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TDP-43 Proteinopathies

TDP-43 Proteinopathies diagram by Emw, Wikimedia
Emw, Wikimedia

TAR DNA binding protein (TDP43) is a DNA and RNA binding protein that is implicated in several neurodegenerative disorders known as “TDP43 proteinopathies" including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. Here is the latest research.

Top 20 most recent papers
Brain : a Journal of Neurology

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum

Brain : a Journal of NeurologyMarch 18, 2020
W Richard Bevan-JonesJames B Rowe
72
27
Neuropathology and Applied Neurobiology

Brain mural cell loss in the parietal cortex in alzheimer's disease correlates with cognitive decline and TDP-43 pathology

Neuropathology and Applied NeurobiologyJanuary 24, 2020
Philippe BourassaFrédéric Calon
10
1
bioRxiv

Phe-Gly Motifs Drive Fibrillization of TDP-43's Prion-Like Domain Droplets

bioRxivFebruary 21, 2020
David Pantoja-UcedaMiguel Mompean
16
Brain : a Journal of Neurology

CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis

Brain : a Journal of NeurologyMarch 19, 2020
Carol Dobson-StoneJohn B Kwok
62
Revue neurologique

Cognitive deficit, and neuropathological correlates, in the oldest-old

Revue neurologiqueMarch 18, 2020
M Verny, C Duyckaerts
1
293
10
1
35
Brain : a Journal of Neurology

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis

Brain : a Journal of NeurologyFebruary 11, 2020
Phillip SmethurstRickie Patani
49
8
3
1
Frontiers in Molecular Neuroscience

TDP-43: From Alzheimer's Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy

Frontiers in Molecular NeuroscienceMarch 18, 2020
Wendi HuangYong Luo
4
1
Frontiers in Molecular Neuroscience

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation

Frontiers in Molecular NeuroscienceMarch 6, 2020
Fernando OrmeñoMauricio Budini
3
1
Acta Neuropathologica Communications

A robust TDP-43 knock-in mouse model of ALS

Acta Neuropathologica CommunicationsJanuary 23, 2020
Shih-Ling HuangChe-Kun James Shen
5
1
NeuroImage. Clinical

Basal forebrain atrophy in frontotemporal dementia

NeuroImage. ClinicalMarch 7, 2020
Rhian S ConveryMartina Bocchetta
2
1

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