Epigenetic modifications are carried out by proteins and protein complexes, many of which become dysregulated during diseases including cancer. Identifying structures of epigenetic machinery will shed light on proteins that govern various epigenetic processes and may aid in advancing therapeutics for certain diseases. Here is the latest research.
This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.
Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.
Beckwith-Wiedemann syndrome is an imprinting disorder characterized by overgrowth, congenital malformations and predisposition to tumors. Discover the latest research on Beckwith-Wiedemann Syndrome here.
Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.
Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.
The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.
Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.
Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.
DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.
Targeted epigenetic interventions provide the tools to prevent nociceptive sensitization, mood-related symptoms, and other adaptations that occur in response to injury or inflammation, which will facilitate pain management and improve treatment efficacy in many chronic pain conditions. Here is the latest research on the epigenetics changes in pain.