STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

December 29, 2020
Review

STING, a promising target for small molecular immune modulator: A review

European Journal of Medicinal Chemistry
Yijun LiuHaopeng Sun
March 6, 2020

Direct binding to NLRP3 pyrin domain is a novel strategy to prevent NLRP3-driven inflammation and gouty arthritis

Arthritis & Rheumatology
Gabsik YangJoo Y Lee
December 15, 2020
Open Access

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

Nature Communications
Shiuli AgarwalKatherine A Fitzgerald
May 18, 2020

PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA

Cellular & Molecular Immunology
Chen-Yang LiaoHong-Bing Shu
August 1, 2020
Open Access

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Nature Communications
Jesse J BalicAshley Mansell
July 17, 2020

STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

Science Translational Medicine
Cameron S BaderRobert B Levy
August 10, 2020
Open Access

Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Vuk BortnikAdi Idris
August 12, 2020
Preprint
Open Access

A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

BioRxiv : the Preprint Server for Biology
M. C. KiritsyAndrew Olive
February 11, 2020
Open Access

Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection

Frontiers in Cellular and Infection Microbiology
Federica AglianoAndrei E Medvedev
June 26, 2020
Review

Long non-coding RNAs in antiviral immunity

Seminars in Cell & Developmental Biology
Tim Vierbuchen, Katherine A Fitzgerald
January 5, 2021
Review

Overcoming innate immune barriers that impede AAV gene therapy vectors

The Journal of Clinical Investigation
Manish MuhuriGuangping Gao
September 16, 2020
Open Access

Caspase-8 mediates inflammation and disease in rodent malaria

Nature Communications
Larissa M N PereiraRicardo T Gazzinelli
June 2, 2020
Open Access

Pharmacological STING Activation Is a Potential Alternative to Overcome Drug-Resistance in Melanoma

Frontiers in Oncology
Sandhya ChipurupalliNirmal Robinson
November 25, 2020
Comment / Editorial

Loosening the grip on nuclear cGAS

Nature Genetics
Fiachra Humphries, Katherine A Fitzgerald
August 21, 2020

Succination inactivates gasdermin D and blocks pyroptosis

Science
Fiachra HumphriesKatherine A Fitzgerald
October 22, 2020
Review
Open Access

Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy

Journal of Clinical Medicine
Leila Motedayen AvalDavid J Pinato
November 19, 2020
Open Access

Ensuring vaccine safety

Science
David M KnipeElke Mühlberger
May 21, 2020

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9

Nature
Leonhard X HeinzGiulio Superti-Furga
January 4, 2021
Preprint
Open Access

Low STING expression in a transplantable KrasG12D/P53ko lung cancer model contributes to SiglecF+ neutrophil and CD103+Treg accumulation in tumors

BioRxiv : the Preprint Server for Biology
L. GrosJulien Faget

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