Target Site Alterations & Resistance

Target site alteration is one of the mechanisms though which resistance to drugs can occur. For instance, amino acid substitutions can lead to an altered binding site for the drug which can lead to a decrease in the binding affinity of the drug to the target, thus conferring resistance to the drug. Here is the latest research on target site alterations and resistance.

January 18, 2021

Cytochrome P450 metabolism-based herbicide resistance to imazamox and 2,4-D in Papaver rhoeas

Plant Physiology and Biochemistry : PPB
Joel TorraRafael De Prado
October 4, 2020

Distribution of insecticide resistance and molecular mechanisms involved in the West Nile vector Culex pipiens in Morocco

Pest Management Science
Soukaina ArichM'Hammed Sarih
October 2, 2020
Open Access

enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9.

Molecular Therapy : the Journal of the American Society of Gene Therapy
Jasper Edgar NeggersDirk Daelemans
November 17, 2020
Open Access

Accumulation of Target Gene Mutations Confers Multiple Resistance to ALS, ACCase, and EPSPS Inhibitors in Lolium Species in Chile

Frontiers in Plant Science
José G Vazquez-GarciaRafael De Prado
December 15, 2020
Open Access

Detection of target-site and metabolic resistance to pyrethroids in the bed bug Cimex lectularius in Berlin, Germany

International Journal for Parasitology. Drugs and Drug Resistance
Arlette Vander PanJürgen Krücken
October 2, 2020
Review
Open Access

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Cancers
Qi-Yao WeiAndy T Y Lau
January 21, 2021

Multiple Herbicide Resistance Evolution: The Case of Eleusine indica in Brazil.

Journal of Agricultural and Food Chemistry
José G Vazquez-GarciaRafael De Prado
September 28, 2020

Resistance to pyridaben in Canadian greenhouse populations of two-spotted spider mites, Tetranychus urticae (Koch)

Pesticide Biochemistry and Physiology
Hooman Hosseinzadeh NaminIan M Scott
September 19, 2020

Molecular characterization of western corn rootworm pyrethroid resistance

Pest Management Science
Dariane SouzaNicholas J Miller
September 30, 2020

Diversity of α-tubulin transcripts in Lolium rigidum

Pest Management Science
Jinyi ChenStephen Powles
January 19, 2021
Review
Open Access

Advances in Fusarium Drug Resistance Research

Journal of Global Antimicrobial Resistance
Busi ZhaoLi Wang
December 8, 2020

Cross and multiple herbicide resistance in annual bluegrass (Poa annua) populations from eastern Texas golf courses

Pest Management Science
Vijay SinghMuthukumar Bagavathiannan

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