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Targeted Gene Correction

Targeted Gene Correction diagram by Soleil Nordic, Shutterstock
Soleil Nordic, Shutterstock

Targeted gene repair is a technique that can be used to change the DNA sequence at a specific site in the genome to either correct or introduce a genetic mutation. Here is the latest research on targeted gene correction.

Top 20 most recent papers
bioRxiv

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

bioRxivJanuary 7, 2020
Jeffrey R JohnsonNevan J Krogan
6
bioRxiv

ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to PARP inhibition in lung cancer

bioRxivJanuary 10, 2020
Thaidy MorenoIgnacio Varela
4
bioRxiv

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells

bioRxivJanuary 24, 2020
Paul van den BerkElisabetta Citterio
bioRxiv

RECAS9: Recombining wild species introgression via mitotic gene editing in barley

bioRxivJanuary 8, 2020
Shelly LazarEyal Fridman
10
Current Opinion in Hematology

Driver mutations in acute myeloid leukemia

Current Opinion in HematologyJanuary 24, 2020
Ashwin KishtagariAaron D Viny
15
Molecular Therapy : the Journal of the American Society of Gene Therapy

Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9

Molecular Therapy : the Journal of the American Society of Gene TherapyJanuary 26, 2020
Jiahui WuColin J Chu
3
Leukemia

CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition

LeukemiaJanuary 25, 2020
Miguel Quijada-ÁlamoJesús María Hernández-Rivas
2
Nucleic Acids Research

Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing

Nucleic Acids ResearchJanuary 17, 2020
Jiaying YuLin Lin
4
DNA Repair

HPV induction of APOBEC3 enzymes mediate overall survival and response to cisplatin in head and neck cancer

DNA RepairJanuary 26, 2020
Kayla L ConnerSteve M Patrick
Acta Oncologica

Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis

Acta OncologicaJanuary 12, 2020
Luís NunesBengt Glimelius
1
Nature Communications

Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice

Nature CommunicationsJanuary 26, 2020
Koji M NishiguchiToru Nakazawa
2
Molecular Neurobiology

CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury

Molecular NeurobiologyJanuary 14, 2020
Vera PaschonAlexandre Hiroaki Kihara
1
DNA Repair

Single-stranded DNA damage: Protecting the single-stranded DNA from chemical attack

DNA RepairJanuary 26, 2020
Roy Anindya
Current Oncology Reports

Genetic Testing in Prostate Cancer

Current Oncology ReportsJanuary 25, 2020
Alexandra O Sokolova, Heather H Cheng
F1000Research

The genetics of intellectual disability: advancing technology and gene editing

F1000ResearchJanuary 28, 2020
Muhammad IlyasHenry Houlden
Hepatobiliary Surgery and Nutrition

Comprehensive molecular profiling of extrahepatic cholangiocarcinoma in Chinese population and potential targets for clinical practice

Hepatobiliary Surgery and NutritionJanuary 14, 2020
Liang XueWeiguang Gu
1
bioRxiv

Development of Gene Editing Strategies for Human β-Globin (HBB) Gene Mutations

bioRxivJanuary 17, 2020
Batuhan M KalkanFatih Kocabas
2
Gynecologic Oncology

Therapeutic options for mucinous ovarian carcinoma

Gynecologic OncologyJanuary 7, 2020
Kylie L GorringeClare L Scott
23
bioRxiv

Efficient replacement of long DNA fragments via non-homologous end joining at non-doding regions

bioRxivJanuary 14, 2020
Shan-Ye GuJiu-Lin Du
7
Current Opinion in Hematology

Tumor protein 53 mutations in acute myeloid leukemia: conventional induction chemotherapy or novel therapeutics

Current Opinion in HematologyJanuary 11, 2020
Hannah Asghari, Chetasi Talati
1

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