T cells: Costimulatory Receptors

T cell activation requires engagement of both the T cell receptor and a co-stimulatory molecule. Lack of a co-stimulatory signal can result in T cell anergy, deletion, or immune tolerance. Find the latest research on T cell co-stimulatory receptors here.

July 3, 2020
Review
Open Access

New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis

ESMO Open
Iñaki EtxeberriaIgnacio Melero
July 2, 2020
Open Access

CD8+ CD57+ T cells exhibit distinct features in human non-small cell lung cancer

Journal for Immunotherapy of Cancer
Bing HuangLequn Li
July 4, 2020

Therapeutic Monoclonal Antibodies in Clinical Practice against Cancer

Anti-cancer Agents in Medicinal Chemistry
Navgeet KaurRakesh K Sindhu
June 24, 2020
Review
Open Access

cGAS-STING, an important pathway in cancer immunotherapy

Journal of Hematology & Oncology
Minlin JiangCaicun Zhou
June 26, 2020

The therapeutic potential of targeting CD73 and CD73-derived adenosine in melanoma

Biochimie
Anvar SoleimaniMahmoud Reza Jaafari
July 6, 2020
Review

Immune checkpoint inhibitors: Key trials and an emerging role in breast cancer

Seminars in Cancer Biology
Nicola GaynorDenis M Collins
June 25, 2020

Blockade of CTLA-4 increases anti-tumor response inducing potential of dendritic cell vaccine

Journal of Controlled Release : Official Journal of the Controlled Release Society
Maryam EsmailyFarhad Jadidi-Niaragh
June 27, 2020
Open Access

Tumor Mutational Burden, Toxicity and Response of Immune Checkpoint Inhibitors (ICIs) Targeting PD(L)1, CTLA-4, and Combination: A Meta-Regression Analysis

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Arsen OsipovMark Yarchoan
June 25, 2020

Prognostic impacts of tumoral expression and serum levels of PD-L1 and CTLA-4 in colorectal cancer patients

Cancer Immunology, Immunotherapy : CII
Yusuke OmuraMasato Kusunoki
June 28, 2020

Soluble immune checkpoints CTLA-4, HLA-G, PD-1 and PD-L1 are associated with endometriosis-related infertility

American Journal of Reproductive Immunology : AJRI
Budi SantosoFadhil Ahsan

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