T cells: TNF and Death Receptors

Tumor necrosis factor alpha (TNFa) is an important signaling molecule throughout the immune system. Recent work has focused on the differences in expression and signaling pathways (inflammation vs. tissue regeneration) mediated by TNF receptor 1 (TNFR1) and TNFR2 and the potential for targeting one subtype over the other for therapeutic interventions. Find the latest research on T cells and TNF receptors here.

July 3, 2020
Review
Open Access

New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis

ESMO Open
Iñaki EtxeberriaIgnacio Melero
July 3, 2020
Review
Open Access

Immunomodulation of NK Cells by Ionizing Radiation

Frontiers in Oncology
Jiarui ChenConghua Xie
July 24, 2020

Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis

Journal of Cellular Physiology
You-Jin JoWoojin Jeong
August 19, 2020
Open Access

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

JCI Insight
Judith WienkeFemke van Wijk
August 28, 2020

Intracellular Galectin-3 Is Essential for OX40-Mediated Memory CD8+ T Cell Development

The Journal of Immunology : Official Journal of the American Association of Immunologists
Mohammad Farhad AmaniWilliam L Redmond
May 27, 2020
Open Access

HIV-Resistant and HIV-Specific CAR-Modified CD4+ T Cells Mitigate HIV Disease Progression and Confer CD4+ T Cell Help In Vivo

Molecular Therapy : the Journal of the American Society of Gene Therapy
Colby R MaldiniJames L Riley
May 26, 2020

TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models

Journal of Leukocyte Biology
Katherine CaseDenise L Faustman
July 27, 2020
Open Access

Bilateral Sensorineural Hearing Loss Associated With Nivolumab Therapy for Stage IV Malignant Melanoma

Ear, Nose, & Throat Journal
Alex J F TampioBrian D Nicholas
September 20, 2020
Review

Psoriasis and Antimicrobial Peptides

International Journal of Molecular Sciences
Toshiya Takahashi, Kenshi Yamasaki
June 7, 2020
Open Access

Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke

Acta Neuropathologica Communications
Bettina H ClausenKate L Lambertsen
May 29, 2020

CD8+ GITR+ T cells may negatively regulate T cell overactivation in aplastic anemia

Immunological Investigations
Guixuan HuangBo Li
September 8, 2020

Association between immunotherapy biomarkers and glucose metabolism from F-18 FDG PET

European Review for Medical and Pharmacological Sciences
B S KimY H Kim
May 27, 2020
Open Access

The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA

Disease Markers
Chengquan ShenYonghua Wang

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