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STING Receptor Agonists

STING Receptor Agonists diagram by 2013MMG230E, Wikimedia
2013MMG230E, Wikimedia

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Top 20 most recent papers
Nature Reviews. Genetics

DNA sensing by the cGAS-STING pathway in health and disease

Nature Reviews. GeneticsJuly 31, 2019
Mona MotwaniKatherine A Fitzgerald
162
6
301
Proceedings of the National Academy of Sciences of the United States of America

PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response

Proceedings of the National Academy of Sciences of the United States of AmericaSeptember 19, 2019
Tian XiaHong-Bing Shu
1
The Journal of Immunology : Official Journal of the American Association of Immunologists

Assembling the Inflammasome, Piece by Piece

The Journal of Immunology : Official Journal of the American Association of ImmunologistsAugust 21, 2019
Fiachra Humphries, Katherine A Fitzgerald
13
1
9
The Journal of Immunology : Official Journal of the American Association of Immunologists

A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome

The Journal of Immunology : Official Journal of the American Association of ImmunologistsDecember 15, 2019
Ankit BhattaKatherine A Fitzgerald
92
Nature

Design of amidobenzimidazole STING receptor agonists with systemic activity

NatureNovember 9, 2018
Joshi M RamanjuluJohn Bertin
388
2
3
285
1
The Journal of Immunology : Official Journal of the American Association of Immunologists

TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge

The Journal of Immunology : Official Journal of the American Association of ImmunologistsDecember 29, 2019
Mor Gross-VeredSteffen Jung
7
The Journal of Experimental Medicine

Gasdermins and their role in immunity and inflammation

The Journal of Experimental MedicineSeptember 25, 2019
Pontus OrningKatherine A Fitzgerald
40
2
41
Medicinal Research Reviews

Agonists and inhibitors of the STING pathway: Potential agents for immunotherapy

Medicinal Research ReviewsDecember 4, 2019
Jun-Jun WuYan-Mei Li
2
The Journal of Clinical Investigation

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

The Journal of Clinical InvestigationDecember 19, 2018
Yongsheng YuXianxian Zhao
9
1
38
Cell

Toll-like Receptors and the Control of Immunity

CellMarch 14, 2020
Katherine A Fitzgerald, Jonathan C Kagan
195
1
Proceedings of the National Academy of Sciences of the United States of America

Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunity

Proceedings of the National Academy of Sciences of the United States of AmericaMarch 28, 2020
Alexander H MorrisonRobert H Vonderheide
3
Science Immunology

NK cells mediate clearance of CD8+ T cell-resistant tumors in response to STING agonists

Science ImmunologyMarch 22, 2020
Christopher J NicolaiDavid H Raulet
117
Cell Reports

Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2

Cell ReportsNovember 8, 2018
Roland EllingSusan Carpenter
51
5
62
1

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