Structure of GPCR

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research on structures of these receptors.

February 14, 2021
Open Access

How μ-opioid receptor recognizes fentanyl.

Nature Communications
Quynh N VoChristopher R Ellis
February 7, 2021
Open Access

Structural and functional analysis of Ccr1l1, a Rodentia-restricted eosinophil-selective chemokine receptor homologue.

The Journal of Biological Chemistry
Jaclyn M KlineSergio M Pontejo
February 6, 2021
Open Access

A general method for quantifying ligand binding to unmodified receptors using Gaussia luciferase.

The Journal of Biological Chemistry
András Dávid TóthLászló Hunyady
February 3, 2021
Open Access

That was then, this is now: the development of our knowledge and understanding of P2 receptor subtypes.

Purinergic Signalling
Charles Kennedy
February 1, 2021
Open Access

Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila.

The Journal of Biological Chemistry
Qiuxiang GuJunhai Han
February 1, 2021
Open Access

The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.

The Journal of Biological Chemistry
Qiang WangVladlen Z Slepak
February 2, 2021
Open Access

Probing thermostability of detergent-solubilized CB2 receptor by parallel G protein-activation and ligand-binding assays.

The Journal of Biological Chemistry
Ryan L BecknerAlexei A Yeliseev
February 2, 2021
Open Access

Angiotensin II increases activity of the ClC-K2 Cl- channel in collecting duct intercalated cells by stimulating production of reactive oxygen species.

The Journal of Biological Chemistry
Naghmeh Hassanzadeh KhayyatOleh Pochynyuk
January 30, 2021
Review
Open Access

Heterotrimeric Gq proteins as therapeutic targets?

The Journal of Biological Chemistry
Evi KostenisSuvi Annala
January 28, 2021
Review
Open Access

Structure, Function, and Pharmaceutical Ligands of 5-Hydroxytryptamine 2B Receptor.

Pharmaceuticals
Qing WangNiu Huang
January 27, 2021
Open Access

Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2.

International Journal of Molecular Sciences
Sabina PodlewskaJadwiga Handzlik
January 27, 2021
Open Access

Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.

The Journal of Biological Chemistry
Maxime GagnonFernand Gobeil
January 26, 2021
Open Access

The single nucleotide β -arrestin2 variant, A248T, resembles dynamical properties of activated arrestin.

Turkish Journal of Chemistry
Özge Şensoy

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