T cell Education in the Thymus

T cell education in the thymus is critical for establishing a functional, yet self-tolerant, t cell repertoire. Here is the latest research.

September 10, 2020
Open Access

The Transcription Factor TCF1 in T Cell Differentiation and Aging.

International Journal of Molecular Sciences
Chulwoo KimJörg J Goronzy
January 6, 2021

A 2020 View of Thymus Stromal Cells in T Cell Development

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jianxun Han, Juan Carlos Zúñiga-Pflücker
September 2, 2020
Open Access

MicroRNA miR-181-A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function

International Journal of Molecular Sciences
Zoe Grewers, Andreas Krueger
July 30, 2020
Open Access

Loss of Mef2D function enhances TLR induced IL-10 production in macrophages

Bioscience Reports
Michael J PattisonJ Simon C Arthur
August 7, 2020
Open Access

Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development

The Journal of Cell Biology
Maile Romero-WolfHiroyuki Hosokawa
January 16, 2021

T Cell Development: Old Tales Retold By Single-Cell RNA Sequencing

Trends in Immunology
Chen LiuHongbo Hu
September 26, 2020
Open Access

Thymic Engraftment by in vitro -Derived Progenitor T Cells in Young and Aged Mice

Frontiers in Immunology
Jastaranpreet SinghJuan Carlos Zúñiga-Pflücker
January 10, 2021

Is the probable spillage of the lung surfactant dipalmitoylphosphatidylcholine the ultimate source of diabetes type 1?

Respiratory Physiology & Neurobiology
Ran ArieliOrna Dally Gottfried
November 29, 2020
Open Access

Retracing the evolutionary emergence of thymopoiesis

Science Advances
Jeremy B SwannThomas Boehm
November 17, 2020
Open Access

From thymus to periphery: Molecular basis of effector γδ-T cell differentiation

Immunological Reviews
Gina J FialaBruno Silva-Santos
December 4, 2020

mTORC2 negatively controls the maturation process of medullary thymic epithelial cells by inhibiting the LTβR/RANK-NF-κB axis

Journal of Cellular Physiology
Zhanfeng LiangYong Zhao
June 27, 2020
Open Access

The P2X7 Receptor as Regulator of T Cell Development and Function

Frontiers in Immunology
Fabio Grassi
July 28, 2020
Open Access

Liver X receptors are required for thymic resilience and T cell output

The Journal of Experimental Medicine
Christopher T ChanFilip K Swirski
January 13, 2021

RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus

Nature Immunology
Ana C F FerreiraAndrew N J McKenzie
September 13, 2020

How transcription factors drive choice of the T cell fate

Nature Reviews. Immunology
Hiroyuki Hosokawa, Ellen V Rothenberg
October 11, 2020
Open Access

Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export

International Immunology
Takahiro NagatakeYoko Hamazaki
September 17, 2020
Open Access

Functional definition of a transcription factor hierarchy regulating T cell lineage commitment

Science Advances
Laura Garcia-PerezFrank J T Staal
December 15, 2020
Open Access

Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds

Nature Communications
Sara CampinotiPaola Bonfanti

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