TDP-43 Proteinopathies

TAR DNA binding protein (TDP43) is a DNA and RNA binding protein that is implicated in several neurodegenerative disorders known as “TDP43 proteinopathies" including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. Here is the latest research.

July 28, 2020
Preprint
Open Access

Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1

BioRxiv : the Preprint Server for Biology
E. PokrishevskyN. R. Cashman
September 1, 2020

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

Nature
Jiasheng ZhangEric J Huang
August 25, 2020

Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo

Journal of Neuropathology and Experimental Neurology
Sarah A WeitzmanVirginia M Y Lee
September 10, 2020

Novel Monoclonal Antibodies Targeting the RRM2 domain of Human TDP-43 Protein

Neuroscience Letters
Jorge A Trejo-LopezBenoit I Giasson
August 14, 2020
Open Access

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia

The Journal of Clinical Investigation
Mercedes PrudencioLeonard Petrucelli
August 23, 2020
Open Access

Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons

Neurobiology of Disease
Antonia RattiClaudia Colombrita
September 13, 2020

Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Yuemang YaoKurt R Brunden
August 18, 2020
Open Access

Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology

NeuroImage. Clinical
V BorghesaniM L Gorno-Tempini
August 5, 2020
Open Access

Defining and predicting transdiagnostic categories of neurodegenerative disease

Nature Biomedical Engineering
Eli J CornblathDanielle S Bassett
August 18, 2020
Review
Open Access

The role of TDP-43 mislocalization in amyotrophic lateral sclerosis

Molecular Neurodegeneration
Terry R Suk, Maxime W C Rousseaux
August 18, 2020

TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons

Acta Neuropathologica
Seiichi NaganoToshiyuki Araki
September 3, 2020
Preprint
Open Access

BrainPhys neuronal medium optimized for imaging and optogenetics in vitro

BioRxiv : the Preprint Server for Biology
M. ZabolockiCedric Bardy
September 18, 2020
Review

Amyotrophic lateral sclerosis and lead: A systematic update

Neurotoxicology
Cristiano FaraceRoberto Madeddu
August 17, 2020
Open Access

Non-EPI-DWI for Detection, Disease Monitoring, and Clinical Decision-Making in Thyroid Eye Disease

AJNR. American Journal of Neuroradiology
C FeeneyS Nagendran
September 15, 2020
Review
Open Access

Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo

Neurobiology of Disease
Charlton G OtteChristopher J Donnelly
August 9, 2020
Comment / Editorial

TDP-43 Nuclear Bodies: A NEAT Response to Stress?

Molecular Cell
Ahmed M Malik, Sami J Barmada
July 28, 2020

Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Mitchel A KlingAlzheimer's Disease Metabolomics Consortium (ADMC) and the Alzheimer's Disease Neuroimaging Initiative (ADNI)
September 4, 2020
Open Access

C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy

Science Translational Medicine
Casey N CookLeonard Petrucelli
August 21, 2020
Open Access

Combination of acamprosate and baclofen (PXT864) as a potential new therapy for amyotrophic lateral sclerosis

Journal of Neuroscience Research
Lydie BoussicaultDaniel Cohen

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