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Structure of GPCR

Structure of GPCR diagram by

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research on structures of these receptors.

Top 20 most recent papers
Journal of the American Chemical Society

Direct Observation of Symmetry-Dependent Electron-Phonon Coupling in Black Phosphorus

Journal of the American Chemical SocietyNovember 7, 2019
Nannan MaoJing Kong
Nature Communications

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

Nature CommunicationsDecember 8, 2019
Anastasiia GusachVadim Cherezov
Journal of Medicinal Chemistry

Comparison of orexin 1 and orexin 2 ligand binding modes using X-ray crystallography and computational analysis

Journal of Medicinal ChemistryDecember 21, 2019
Mathieu RappasJohn A Christopher

α1A-adrenoceptor inverse agonists and agonists modulate receptor signalling through a conformational selection mechanism

bioRxivDecember 7, 2019
Paul R GooleyDaniel J. Scott
Scientific Reports

Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts

Scientific ReportsNovember 9, 2019
Patrick ErnstAndreas Plückthun
Scientific Reports

Unravelling Receptor and RGD Motif Dependence of Retargeted Adenoviral Vectors using Advanced Tumor Model Systems

Scientific ReportsDecember 8, 2019
M ChernyavskaW P R Verdurmen

Crystal and cryo-EM structures of the cytosolic G protein alpha chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

bioRxivJanuary 5, 2020
Levi J. McClellandStephen R. Sprang
Cell Reports

Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor

Cell ReportsDecember 5, 2019
Xiaoyu ChenGuisheng Zhong
Inorganic Chemistry

In Situ Metal-Ligand Reactions under Solvent-Dependent Hydro(solvo)thermal Conditions: Structures, Mass Spectrometry, and Magnetism

Inorganic ChemistryDecember 7, 2019
Ye TaoFu-Ping Huang
Organic Letters

Herpotrichones A and B, Two Intermolecular [4 + 2] Adducts with Anti-Neuroinflammatory Activity from a Herpotrichia Species

Organic LettersDecember 25, 2019
Wen-Bo HanJin-Ming Gao
FEBS Open Bio

Crystal structure of botulinum neurotoxin subtype A3 cell binding domain in complex with GD1a co-receptor ganglioside

FEBS Open BioJanuary 17, 2020
Kyle S GregoryK Ravi Acharya
Inorganic Chemistry

Versatile {Cp2 Ti} Grafted Hetero-Polyoxotungstate Clusters: Synthesis, Crystal Structure, and Photocurrent Properties

Inorganic ChemistryJanuary 4, 2020
Vikram SinghJingyang Niu
European Journal of Medicinal Chemistry

Substituted 4-phenylthiazoles: Development of potent and selective A1 , A3 and dual A1 /A3 adenosine receptor antagonists

European Journal of Medicinal ChemistryNovember 30, 2019
Aliaa AbdelrahmanChrista E Müller
Journal of Medicinal Chemistry

Docking finds GPCR ligands in dark chemical matter

Journal of Medicinal ChemistryDecember 18, 2019
Flavio BallanteJens Carlsson
Biochimica Et Biophysica Acta. Biomembranes

Detergent-free extraction of a functional low-expressing GPCR from a human cell line

Biochimica Et Biophysica Acta. BiomembranesDecember 18, 2019
Juan Francisco Bada JuarezAnthony Watts
The Journal of Biological Chemistry

Molecular basis for activation and biased signalling at the thrombin-activated GPCR Proteinase Activated Receptor-4 (PAR4)

The Journal of Biological ChemistryJanuary 2, 2020
Pierre E ThibeaultRithwik Ramachandran
Communications Biology

Crystal structure of human endothelin ETB receptor in complex with peptide inverse agonist IRL2500

Communications BiologyJanuary 12, 2020
Chisae NagiriOsamu Nureki
Archiv der Pharmazie

G protein-coupled receptor binding and pharmacological evaluation of indole-derived thiourea compounds

Archiv der PharmazieNovember 30, 2019
Daniel SzulczykMarta Struga

Isotactic Polybutene-1/Bamboo Powder Composites with Excellent Properties at Initial Stage of Molding

PolymersDecember 8, 2019
Bo WangYing-Hui Wei
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

The important role of N(2)(CH3)4 ion in the phase transition mechanism of N(CH3)42ZnBr4

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency ControlJanuary 4, 2020
A Kiraci

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