Systems Pharmacology of Proteinopathies

Systems pharmacology applies principles of systems biology to pharmacology to understand how drugs affect the human body. This feed focuses on systems pharmacology of proteinopathies- diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Here is the latest research.

May 16, 2020

Arsenic Exposure and Compromised Protein Quality Control

Chemical Research in Toxicology
Lok Ming Tam, Yinsheng Wang
May 9, 2020
Open Access

Transmission of ALS pathogenesis by the cerebrospinal fluid

Acta Neuropathologica Communications
Pooja Shree MishraJean-Pierre Julien
May 5, 2020
Open Access

TDP43 proteinopathy is associated with aberrant DNA methylation in human Amyotrophic Lateral Sclerosis

Neuropathology and Applied Neurobiology
Charlie Appleby-MallinderJ Robin Highley
May 22, 2020

DCTN1-related Parkinson-plus disorder (Perry syndrome)

Practical Neurology
Daniel RichardsonJeremy D Isaacs
July 4, 2020
Open Access

Quantitative patterns of motor cortex proteinopathy across ALS genotypes

Acta Neuropathologica Communications
Matthew NolanOlaf Ansorge
May 19, 2020

The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43

Neurobiology of Aging
Peiyan WongShuo-Chien Ling
August 3, 2020

Endosomal-lysosomal dysfunction in metabolic diseases and Alzheimer's disease

International Review of Neurobiology
Michael F AlmeidaStephen T Kinsey
July 28, 2020
Open Access

Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core

International Journal of Molecular Sciences
Elena VacchiGiorgia Melli
May 7, 2020
Open Access

Drosophila VCP/p97 Mediates Dynein-Dependent Retrograde Mitochondrial Motility in Axons

Frontiers in Cell and Developmental Biology
Ashley E Gonzalez, Xinnan Wang
June 26, 2020
Open Access

Therapeutic Approaches Targeting Protein Aggregation in Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience
Ravinder Malik, Martina Wiedau
July 1, 2020
Open Access

HspB5 Activates a Neuroprotective Glial Cell Response in Experimental Tauopathy

Frontiers in Neuroscience
David W HamptonSiddarthan Chandran
June 27, 2020
Comment / Editorial
Open Access

A New Gene for Susceptibility to Paget's Disease of Bone and for Multisystem Proteinopathy

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Stuart H Ralston
June 20, 2020

Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights

Critical Reviews in Eukaryotic Gene Expression
Keshav ThakurAkshay Anand
August 3, 2020

Neuropathological assessment of the Alzheimer spectrum

Journal of Neural Transmission
Kurt A Jellinger

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