Structures of Epigenetic Machinery

Epigenetic modifications are carried out by proteins and protein complexes, many of which become dysregulated during diseases including cancer. Identifying structures of epigenetic machinery will shed light on proteins that govern various epigenetic processes and may aid in advancing therapeutics for certain diseases. Here is the latest research.

June 24, 2020

Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment

Nature Structural & Molecular Biology
Mélanie A Eckersley-MaslinWolf Reik
July 16, 2020
Review
Open Access

The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis

International Journal of Molecular Sciences
Nai-Yu KoKuo-Hu Chen
November 14, 2019
Review

SAR by (Protein-Observed) 19 F NMR

Accounts of Chemical Research
Anand DivakaranWilliam C K Pomerantz
May 5, 2020

Interleukin-31 promotes pathogenic mechanisms underlying skin and lung fibrosis in scleroderma

Rheumatology
Bodoor YaseenRichard Stratton
November 13, 2019
Open Access

Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome

Structure
Yoshimasa TakizawaHitoshi Kurumizaka
May 7, 2020
Review
Open Access

The Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy

International Journal of Molecular Sciences
Magdalena Rudzińska, Barbara Czarnocka
April 2, 2020
Open Access

Generation of human oogonia from induced pluripotent stem cells in culture

Nature Protocols
Chika YamashiroMitinori Saitou
June 24, 2020

Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development

Nature Structural & Molecular Biology
Kristjan H Gretarsson, Jamie A Hackett
November 2, 2019
Open Access

Polycomb proteins as organizers of 3D genome architecture in embryonic stem cells

Briefings in Functional Genomics
Tomas PachanoAlvaro Rada-Iglesias
December 11, 2019
Review
Open Access

Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Renato Ferreira de FreitasMatthieu Schapira
June 9, 2020
Open Access

Linker histone epitopes are hidden by in situ higher-order chromatin structure

Epigenetics & Chromatin
Vladimir B TeifDonald E Olins
October 29, 2019
Open Access

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

ELife
Xiao-Chuan CaiMinkui Luo
June 27, 2020
Review
Open Access

Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy

Cancers
Flávia Alves VerzaMozart Marins
October 14, 2019
Open Access

Preparation of a new construct of human histone deacetylase 8 for the crystallization of enzyme-inhibitor complexes

Methods in Enzymology
Nicholas J Porter, David W Christianson
December 12, 2019
Review

From Loops to Looks: Transcription Factors and Chromatin Organization Shaping Terminal B Cell Differentiation

Trends in Immunology
Alba AzagraMaribel Parra
June 18, 2020

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues

Science Signaling
Kelan ChenJames M Murphy

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