T cells: TNF and Death Receptors

Tumor necrosis factor alpha (TNFa) is an important signaling molecule throughout the immune system. Recent work has focused on the differences in expression and signaling pathways (inflammation vs. tissue regeneration) mediated by TNF receptor 1 (TNFR1) and TNFR2 and the potential for targeting one subtype over the other for therapeutic interventions. Find the latest research on T cells and TNF receptors here.

January 7, 2020
Open Access

Next generation of anti-immune checkpoints antibodies

Médecine sciences : M/S
Nathalie BonnefoyBernard Vanhove
February 26, 2020

The future of cryoablation: An abscopal effect

Jibing ChenKecheng Xu
April 23, 2020

CD70 Activation Decreases Pulmonary Fibroblast Production of Extracellular Matrix Proteins

American Journal of Respiratory Cell and Molecular Biology
Thi K Tran-NguyenSteven R Duncan
May 14, 2020
Open Access

Structural optimization of a TNFR1-selective antagonistic TNF-α mutant to create new-modality TNF-regulating biologics

The Journal of Biological Chemistry
Masaki InoueShin-Ichi Tsunoda
January 8, 2020
Open Access

Co-Expression Profile of TNF Membrane-Bound Receptors Type 1 and 2 in Rheumatoid Arthritis on Immunocompetent Cells Subsets

International Journal of Molecular Sciences
Alina AlshevskayaSergey V Sennikov
February 21, 2020

Development and characterization of a novel anti-OX40 antibody for potent immune activation

Cancer Immunology, Immunotherapy : CII
Zhihui KuangJunjian Liu
May 26, 2020

TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models

Journal of Leukocyte Biology
Katherine CaseDenise L Faustman
December 19, 2019

T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity

Nature Immunology
Aakanksha JainChandrashekhar Pasare
March 24, 2020

Optimizing TNFR2 antagonism for immunotherapy with tumor microenvironment specificity

Journal of Leukocyte Biology
Michael YangDenise L Faustman
May 13, 2020

The expression of microRNAs and exposure to environmental contaminants related to human health: a review

International Journal of Environmental Health Research
Maria Rosaria TumoloSaverio Sabina
May 29, 2020

CD8+ GITR+ T cells may negatively regulate T cell overactivation in aplastic anemia

Immunological Investigations
Guixuan HuangBo Li
February 10, 2020
Open Access

Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients

Cancer Immunology, Immunotherapy : CII
Henna KasanenAnna Kreutzman
December 19, 2019
Open Access

Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases

Nature Communications
Simon MilettePnina Brodt

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