STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

November 29, 2021

Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die.

Journal of Molecular Biology
Natalia Ketelut-Carneiro, Katherine A Fitzgerald
October 28, 2021
Open Access

UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis.

PloS One
Hera KimRichard K Kandasamy
September 16, 2021

Author Correction: ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response.

Nature Communications
Huan LianHong-Bing Shu
August 18, 2021
Comment / Editorial

Igniting the firestorm: The inflammasome in autoinflammatory syndromes.

The Journal of Allergy and Clinical Immunology
Fiachra Humphries, Katherine A Fitzgerald
June 25, 2021

Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.

Proceedings of the National Academy of Sciences of the United States of America
Yongzhi ChenKatherine A Fitzgerald
March 20, 2021
Open Access

Lung Epithelial Cell Transcriptional Regulation as a Factor in COVID-19-associated Coagulopathies.

American Journal of Respiratory Cell and Molecular Biology
Ethan S FitzGeraldAmanda M Jamieson
January 5, 2021

Overcoming innate immune barriers that impede AAV gene therapy vectors.

The Journal of Clinical Investigation
Manish MuhuriGuangping Gao
December 15, 2020
Open Access

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.

Nature Communications
Shiuli AgarwalKatherine A Fitzgerald
November 19, 2020
Open Access

Ensuring vaccine safety

David M KnipeElke Mühlberger
November 5, 2020
Open Access

Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria

Nature Communications
Larissa M N PereiraRicardo T Gazzinelli
September 16, 2020
Open Access

Caspase-8 mediates inflammation and disease in rodent malaria.

Nature Communications
Larissa M N PereiraRicardo T Gazzinelli
August 21, 2020

Succination inactivates gasdermin D and blocks pyroptosis.

Fiachra HumphriesKatherine A Fitzgerald

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