Stem Cell Aging

Aging tissues experience a progressive decline in homeostatic and regenerative capacities, which has been attributed to degenerative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem cell activity. Understanding the molecular pathways involved in this age-dependent deterioration of stem cell function will be critical for developing new therapies for diseases of aging that target the specific causes of age-related functional decline.

January 9, 2021
Open Access

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

ACS Chemical Neuroscience
Debasis PatnaikStephen J Haggarty
January 2, 2021
Open Access

NAD+ metabolism, stemness, the immune response, and cancer

Signal Transduction and Targeted Therapy
Lola E Navas, Amancio Carnero
January 14, 2021
Open Access

P- cresol and Indoxyl Sulfate Impair Osteogenic Differentiation by Triggering Mesenchymal Stem Cell Senescence

International Journal of Medical Sciences
Witchayapon KampromAungkura Supokawej
January 16, 2021
Open Access

Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

International Journal of Molecular Sciences
Kenneth K Wu
January 8, 2021
Open Access

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

Science Translational Medicine
Wei WangGuang-Hui Liu
January 6, 2021
Open Access

Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators

International Journal of Molecular Sciences
Eva SernaJose Vina
January 15, 2021

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity

Amanda AmoahHartmut Geiger
January 10, 2021
Open Access

Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma

International Journal of Molecular Sciences
Mutharasu GnanavelMeenakshisundaram Kandhavelu
January 8, 2021
Open Access

Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

Frontiers in Cell and Developmental Biology
Chunhua JiangFangliang Zhang
January 5, 2021
Open Access

Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function

The Journal of Clinical Investigation
Maegan L CapitanoHal E Broxmeyer
January 13, 2021
Open Access

Cell Fitness: More Than Push-Ups

International Journal of Molecular Sciences
Adam James FerrariRajan Gogna
January 14, 2021

Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

Cell Reports
Charles ArberSelina Wray

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