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Synucleinopathies

Synucleinopathies diagram by Designua, Shutterstock
Designua, Shutterstock

Synucleinopathies are neurodegenerative diseases characterized by accumulation of alpha-synuclein protein aggregates in neurons and glial cells. Discover the latest research on synucleinopathies here.

Top 20 most recent papers
Acta Neuropathologica

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Acta NeuropathologicaJanuary 20, 2020
Sven J van der LeeHenne Holstege
6
Autophagy

IFNB/interferon-β regulates autophagy via a MIR1 -TBC1D15-RAB7 pathway

AutophagyJanuary 21, 2020
Patrick EjlerskovRoger Pocock
3
bioRxiv

C subunit of the ATP synthase is an amyloidogenic channel-forming peptide: possible implications in mitochondrial pathogenesis

bioRxivJanuary 16, 2020
Giuseppe Federico AmodeoEvgeny V Pavlov
4
European Radiology

No effect of age, gender and total intracranial volume on brainstem MR planimetric measurements

European RadiologyJanuary 19, 2020
Stephanie MangesiusKlaus Seppi
bioRxiv

Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in alpha-synuclein-based mouse models of Parkinson's disease

bioRxivJanuary 13, 2020
Shi-Xun MaHan Seok Ko
4
The European Journal of Neuroscience

Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm

The European Journal of NeuroscienceJanuary 21, 2020
Ana Clara CristóvãoYoon-Seong Kim
1
Cell Reports

Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans

Cell ReportsJanuary 16, 2020
María Eugenia GoyaMaria Doitsidou
87
33
1
1
Annals of Clinical and Translational Neurology

CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration

Annals of Clinical and Translational NeurologyJanuary 21, 2020
Samir Abu-RumeilehMarkus Otto
Scientific Reports

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

Scientific ReportsJanuary 16, 2020
Matteo RunfolaGiuliana Fusco
5
1
Journal of Neurochemistry

Synucleinopathies: Where we are and where we need to go

Journal of NeurochemistryJanuary 21, 2020
Inês Caldeira BrásTiago Fleming Outeiro
10
Epilepsy & Behavior : E&B

Safety and tolerability of adjunctive brivaracetam in epilepsy: In-depth pooled analysis

Epilepsy & Behavior : E&BJanuary 16, 2020
Christian BrandtJohn Whitesides
3
ENeuro

Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses

ENeuroJanuary 17, 2020
Susan M L BanksJennifer R Morgan
11
ChemPlusChem

Stereochemistry, Stereodynamics, and Redox and Complexation Behaviors of 2,2'-Diaryl-1,1'-Biazulenes

ChemPlusChemJanuary 17, 2020
Takahiro TsuchiyaYasuhiro Mazaki
1
JAMA Neurology

Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial

JAMA NeurologyJanuary 14, 2020
Stephen MullinAnthony H V Schapira
80
2
2
Aging

Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson's disease

AgingJanuary 15, 2020
Adeline Su Lyn NgEng-King Tan
2
1
Chembiochem : a European Journal of Chemical Biology

Terminal Alkynes as Raman Probes of α-Synuclein in Solution and in Cells

Chembiochem : a European Journal of Chemical BiologyJanuary 22, 2020
Jessica D FlynnJennifer C Lee
Molecular Neurodegeneration

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Molecular NeurodegenerationJanuary 15, 2020
Jae-Hyeon ParkPamela J McLean
7
1
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Grouping Neuronal Spiking Patterns in the Subthalamic Nucleus of Parkinsonian Patients

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology SocietyJanuary 18, 2020
Heet KakuNuri F Ince
Neurotoxicity Research

p-Chloroamphetamine-Enhanced Neostriatal Dopamine Exocytosis in Rats Neonatally Co-lesioned with 6-OHDA and 5,7-DHT: Relevance to Parkinson's Disease

Neurotoxicity ResearchJanuary 16, 2020
John P Kostrzewa, Richard M Kostrzewa
1
Molecular Brain

Immunogold labeling of synaptic vesicle proteins in developing hippocampal neurons

Molecular BrainJanuary 22, 2020
Jung-Hwa Tao-Cheng

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