Tauopathies: Structural Basis of Protein Pathology

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. This feed focuses on the structural basis of protein pathology in tauopathies. Here is the latest research.

June 24, 2020

MiR-199a modulates autophagy and inflammation in rats with cerebral infarction via regulating mTOR expression

European Review for Medical and Pharmacological Sciences
J ZhouH Wu
July 23, 2020

Interactions of IDPs with Membranes Using Dark-State Exchange NMR Spectroscopy

Methods in Molecular Biology
Tapojyoti DasDavid Eliezer
June 6, 2020
Open Access

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

Nature Communications
Nicholas M KanaanBenjamin Combs
May 12, 2020
Open Access

Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease

Brain : a Journal of Neurology
John D ArenaVictoria E Johnson
June 2, 2020

Emerging Proof of Protein Misfolding and Interaction in Multifactorial Alzheimer's Disease

Current Topics in Medicinal Chemistry
Md Sahab UddinGhulam Md Ashraf
June 6, 2020
Preprint
Open Access

Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy

BioRxiv : the Preprint Server for Biology
C. FungKaren Duff
May 6, 2020
Review
Open Access

Shared Genomic and Proteomic Contribution of Amyloid and Tau Protein Characteristic of Alzheimer's Disease to Brain Ischemia

International Journal of Molecular Sciences
Ryszard PlutaStanisław J Czuczwar
August 3, 2020

The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases

International Review of Neurobiology
Molly Braun, Jeffrey J Iliff
June 25, 2020
Review
Open Access

Heart and Brain: Complex Relationships for Left Ventricular Dysfunction

Current Cardiology Reports
Gianlorenzo DanieleFederica Del Monte
April 30, 2020
Open Access

Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Somin KwonEliezer Masliah
April 16, 2020
Open Access

Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases

Brain Pathology
Tomoko MikiNorihito Yamada
July 18, 2020

Viral Delivery of Non-Mutated Human Truncated Tau to Neurons Recapitulates Key Features of Human Tauopathy in Wild-Type Mice

Journal of Alzheimer's Disease : JAD
Thomas VogelsTomáš Hromádka
July 6, 2020

Structures of the intrinsically disordered Aβ, tau and α-synuclein proteins in aqueous solution from computer simulations

Biophysical Chemistry
Phuong H Nguyen, Philippe Derreumaux
July 28, 2020

Challenges in Alzheimer's Disease Diagnostic Work-Up: Amyloid Biomarker Incongruences

Journal of Alzheimer's Disease : JAD
Gemma LombardiSandro Sorbi
June 5, 2020
Open Access

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

Quarterly Reviews of Biophysics
Tessa SinnigeMichele Vendruscolo
July 23, 2020

Probing IDP Interactions with Membranes by Fluorescence Spectroscopy

Methods in Molecular Biology
Diana AcostaDavid Eliezer

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