T cells: TNF and Death Receptors

Tumor necrosis factor alpha (TNFa) is an important signaling molecule throughout the immune system. Recent work has focused on the differences in expression and signaling pathways (inflammation vs. tissue regeneration) mediated by TNF receptor 1 (TNFR1) and TNFR2 and the potential for targeting one subtype over the other for therapeutic interventions. Find the latest research on T cells and TNF receptors here.

January 7, 2020
Open Access

Next generation of anti-immune checkpoints antibodies

Médecine sciences : M/S
Nathalie BonnefoyBernard Vanhove
February 26, 2020
Review

The future of cryoablation: An abscopal effect

Cryobiology
Jibing ChenKecheng Xu
April 23, 2020

CD70 Activation Decreases Pulmonary Fibroblast Production of Extracellular Matrix Proteins

American Journal of Respiratory Cell and Molecular Biology
Thi K Tran-NguyenSteven R Duncan
May 14, 2020
Open Access

Structural optimization of a TNFR1-selective antagonistic TNF-α mutant to create new-modality TNF-regulating biologics

The Journal of Biological Chemistry
Masaki InoueShin-Ichi Tsunoda
January 8, 2020
Open Access

Co-Expression Profile of TNF Membrane-Bound Receptors Type 1 and 2 in Rheumatoid Arthritis on Immunocompetent Cells Subsets

International Journal of Molecular Sciences
Alina AlshevskayaSergey V Sennikov
February 21, 2020

Development and characterization of a novel anti-OX40 antibody for potent immune activation

Cancer Immunology, Immunotherapy : CII
Zhihui KuangJunjian Liu
May 26, 2020

TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models

Journal of Leukocyte Biology
Katherine CaseDenise L Faustman
December 19, 2019

T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity

Nature Immunology
Aakanksha JainChandrashekhar Pasare
March 24, 2020

Optimizing TNFR2 antagonism for immunotherapy with tumor microenvironment specificity

Journal of Leukocyte Biology
Michael YangDenise L Faustman
May 13, 2020

The expression of microRNAs and exposure to environmental contaminants related to human health: a review

International Journal of Environmental Health Research
Maria Rosaria TumoloSaverio Sabina
May 29, 2020

CD8+ GITR+ T cells may negatively regulate T cell overactivation in aplastic anemia

Immunological Investigations
Guixuan HuangBo Li
February 10, 2020
Open Access

Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients

Cancer Immunology, Immunotherapy : CII
Henna KasanenAnna Kreutzman
December 19, 2019
Open Access

Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases

Nature Communications
Simon MilettePnina Brodt

Sign up to follow this feed and discover related papers.

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.


Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibody synthesis

Antibodies have various functions including neutralization of pathogens, tumor targeting, as well as its utility in biomedical research. Here is the latest research on antibody synthesis.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

© 2020 Meta ULC. All rights reserved
/feed-previews/t-cells-tnf-and-death-receptors/1f6784c5-aef3-4442-ae6e-971f91bc4f7a