borgonio-CuadraJonathan J Magaña
January 22, 2019
Review
Open Access

The Role of MicroRNAs in Spinocerebellar Ataxia Type 3

Journal of Molecular Biology
Sybille Krauß, Bernd O Evert

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