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Target Site Alterations & Resistance
Agudelo et al, PLOS OneTarget site alteration is one of the mechanisms though which resistance to drugs can occur. For instance, amino acid substitutions can lead to an altered binding site for the drug which can lead to a decrease in the binding affinity of the drug to the target, thus conferring resistance to the drug. Here is the latest research on target site alterations and resistance.
Heterogeneous genetic invasions of three insecticide resistance mutations in Indo-Pacific populations of Aedes aegypti (L.)
Why orthoptera fauna resist of pesticide? First experimental data of resistance phenomena
Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges
Efflux Pumps Contribute to Intrinsic Clarithromycin Resistance in Clinical, Mycobacterium abscessus Isolates
Target-site EPSPS Pro-106-Ser mutation in Conyza canadensis biotypes with extreme resistance to glyphosate in Ohio and Iowa, USA
Breaking through the glioblastoma micro-environment via extracellular vesicles
Insecticide resistance in Anopheles stephensi in Somali Region, eastern Ethiopia
Development of a 3Mut-Apex-Stabilized Envelope Trimer that Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses
Enhanced metabolism and selection of pyrethroid-resistant western corn rootworms (Diabrotica virgifera virgifera LeConte)
Sulforaphane enhances the cisplatin sensitivity through regulating DNA repair and accumulation of intracellular cisplatin in ovarian cancer cells
Chloroplast dual divergent promoter plasmid for heterologous protein expression in Tetraselmis suecica (Chlorophyceae, Chlorodendrales)
Is Bismuth Really the "Green" Metal? Exploring the Antimicrobial Activity and Cytotoxicity of Organobismuth Thiolate Complexes
Targeting Antimicrobial Drug Resistance with Marine Natural Products
An Insight into the Current Perspective and Potential Drug Targets for Visceral Leishmania (VL)
Genotypic characterization of multiple drug resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt
CncC/Maf-mediated xenobiotic response pathway in insects
The First Case of Glyphosate Resistance in Johnsongrass (Sorghum halepense (L.) Pers.) in Europe
Investigation of resistance mechanism to fomesafen in Amaranthus retroflexus L
Phenotypic and molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae isolated in Tunisia
First Report of Biochemical Mechanisms of Insecticide Resistance in the Field Population of Culex pipiens (Diptera: Culicidae) from Sari, Mazandaran, North of Iran
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