Feed Preview

Target Site Alterations & Resistance

Target Site Alterations & Resistance diagram by Agudelo et al, PLOS One
Agudelo et al, PLOS One

Target site alteration is one of the mechanisms though which resistance to drugs can occur. For instance, amino acid substitutions can lead to an altered binding site for the drug which can lead to a decrease in the binding affinity of the drug to the target, thus conferring resistance to the drug. Here is the latest research on target site alterations and resistance.

Top 20 most recent papers
May 10, 2020
Review

Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges

Environmental Science and Pollution Research International
Dinesh KumarVeena Agrawal
May 6, 2020
ReviewOpen Access

Breaking through the glioblastoma micro-environment via extracellular vesicles

Oncogene
Thomas SimonGeorgios Giamas
May 14, 2020
Open Access

Insecticide resistance in Anopheles stephensi in Somali Region, eastern Ethiopia

Malaria Journal
Solomon YaredTamar E Carter
April 15, 2020

Enhanced metabolism and selection of pyrethroid-resistant western corn rootworms (Diabrotica virgifera virgifera LeConte)

Pesticide Biochemistry and Physiology
Dariane SouzaBlair D Siegfried
May 11, 2020
Review

Targeting Antimicrobial Drug Resistance with Marine Natural Products

International Journal of Antimicrobial Agents
Filipa BarbosaEmília Sousa
April 24, 2020

An Insight into the Current Perspective and Potential Drug Targets for Visceral Leishmania (VL)

Current Drug Targets
Rani Mansuri, Jagbir Singh
April 14, 2020
Review

CncC/Maf-mediated xenobiotic response pathway in insects

Archives of Insect Biochemistry and Physiology
Subba Reddy Palli
May 4, 2020

Investigation of resistance mechanism to fomesafen in Amaranthus retroflexus L

Pesticide Biochemistry and Physiology
Zhaofeng HuangShouhui Wei

See more papers from this feed

Related Feeds

ABC Transporters & Multidrug Resistance

ABC Transporters or ATP-Binding Cassette Transporters are responsible for pumping out antibiotics in the cell and can lead to multidrug resistance in bacteria. Discover the latest research on ABC Transporters & Multidrug Resistance here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Drug-Inactivating Enzymes & Resistance

Drug inactivation or modification is one of the mechanisms through which resistance occurs. For instance, some penicillin-resistant bacteria produce beta-lactamases to enzymatically deactivate Penicillin G. Here is the latest research on drug inactivating enzymes and resistance.

Drug-Resistant Infections

Drug resistant infections are one of the biggest threats in our public health care system. Discover the latest research here.

Efflux-Mediated Drug Resistance

Efflux-mediated drug resistance is one mechanism where bacteria can express proteins that pump out antibiotics, thereby rendering therapy ineffective. Discover the latest research on efflux-mediated drug resistance here.

Horizontal Gene Transfer

Horizontal gene transfer is a mechanism in which genetic material is transmitted from one organism to another organism. This process is used by bacteria to acquire antibiotic resistance genes and is important for bacterial evolution. Discover the latest research on horizontal gene transfer here.

Infectious Disease - Sequencing

Infectious Disease Sequencing is a emerging field due to low-cost massively parallel sequencing and allows researchers to monitor outbreaks of infectious pathogens. Discover the latest research on Infectious Disease Sequencing here.

MRSA Infections

MRSA Infections or Methicillin-resistant Staphylococcus aureus infections are difficult to treat due to resistance to the beta-lactam family of antibiotics. MRSA infections are commonly acquired in hospitals. Discover the latest research on MRSA Infections here.

Metabolic Pathways & Drug Resistance

Metabolic pathways have been used as drug targets in the development of therapeutic compounds. Change of metabolic pathways can render the loss of therapeutic effects, a mechanism that is commonly found in drug resistance. Discover the latest research on metabolic pathways and drug resistance here.

© 2020 Meta ULC. All rights reserved
/feed-previews/target-site-alterations-resistance/f96c54c2-dab4-4f32-9bf3-2b2b4f8d1058