Synthetic Lethality & Cancer Therapy

The genetic concept of synthetic lethality, in which the combination or synthesis of mutations in multiple genes results in cell death, provides a framework to design novel therapeutic approaches to cancer. Discover the latest research on synthetic lethality and cancer therapy here.

July 12, 2020

Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency

Proceedings of the National Academy of Sciences of the United States of America
Lena J McLaughlinFeyruz V Rassool
July 1, 2020
Open Access

The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation

Human Reproduction
Amy L WinshipKarla J Hutt
July 10, 2020

Reactivation of Epstein-Barr Virus By HIF-1α Requires p53

Journal of Virology
Richard J KrausJanet E Mertz
July 3, 2020
Open Access

Efficacy and Prognostic Factors for PARP Inhibitors in Patients With Ovarian Cancer

Frontiers in Oncology
Xuan-Zhang HuangXin Zhou
July 1, 2020

Evolution of pathogenetic therapy of pulmonary arterial hypertension

Terapevticheskiĭ arkhiv
I E ChazovaN M Danilov
July 6, 2020

Poly adenosine diphosphate-ribosylation and neurodegenerative diseases

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Yi Wang, Yunbi Lu
July 12, 2020

Mainstreaming germline BRCA1/2 testing in non-mucinous epithelial ovarian cancer in the North West of England

European Journal of Human Genetics : EJHG
Nicola FlaumD Gareth R Evans
July 9, 2020
Comment / Editorial

DNA Repair and Prostate Cancer: A Field Ripe for Harvest

European Urology
Alan H BryceJohann de Bono
July 1, 2020
Open Access

Innovative Precision Gene-Editing Tools in Personalized Cancer Medicine

Advanced Science
Xiaofeng DaiKostya Ken Ostrikov
July 1, 2020

Systemic Therapy of Extensive Stage Small Cell Lung Cancer in the Era of Immunotherapy

Current Treatment Options in Oncology
Meera Ragavan, Millie Das
July 9, 2020
Open Access

Fluorescence-guided resection of tumors in mouse models of oral cancer

Scientific Reports
Paula Demétrio de Souza FrançaThomas Reiner
July 11, 2020

Efficacy and safety updates of poly ADP-ribose polymerase (PARP) inhibitor maintenance in ovarian cancer from ASCO 2020

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Ainhoa MadariagaStephanie Lheureux
June 26, 2020

Super-enhancer acquisition drives oncogene expression in triple negative breast cancer

PloS One
Ryan RaisnerKaren E Gascoigne

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