Tauopathies: Structural Basis of Protein Pathology

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. This feed focuses on the structural basis of protein pathology in tauopathies. Here is the latest research.

November 13, 2020
Preprint
Open Access

Exome Sequencing Revealed PDE11A as a Novel Candidate Gene for Early-Onset Alzheimer's disease

ResearchSquare
Wei QinJianping Jia
October 20, 2020
Review
Open Access

Astrocytes in Tauopathies

Frontiers in Neurology
Matthew J ReidWendy Noble
November 13, 2020
Review
Open Access

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

Frontiers in Neurology
Usman SaeedMario Masellis
October 7, 2020
Preprint
Open Access

Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease

BioRxiv : the Preprint Server for Biology
H. HayturalGael Barthet
January 4, 2021
Preprint
Open Access

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

ResearchSquare
Lukasz JoachimiakOmar Kashmer
January 13, 2021
Open Access

Molecular characterization of selectively vulnerable neurons in Alzheimer's disease

Nature Neuroscience
Kun LengMartin Kampmann
January 9, 2021
Preprint
Open Access

Decoupling of global brain activity and cerebrospinal fluid flow in Parkinson's cognitive decline

BioRxiv : the Preprint Server for Biology
F. HanXiao Liu
October 20, 2020
Review
Open Access

The Role of Copper in Tau-Related Pathology in Alzheimer's Disease

Frontiers in Molecular Neuroscience
Klara ZubčićMaja Jazvinšćak Jembrek
January 18, 2021

Inflammation and Parkinson's disease pathogenesis: Mechanisms and therapeutic insight

Progress in Molecular Biology and Translational Science
Gianluigi ForloniClaudia Balducci
November 2, 2020

α-Linolenic acid inhibits Tau aggregation and modulates Tau conformation

International Journal of Biological Macromolecules
Smita Eknath DesaleSubashchandrabose Chinnathambi
October 9, 2020
Preprint
Open Access

Catechol-Containing Compounds are a Broad Class of Amyloid Inhibitors: Redox State is a Key Determinant of the Inhibitory Activities

BioRxiv : the Preprint Server for Biology
P. VelanderBin Xu
December 31, 2020
Open Access

A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages

Journal of Personalized Medicine
Giulia AbateDaniela Uberti
November 10, 2020
Preprint
Open Access

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

BioRxiv : the Preprint Server for Biology
Z. F. BrotzakisMichele Vendruscolo
October 27, 2020
Open Access

Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins

Frontiers in Neurology
Lulu JiangBenjamin Wolozin
December 31, 2020

Understanding the Structure and Apo Dynamics of the Functionally Active JIP1 Fragment

Journal of Chemical Information and Modeling
Neda OjaghlouCarol A Parish
January 8, 2021
Review
Open Access

Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies

Chinese Medicine
Abdullahi AlausaAminat Ismail
October 29, 2020
Open Access

Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs

Scientific Reports
Meenakshisundaram BalasubramaniamRobert J Shmookler Reis

Sign up to follow this feed and discover related papers.

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

ALS & FTD: TDP-43

TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

© 2021 Meta ULC. All rights reserved
/feed-previews/tauopathies-structural-basis-of-protein/0606fdb8-76a2-4d13-b97a-de2853b3b855