Synapse Loss in Neurodegenerative Disorders

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at a much more rapid rate. A reduction in synaptic density has been observed in neurodegenerative disorders, including Multiple Sclerosis, providing a potential area to target for treatment. Here is the latest research on synapse loss in neurodegenerative disorders and as a potential therapeutic target.

December 4, 2021
Preprint
Open Access

Microglia Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntingtons Disease Through Complement-Dependent Mechanisms

BioRxiv : the Preprint Server for Biology
D. K. WiltonBeth stevens
December 1, 2021
Preprint
Open Access

Synapse-associated astrocyte mitochondria stabilize motor circuits to prevent excitotoxicity

BioRxiv : the Preprint Server for Biology
S. A. ZolnoskiSarah D Ackerman
November 26, 2021
Open Access

Controlling Alzheimer's Disease Through the Deep Brain Stimulation to Thalamic Relay Cells.

Frontiers in Computational Neuroscience
XiaoLi YangJürgen Kurths
November 26, 2021

Prion protein complexed to a DNA aptamer induce behavioral and synapse dysfunction in mice.

Behavioural Brain Research
Mariana P B GomesYraima Cordeiro
November 26, 2021
Review

Dysfunction of the blood-brain barrier in Alzheimer's disease: evidence from human studies.

Neuropathology and Applied Neurobiology
Carolin KurzRobert Perneczky
November 25, 2021
Preprint
Open Access

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimers disease

BioRxiv : the Preprint Server for Biology
J. YeapTara L Spires-Jones
November 24, 2021
Preprint
Open Access

Imaging synaptic microstructure and synaptic loss in vivo in early Alzheimers Disease

MedRxiv : the Preprint Server for Health Sciences
A. V. VenkataramanPaul M Matthews
November 23, 2021
Open Access

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis.

Frontiers in Neuroscience
Raquel Sanchez-VaroAntonia Gutierrez
November 15, 2021
Review
Open Access

Quality of Life and a Surveillant Endocannabinoid System.

Frontiers in Neuroscience
Ricardo Augusto de Melo ReisIsis Hara Trevenzoli
November 11, 2021
Preprint
Open Access

Neurons derived from individual early Alzheimer's disease patients reflect clinical vulnerability

BioRxiv : the Preprint Server for Biology
B. NgRichard Wade-Martins
November 11, 2021

Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration.

Neuroscience Bulletin
Chongyun WuRui Duan
November 11, 2021

Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.

Molecular Neurobiology
Tiziana PetrozzielloGhazaleh Sadri-Vakili
October 29, 2021
Open Access

The function of Scox in glial cells is essential for locomotive ability in Drosophila.

Scientific Reports
Ryosuke KowadaHideki Yoshida
October 27, 2021
Review

Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer's Disease.

Molecular Neurobiology
Manish Kumar, Nitin Bansal
October 22, 2021

Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis.

Neurobiology of Disease
Julien BourelThomas Tourdias
October 5, 2021
Preprint
Open Access

URMC-099 Prophylaxis Repairs Hippocampal Vascular Damage in an Orthopedic Model of Delirium Superimposed on Dementia

BioRxiv : the Preprint Server for Biology
P. Miller-RhodesH. A. Gelbard

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