T Cell Reactivity to Tau & Alpha-Synuclein

Tau and alpha-synuclein are proteins that form aggregates which characterize various neurodegenerative disorders including Parkinson’s disease. This feed focuses on the T cell response to tau and alpha-synuclein.

February 18, 2021

LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo.

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Anke Van der PerrenEvy Lobbestael
February 14, 2021
Open Access

T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils.

Journal of Parkinson's Disease
Sonia GeorgePatrik Brundin
February 9, 2021
Review
Open Access

Periphery and brain, innate and adaptive immunity in Parkinson's disease.

Acta Neuropathologica
Ashley S HarmsMarina Romero-Ramos
February 3, 2021

Glial cells and adaptive immunity in frontotemporal dementia with tau pathology.

Brain : a Journal of Neurology
Iain J HartnellDelphine Boche
January 13, 2021
Open Access

The TCR repertoire of α-synuclein-specific T cells in Parkinson's disease is surprisingly diverse

Scientific Reports
Akul SinghaniaCecilia S Lindestam Arlehamn
January 10, 2021
Open Access

Sex- and age-dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice

Immunity & Ageing : I & a
Kelly B MeneesJae-Kyung Lee
January 5, 2021
Open Access

An Immune Gene-Related Five-lncRNA Signature for to Predict Glioma Prognosis

Frontiers in Genetics
Xinzhuang WangShiguang Zhao
December 5, 2020
Open Access

Neuroinflammation and protein pathology in Parkinson's disease dementia.

Acta Neuropathologica Communications
Antonina KouliCaroline H Williams-Gray
November 23, 2020
Open Access

Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease

Neurobiology of Disease
David J MarmionJeffrey H Kordower
October 30, 2020

CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease.

Brain : a Journal of Neurology
Jordi Galiano-LandeiraJordi Bové
October 16, 2020

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.

Science Translational Medicine
Changyoun KimEliezer Masliah
October 4, 2020
Review

Inflammation in Experimental Models of α-Synucleinopathies.

Movement Disorders : Official Journal of the Movement Disorder Society
Ashley S HarmsRobert H Mach
September 29, 2020
Open Access

T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls.

Frontiers in Neuroscience
Rekha DhanwaniCecilia S Lindestam Arlehamn
September 22, 2020
Open Access

Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion

Brain Communications
Alireza FaridarStanley H Appel
September 14, 2020

PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients

The Journal of Prevention of Alzheimer's Disease
H-Y WangL H Burns
September 10, 2020

Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein

Neuroscience Letters
Jorge A Trejo-LopezBenoit I Giasson

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