Structure of GPCR

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research on structures of these receptors.

June 3, 2020

An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor

Nature Chemical Biology
Xiangyu LiuPeter Gmeiner
May 30, 2020
Open Access

A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin

Structure
Andreyah L PopeSteven O Smith
May 18, 2020
Open Access

Reproducibility: bypass animals for antibody production

Nature
Alison C GrayCarl A K Borrebaeck
May 8, 2020
Open Access

The post-synaptic scaffolding protein tamalin regulates ligand-mediated trafficking of metabotropic glutamate receptors

The Journal of Biological Chemistry
Saurabh PandeySamarjit Bhattacharyya
July 1, 2020

Production of perdeuterated fucose from glyco-engineered bacteria

Glycobiology
Lukas GajdosJuliette M Devos
May 2, 2020

Crystal and solution structures of fragments of the human leucocyte common antigen-related protein

Acta Crystallographica. Section D, Structural Biology
Joachim VilstrupSøren Thirup
June 5, 2020
Open Access

The nonselective cation channel TRPV4 inhibits angiotensin II receptors

The Journal of Biological Chemistry
Nicholas W ZaccorSolomon H Snyder
May 15, 2020

Coupling between plasmonic and photonic crystal modes in suspended three-dimensional meta-films

Optics Express
D Bruce BurckelMichael B Sinclair
April 28, 2020

Computational Insights into Molecular Activation and Positive Cooperative Mechanisms of FFAR1 Modulators

Journal of Chemical Information and Modeling
Dan TengGuixia Liu
May 10, 2020
Open Access

Site-specific epitope insertion into recombinant proteins using the MAP tag system

Journal of Biochemistry
Ayami WakasaTakao Arimori

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