TDP-43 Proteinopathies

TAR DNA binding protein (TDP43) is a DNA and RNA binding protein that is implicated in several neurodegenerative disorders known as “TDP43 proteinopathies" including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. Here is the latest research.

September 15, 2021
Open Access

A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin.

Scientific Reports
Phaneendra ChennampallyRosemary L Smith
September 10, 2021
Open Access

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice.

Acta Neuropathologica Communications
Argyro Thalia DelizannisKurt R Brunden
September 9, 2021

Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress.

Cell Reports
Sebastian MarkmillerGene W Yeo
September 8, 2021
Preprint
Open Access

Susceptibility to postmortem (co)-pathologies in antemortem atrophy-based subtypes of Alzheimer's disease

MedRxiv : the Preprint Server for Health Sciences
Rosaleena MohantyE. Westman
September 7, 2021
Review

Elucidating the Role of Cerebellar Synaptic Dysfunction in C9orf72-ALS/FTD - a Systematic Review and Meta-Analysis.

The Cerebellum
Aleksandra KaliszewskaNatalia Arias
September 7, 2021
Open Access

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation.

ELife
Juan Carlos Rengifo-GonzalezAhmed Bouhss
September 7, 2021

Creating doorways: finding meaning and growth through art therapy in the face of life-threatening illness.

Public Health
R C ReillyA Robitaille
September 6, 2021

NEAT1 lncRNA and amyotrophic lateral sclerosis.

Neurochemistry International
Yoshinori NishimotoHideyuki Okano
September 4, 2021

Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease.

Movement Disorders : Official Journal of the Movement Disorder Society
Whitley W AamodtAlice S Chen-Plotkin
September 3, 2021

Neuropathologic Findings in a Patient With Juvenile-Onset Levodopa Responsive Parkinsonism Due to ATP13A2 Mutation.

Neurology
Hsin Fen ChienEgberto Reis Barbosa
September 2, 2021
Open Access

ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.

Communications Biology
Maria Giovanna GaroneAlessandro Rosa
September 2, 2021
Review

Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?

The FEBS Journal
Hannelore HartmannShuo-Chien Ling
September 2, 2021

Aptamer-based enrichment of TDP-43 from human cells and tissues with quantification by HPLC-MS/MS.

Journal of Neuroscience Methods
Taylor D PobranMari L DeMarco
September 1, 2021
Review

Nuclear-import receptors counter deleterious phase transitions in neurodegenerative disease.

Journal of Molecular Biology
Hana M OdehJames Shorter
August 30, 2021
Review
Open Access

Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape.

RSC Chemical Biology
Liberty Francois-MoutalMay Khanna
August 30, 2021
Open Access

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.

Acta Neuropathologica Communications
Ethan W HassBenoit I Giasson
August 28, 2021
Open Access

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils.

Viruses
Carlo ScialòGiuseppe Legname

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