Feed Preview

Fast Growing

Targeted Gene Correction

Targeted Gene Correction diagram by Soleil Nordic, Shutterstock
Soleil Nordic, Shutterstock

Targeted gene repair is a technique that can be used to change the DNA sequence at a specific site in the genome to either correct or introduce a genetic mutation. Here is the latest research on targeted gene correction.

Top 20 most recent papers

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

bioRxivJanuary 7, 2020
Jeffrey R JohnsonNevan J Krogan

ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to PARP inhibition in lung cancer

bioRxivJanuary 10, 2020
Thaidy MorenoIgnacio Varela

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells

bioRxivJanuary 24, 2020
Paul van den BerkElisabetta Citterio

RECAS9: Recombining wild species introgression via mitotic gene editing in barley

bioRxivJanuary 8, 2020
Shelly LazarEyal Fridman
Current Opinion in Hematology

Driver mutations in acute myeloid leukemia

Current Opinion in HematologyJanuary 24, 2020
Ashwin KishtagariAaron D Viny
Molecular Therapy : the Journal of the American Society of Gene Therapy

Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9

Molecular Therapy : the Journal of the American Society of Gene TherapyJanuary 26, 2020
Jiahui WuColin J Chu

CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition

LeukemiaJanuary 25, 2020
Miguel Quijada-ÁlamoJesús María Hernández-Rivas
Nucleic Acids Research

Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing

Nucleic Acids ResearchJanuary 17, 2020
Jiaying YuLin Lin
DNA Repair

HPV induction of APOBEC3 enzymes mediate overall survival and response to cisplatin in head and neck cancer

DNA RepairJanuary 26, 2020
Kayla L ConnerSteve M Patrick
Acta Oncologica

Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis

Acta OncologicaJanuary 12, 2020
Luís NunesBengt Glimelius
Nature Communications

Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice

Nature CommunicationsJanuary 26, 2020
Koji M NishiguchiToru Nakazawa
Molecular Neurobiology

CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury

Molecular NeurobiologyJanuary 14, 2020
Vera PaschonAlexandre Hiroaki Kihara
DNA Repair

Single-stranded DNA damage: Protecting the single-stranded DNA from chemical attack

DNA RepairJanuary 26, 2020
Roy Anindya
Current Oncology Reports

Genetic Testing in Prostate Cancer

Current Oncology ReportsJanuary 25, 2020
Alexandra O Sokolova, Heather H Cheng

The genetics of intellectual disability: advancing technology and gene editing

F1000ResearchJanuary 28, 2020
Muhammad IlyasHenry Houlden
Hepatobiliary Surgery and Nutrition

Comprehensive molecular profiling of extrahepatic cholangiocarcinoma in Chinese population and potential targets for clinical practice

Hepatobiliary Surgery and NutritionJanuary 14, 2020
Liang XueWeiguang Gu

Development of Gene Editing Strategies for Human β-Globin (HBB) Gene Mutations

bioRxivJanuary 17, 2020
Batuhan M KalkanFatih Kocabas
Gynecologic Oncology

Therapeutic options for mucinous ovarian carcinoma

Gynecologic OncologyJanuary 7, 2020
Kylie L GorringeClare L Scott

Efficient replacement of long DNA fragments via non-homologous end joining at non-doding regions

bioRxivJanuary 14, 2020
Shan-Ye GuJiu-Lin Du
Current Opinion in Hematology

Tumor protein 53 mutations in acute myeloid leukemia: conventional induction chemotherapy or novel therapeutics

Current Opinion in HematologyJanuary 11, 2020
Hannah Asghari, Chetasi Talati

See more papers from this feed

Related Feeds

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Alzheimer's Disease: Genetics

Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.

Alzheimer's Disease: RNA Sequencing

RNA sequencing is used to reveal the presence and quantity of RNA in a given sample. In this feed, RNA sequencing investigates the genetic and molecular mechanisms related to the pathophysiology of Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA sequencing and this disease.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2020 Meta ULC. All rights reserved