Target Site Alterations & Resistance

ABC Transporters or ATP-Binding Cassette Transporters are responsible for pumping out antibiotics in the cell and can lead to multidrug resistance in bacteria. Discover the latest research on ABC Transporters & Multidrug Resistance here.

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Drug inactivation or modification is one of the mechanisms through which resistance occurs. For instance, some penicillin-resistant bacteria produce beta-lactamases to enzymatically deactivate Penicillin G. Here is the latest research on drug inactivating enzymes and resistance.

Drug resistant infections are one of the biggest threats in our public health care system. Discover the latest research here.

Efflux-mediated drug resistance is one mechanism where bacteria can express proteins that pump out antibiotics, thereby rendering therapy ineffective. Discover the latest research on efflux-mediated drug resistance here.

Horizontal gene transfer is a mechanism in which genetic material is transmitted from one organism to another organism. This process is used by bacteria to acquire antibiotic resistance genes and is important for bacterial evolution. Discover the latest research on horizontal gene transfer here.

Infectious Disease Sequencing is a emerging field due to low-cost massively parallel sequencing and allows researchers to monitor outbreaks of infectious pathogens. Discover the latest research on Infectious Disease Sequencing here.

MRSA Infections or Methicillin-resistant Staphylococcus aureus infections are difficult to treat due to resistance to the beta-lactam family of antibiotics. MRSA infections are commonly acquired in hospitals. Discover the latest research on MRSA Infections here.

Metabolic pathways have been used as drug targets in the development of therapeutic compounds. Change of metabolic pathways can render the loss of therapeutic effects, a mechanism that is commonly found in drug resistance. Discover the latest research on metabolic pathways and drug resistance here.