STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

May 28, 2019
Open Access

HiChIRP reveals RNA-associated chromosome conformation

Nature Methods
Maxwell R MumbachHoward Y Chang
March 6, 2020

Direct binding to NLRP3 pyrin domain is a novel strategy to prevent NLRP3-driven inflammation and gouty arthritis

Arthritis & Rheumatology
Gabsik YangJoo Y Lee
October 11, 2019
Open Access

STING signaling is a potential immunotherapeutic target in colorectal cancer

Journal of Cancer
Hong Jae ChonChan Kim
May 18, 2020

PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA

Cellular & Molecular Immunology
Chen-Yang LiaoHong-Bing Shu
September 19, 2019
Open Access

PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response

Proceedings of the National Academy of Sciences of the United States of America
Tian XiaHong-Bing Shu
July 20, 2019
Open Access

MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling

Cell Communication and Signaling : CCS
Engin BaturcamDanen Mootoosamy Cunoosamy
November 24, 2019
Review
Open Access

Bioactive modulators targeting STING adaptor in cGAS-STING pathway

Drug Discovery Today
Xi FengJinlei Bian
August 1, 2020
Open Access

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Nature Communications
Jesse J BalicAshley Mansell
July 17, 2020

STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

Science Translational Medicine
Cameron S BaderRobert B Levy
September 13, 2019

SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA

Cellular & Molecular Immunology
Wei GuoQing Yang
February 11, 2020
Open Access

Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection

Frontiers in Cellular and Infection Microbiology
Federica AglianoAndrei E Medvedev
June 26, 2020
Review

Long non-coding RNAs in antiviral immunity

Seminars in Cell & Developmental Biology
Tim Vierbuchen, Katherine A Fitzgerald
August 8, 2019

The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding

Cellular & Molecular Immunology
Xuan ZhongHong-Bing Shu
June 2, 2020
Open Access

Pharmacological STING Activation Is a Potential Alternative to Overcome Drug-Resistance in Melanoma

Frontiers in Oncology
Sandhya ChipurupalliNirmal Robinson
May 24, 2019
Open Access

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Nature
Baoyu ZhaoPingwei Li
October 5, 2019
Open Access

Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice

Scientific Reports
Gary R MartinFrank R Jirik
August 21, 2019
Open Access

Assembling the Inflammasome, Piece by Piece

The Journal of Immunology : Official Journal of the American Association of Immunologists
Fiachra Humphries, Katherine A Fitzgerald
July 30, 2019
Review
Open Access

STING pathway agonism as a cancer therapeutic

Immunological Reviews
Blake A FloodThomas F Gajewski

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