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Target Site Alterations & Resistance

Target Site Alterations & Resistance diagram by Agudelo et al, PLOS One
Agudelo et al, PLOS One

Target site alteration is one of the mechanisms though which resistance to drugs can occur. For instance, amino acid substitutions can lead to an altered binding site for the drug which can lead to a decrease in the binding affinity of the drug to the target, thus conferring resistance to the drug. Here is the latest research on target site alterations and resistance.

Top 20 most recent papers
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

MET Alterations are a Recurring and Actionable Resistance Mechanism in ALK-Positive Lung Cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchFebruary 23, 2020
Ibiayi Dagogo-JackAaron N Hata
25
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

State-of-the-Art Strategies for Targeting RET -Dependent Cancers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical OncologyFebruary 22, 2020
Vivek SubbiahFunda Meric-Bernstam
33
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy

Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer ChemotherapyFebruary 23, 2020
Sabrina DallavalleRoberta Fruttero
Chemistry : a European Journal

Salinomycin Derivatives Kill Breast Cancer Stem Cells via Lysosomal Iron Targeting

Chemistry : a European JournalFebruary 22, 2020
Antoine VersiniRaphaël Rodriguez
Beilstein Journal of Organic Chemistry

Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo

Beilstein Journal of Organic ChemistryFebruary 22, 2020
Alexander SailerOliver Thorn-Seshold
2
Chemical Biology & Drug Design

Computational-based discovery of FAK FERM domain chemical probes that inhibit HER2-FAK cancer signaling

Chemical Biology & Drug DesignFebruary 22, 2020
Erik StahlTimothy Marlowe
Redox Biology

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone

Redox BiologyFebruary 3, 2020
Laura TorrenteGina M DeNicola
11
Molecular Therapy. Methods & Clinical Development

Point Mutations in Retargeted gD Eliminate the Sensitivity of EGFR/EGFRvIII-Targeted HSV to Key Neutralizing Antibodies

Molecular Therapy. Methods & Clinical DevelopmentFebruary 12, 2020
Ceren TuzmenJoseph C Glorioso
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Molecular mechanisms of acquired resistance to MET tyrosine kinase inhibitors in patients with MET exon 14 mutant NSCLC

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchFebruary 9, 2020
Gonzalo RecondoMark M Awad
98
1
Cancer Discovery

Advances in the Treatment of Acute Myeloid Leukemia: New Drugs and New Challenges

Cancer DiscoveryFebruary 5, 2020
Nicholas J ShortNaval Daver
44
International Journal of Molecular Sciences

Integrated Computational Approaches and Tools forAllosteric Drug Discovery

International Journal of Molecular SciencesFebruary 5, 2020
Olivier Sheik AmamuddyOzlem Tastan Bishop
4
Ticks and Tick-borne Diseases

Voltage-gated sodium channel gene mutations and pyrethroid resistance in Rhipicephalus microplus

Ticks and Tick-borne DiseasesFebruary 10, 2020
Rinesh KumarRobert J Miller
5

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