Structures of Epigenetic Machinery

Epigenetic modifications are carried out by proteins and protein complexes, many of which become dysregulated during diseases including cancer. Identifying structures of epigenetic machinery will shed light on proteins that govern various epigenetic processes and may aid in advancing therapeutics for certain diseases. Here is the latest research.

June 24, 2020

Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment

Nature Structural & Molecular Biology
Mélanie A Eckersley-MaslinWolf Reik
December 15, 2020
Open Access

Identification of lysine isobutyrylation as a new histone modification mark

Nucleic Acids Research
Zhesi ZhuY George Zheng
August 21, 2020

3D COMBO chrRNA-DNA-ImmunoFISH

Methods in Molecular Biology
Federica MarascaBeatrice Bodega
July 16, 2020
Review
Open Access

The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis

International Journal of Molecular Sciences
Nai-Yu KoKuo-Hu Chen
August 28, 2020
Review
Open Access

Interactions With Histone H3 & Tools to Study Them

Frontiers in Cell and Developmental Biology
William A Scott, Eric I Campos
October 21, 2020
Preprint
Open Access

Heterochromatin Replication: Direct Interaction of DNA replication machinery with heterochromatin code writer Clr4/Suv39 and reader Swi6/HP1 in S. pombe

BioRxiv : the Preprint Server for Biology
Jagmohan SinghS. Ahmed
November 27, 2020
Open Access

Rapid differentiation of human dental pulp stem cells to neuron-like cells by high K+ stimulation

Biophysics and Physicobiology
Yuki KogoEtsuro Ito
December 12, 2020

Selective Targeting of AF9 YEATS Domain by Cyclopeptide Inhibitors with Preorganized Conformation

Journal of the American Chemical Society
Yixiang JiangXiang David Li
September 2, 2020
Open Access

Benzyl Furanones and Pyrones from the Marine-Derived Fungus Aspergillus terreus Induced by Chemical Epigenetic Modification

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jing-Shuai WuChang-Yun Wang
December 17, 2020
Review

Regulation of processing bodies: From viruses to cancer epigenetic machinery

Cell Biology International
Sunmathy KanakamaniThejaswini Venkatesh
May 5, 2020

Interleukin-31 promotes pathogenic mechanisms underlying skin and lung fibrosis in scleroderma

Rheumatology
Bodoor YaseenRichard Stratton
August 21, 2020
Open Access

Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite

Molecular Systems Biology
Jessica M BryantArtur Scherf
May 7, 2020
Review
Open Access

The Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy

International Journal of Molecular Sciences
Magdalena Rudzińska, Barbara Czarnocka
April 22, 2020
Open Access

Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends

Nucleic Acids Research
Ramachandran BoopathiJan Bednar
January 2, 2021
Review

Therapeutic targets of cancer drugs: Modulation by melatonin

Life Sciences
Milad MoloudizargariRussel J Reiter
June 24, 2020

Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development

Nature Structural & Molecular Biology
Kristjan H Gretarsson, Jamie A Hackett
August 20, 2020

Role of DNA methylation on human CTSG in dermatomyositic myoideum

Cell Biology International
Yue PengYing Liang

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