Synthetic Lethality & Cancer Therapy

The genetic concept of synthetic lethality, in which the combination or synthesis of mutations in multiple genes results in cell death, provides a framework to design novel therapeutic approaches to cancer. Discover the latest research on synthetic lethality and cancer therapy here.

January 19, 2022

Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer.

Journal of Experimental & Clinical Cancer Research : CR
Zhang YangRen-Wang Peng
January 19, 2022
Open Access

Targeting of noncoding RNAs encoded by a novel MYC enhancers inhibits the proliferation of human hepatic carcinoma cells in vitro.

Scientific Reports
Hae In ChoiYoung Gyu Chai
January 19, 2022

Smart Strategies for Precise Delivery of CRISPR/Cas9 in Genome Editing.

ACS Applied Bio Materials
Akbar HasanzadehMichael R Hamblin
January 18, 2022
Preprint
Open Access

Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells

BioRxiv : the Preprint Server for Biology
L. Sanchez-BurgosOscar Fernandez-Capetillo
January 18, 2022
Preprint
Open Access

Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

BioRxiv : the Preprint Server for Biology
D. SherpaArno F Alpi
January 17, 2022

Veliparib for the treatment of solid malignancies.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Rony R GeorgeMeby S Mathew
January 17, 2022

Prostate cancer immunotherapy.

Expert Opinion on Biological Therapy
Iraklis MitsogiannisMohammad Moussa
January 17, 2022

Dual targeting, a new strategy for novel PARP inhibitor discovery.

Drug Discoveries & Therapeutics
Lina WeiZhiwu Han
January 17, 2022

Single-cell biology uncovers apoptotic cell death and its spatial organization as a potential modifier of tumor diversity in hepatocellular carcinoma.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Subreen A KhatibXin Wei Wang
January 17, 2022

Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.

Bioorganic & Medicinal Chemistry
Eman M E DoklaKhaled A M Abouzid
January 17, 2022
Review

Reflections on drug resistance to KRASG12C inhibitors and gene silencing/editing tools for targeting mutant KRAS in cancer treatment.

Biochimica Et Biophysica Acta. Reviews on Cancer
ZhaoYong HanXiYu Liu
January 17, 2022

Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis.

Journal of Experimental & Clinical Cancer Research : CR
Jingjing ZhangWeiwei Feng
January 16, 2022

Malignant pleural mesothelioma: Germline variants in DNA repair genes may steer tailored treatment.

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Marika SculcoIrma Dianzani
January 16, 2022

Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress.

Proceedings of the National Academy of Sciences of the United States of America
Yiji LiaoKexin Xu
January 15, 2022
Open Access

Clinical significance of metabolism-related genes and FAK activity in ovarian high-grade serous carcinoma.

BMC Cancer
Masakazu SatoKosei Hasegawa
January 15, 2022

Genome-wide screens identify specific drivers of mutant hTERT promoters.

Proceedings of the National Academy of Sciences of the United States of America
Raghuvaran ShanmugamVinay Tergaonkar

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