Structure of GPCR

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research on structures of these receptors.

September 13, 2020

Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ecto-phospholipase C acting as an endocannabinoid signaling switch

The Journal of Biological Chemistry
Fabienne Briand-MésangeHugues Chap
July 15, 2020
Preprint
Open Access

A structural model of a Ras-Raf signalosome

BioRxiv : the Preprint Server for Biology
V. P. MysoreDavid E. Shaw
August 14, 2020
Open Access

The chemokine X-factor: structure-function analysis of the CXC motif at CXCR4 and ACKR3

The Journal of Biological Chemistry
Michael J WedemeyerBrian F Volkman
August 26, 2020
Preprint
Open Access

How μ -Opioid Receptor Recognizes Fentanyl

BioRxiv : the Preprint Server for Biology
Quynh N VoChristopher R. Ellis
July 25, 2020
Open Access

A structural framework for unidirectional transport by a bacterial ABC exporter

Proceedings of the National Academy of Sciences of the United States of America
Chengcheng FanDouglas C Rees
August 14, 2020

Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction

Journal of the American Chemical Society
Dillon P CoganChaitan Khosla
August 23, 2020
Review
Open Access

How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs

International Journal of Molecular Sciences
Mariona Torrens-FontanalsJana Selent
August 5, 2020
Open Access

The Antibody Society's antibody validation webinar series

MAbs
Jan L A VoskuilSimon L Goodman
September 11, 2020
Review

Structural Biology of Human GPCR Drugs and Endogenous Ligands - Insights from NMR Spectroscopy

Methods : a Companion to Methods in Enzymology
Guillaume Ferré, Matthew Eddy
August 9, 2020
Review
Open Access

Mechanisms of Adhesion G protein Coupled Receptor Activation

The Journal of Biological Chemistry
Alexander VizurragaGregory G Tall
August 28, 2020

Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics

Journal of Computer-aided Molecular Design
Silvia AtanasioChristopher A Reynolds
July 31, 2020
Open Access

15-keto-PGE2 acts as a biased/partial agonist to terminate PGE2 -evoked signaling

The Journal of Biological Chemistry
Suzu EndoHiromichi Fujino
August 20, 2020
Open Access

GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Xinyi LiJian Wu
August 2, 2020

Benchmarking GPCR homology model template selection in combination with de novo loop generation

Journal of Computer-aided Molecular Design
Gregory L SzwabowskiAbby L Parrill
August 4, 2020
Open Access

Expression, purification and crystal structure determination of a ferredoxin reductase from the actinobacterium Thermobifida fusca

Acta Crystallographica. Section F, Structural Biology Communications
Jhon Alexander Rodriguez BuitragoAnett Schallmey
August 26, 2020
Open Access

Regulation of the thrombin/protease-activated receptor 1 axis by chemokine (C-X-C motif) receptor 4

The Journal of Biological Chemistry
Xianlong GaoMatthias Majetschak
September 8, 2020

Druggable Lysophospholipid Signaling Pathways

Advances in Experimental Medicine and Biology
Keisuke Yanagida, William J Valentine

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