Targeted Gene Correction

Targeted gene repair is a technique that can be used to change the DNA sequence at a specific site in the genome to either correct or introduce a genetic mutation. Here is the latest research on targeted gene correction.

July 14, 2020
Review

Progress and challenges towards CRISPR/Cas clinical translation

Advanced Drug Delivery Reviews
Daniel RosenblumDan Peer
July 23, 2020

Recent developments in enhancing the efficiency of CRISPR/Cas9- mediated knock-in in animals

Yi chuan = Hereditas
Guo Ling LiXian Wei Zhang
August 3, 2020

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer

DNA Repair
Maria BeecherBennett Van Houten
June 11, 2020

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

ELife
Joshua C CofskyJennifer A Doudna
July 11, 2020

Telomere replication-When the going gets tough

DNA Repair
Susanna Stroik, Eric A Hendrickson
July 9, 2020

Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome

Molecular Therapy. Methods & Clinical Development
Victoria GálvezFernando Larcher
July 16, 2020

Advances in Alpha-1 Antitrypsin Gene Therapy

American Journal of Respiratory Cell and Molecular Biology
Reka Lorincz, David T Curiel
June 23, 2020

CRISPR Genome Editing Technology and its Application in Genetic Diseases: A Review

Current Pharmaceutical Biotechnology
Sepideh KhatibiSeyed Hamid Aghaee Bakhtiari
July 23, 2020

Genomic and Clinical-Pathologic Characterization of ATM -deficient Prostate Cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Harsimar KaurTamara L Lotan
July 16, 2020
Preprint
Open Access

Cas9 fusions for precision in vivo editing

BioRxiv : the Preprint Server for Biology
R. R. RichardsonAlexandros Poulopoulos
July 28, 2020
Comment / Editorial

Telomeres come to life thanks to an exciting review article in this issue

DNA Repair
Samuel H Wilson
July 20, 2020

How to fix DNA-protein crosslinks

DNA Repair
Ulrike Kühbacher, Julien P Duxin
July 29, 2020

A programmable sequence of reporters for lineage analysis

Nature Neuroscience
Jorge Garcia-MarquesTzumin Lee
July 7, 2020
Preprint
Open Access

A High-efficacy CRISPRi System for Gene Function Discovery in Zymomonas mobilis

BioRxiv : the Preprint Server for Biology
Jason M PetersC. Siletti
July 29, 2020

AAV-BASED GENE THERAPY FOR LIFE-LONG CORRECTION OF GENETIC DISEASE

Human Gene Therapy
Christian BrommelPatrick L Sinn
July 28, 2020

Design and Evaluation of Guide RNA Transcripts with a 3'-Terminal HDV Ribozyme to Enhance CRISPR-Based Gene Inactivation

Methods in Molecular Biology
Ben BerkhoutElena Herrera-Carrillo

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