Tau & Neurodegeneration

Tau proteins include six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau). Combating tau-associated pathologies is a key focus of neurodegeneration research. Here is the latest research on tau and neurodegeneration.

November 15, 2020
Open Access

Molecular estimation of neurodegeneration pseudotime in older brains

Nature Communications
Sumit MukherjeeBenjamin A Logsdon
November 19, 2020

Progressive supranuclear palsy: Neuropathology of patients with a short disease duration due to unexpected death

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Lu ZhangAkiyoshi Kakita
November 17, 2020
Open Access

TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer's Disease

Frontiers in Cell and Developmental Biology
Jian MengYun-Wu Zhang
November 24, 2020

ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Katheryn A Q CousinsMurray Grossman
October 29, 2020

Socioeconomic Status Mediates Racial Differences Seen Using the AT(N) Framework

Annals of Neurology
Karin L MeekerBeau M Ances
November 3, 2020

The AT(N) framework for Alzheimer's disease in adults with Down syndrome

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Michael S RafiiSid O'Bryant
October 27, 2020
Open Access

Neuroprotective Effects of OMO within the Hippocampus and Cortex in a D-Galactose and Aβ25-35 -Induced Rat Model of Alzheimer's Disease

Evidence-based Complementary and Alternative Medicine : ECAM
Shaodong DengHaiyi Ye
November 5, 2020

Clinicopathological investigation of the background of cognitive decline in elderly schizophrenia

Acta Neuropsychiatrica
Ayako MiwaShuji Iritani
November 15, 2020
Review
Open Access

Fluid Candidate Biomarkers for Alzheimer's Disease: A Precision Medicine Approach

Journal of Personalized Medicine
Eleonora Del PreteFilippo Baldacci
November 1, 2020
Open Access

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes

Molecular Therapy : the Journal of the American Society of Gene Therapy
Marshall S GoodwinYona Levites
November 11, 2020

Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer´s cerebral pathology and clinical disease progression

The Journal of Steroid Biochemistry and Molecular Biology
Tabea JahnJulius Popp
November 17, 2020
Open Access

Connecting Alzheimer's Disease With Diabetes Mellitus Through Amyloidogenic Evolvability

Frontiers in Aging Neuroscience
Gilbert HoMakoto Hashimoto
November 17, 2020

Differential DNA methylation of the genes for amyloid precursor protein, tau and neurofilaments in human traumatic brain injury

Journal of Neurotrauma
Sami Abu HamdehNiklas Marklund
November 21, 2020

Cognitive Performance and Cerebrospinal Fluid Markers in Preclinical Alzheimer's Disease: Results from the Gothenburg H70 Birth Cohort Studies

Journal of Alzheimer's Disease : JAD
Maya Arvidsson RådestigSilke Kern
November 19, 2020
Open Access

Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

Cell Reports
Jessica E RexachDaniel H Geschwind
November 11, 2020
Open Access

Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model

Molecular Neurodegeneration
Sanjib GuhaKeith Nehrke
October 27, 2020
Open Access

Cerebrospinal Fluid Metals and the Association with Cerebral Small Vessel Disease

Journal of Alzheimer's Disease : JAD
Mana ShamsSara Shams

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