Targeted Gene Correction

Targeted gene repair is a technique that can be used to change the DNA sequence at a specific site in the genome to either correct or introduce a genetic mutation. Here is the latest research on targeted gene correction.

July 14, 2020

Progress and challenges towards CRISPR/Cas clinical translation

Advanced Drug Delivery Reviews
Daniel RosenblumDan Peer
July 23, 2020

Recent developments in enhancing the efficiency of CRISPR/Cas9- mediated knock-in in animals

Yi chuan = Hereditas
Guo Ling LiXian Wei Zhang
August 3, 2020

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer

DNA Repair
Maria BeecherBennett Van Houten
June 11, 2020

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

Joshua C CofskyJennifer A Doudna
July 11, 2020

Telomere replication-When the going gets tough

DNA Repair
Susanna Stroik, Eric A Hendrickson
July 9, 2020

Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome

Molecular Therapy. Methods & Clinical Development
Victoria GálvezFernando Larcher
July 16, 2020

Advances in Alpha-1 Antitrypsin Gene Therapy

American Journal of Respiratory Cell and Molecular Biology
Reka Lorincz, David T Curiel
June 23, 2020

CRISPR Genome Editing Technology and its Application in Genetic Diseases: A Review

Current Pharmaceutical Biotechnology
Sepideh KhatibiSeyed Hamid Aghaee Bakhtiari
July 23, 2020

Genomic and Clinical-Pathologic Characterization of ATM -deficient Prostate Cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Harsimar KaurTamara L Lotan
July 16, 2020
Open Access

Cas9 fusions for precision in vivo editing

BioRxiv : the Preprint Server for Biology
R. R. RichardsonAlexandros Poulopoulos
July 28, 2020
Comment / Editorial

Telomeres come to life thanks to an exciting review article in this issue

DNA Repair
Samuel H Wilson
July 20, 2020

How to fix DNA-protein crosslinks

DNA Repair
Ulrike Kühbacher, Julien P Duxin
July 29, 2020

A programmable sequence of reporters for lineage analysis

Nature Neuroscience
Jorge Garcia-MarquesTzumin Lee
July 7, 2020
Open Access

A High-efficacy CRISPRi System for Gene Function Discovery in Zymomonas mobilis

BioRxiv : the Preprint Server for Biology
Jason M PetersC. Siletti
July 29, 2020


Human Gene Therapy
Christian BrommelPatrick L Sinn
July 28, 2020

Design and Evaluation of Guide RNA Transcripts with a 3'-Terminal HDV Ribozyme to Enhance CRISPR-Based Gene Inactivation

Methods in Molecular Biology
Ben BerkhoutElena Herrera-Carrillo

Sign up to follow this feed and discover related papers.

Related Feeds

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Alzheimer's Disease: Genetics

Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.

Alzheimer's Disease: RNA Sequencing

RNA sequencing is used to reveal the presence and quantity of RNA in a given sample. In this feed, RNA sequencing investigates the genetic and molecular mechanisms related to the pathophysiology of Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA sequencing and this disease.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2020 Meta ULC. All rights reserved