Feed Preview

Fast Growing

TDP-43 Proteinopathies

TDP-43 Proteinopathies diagram by Emw, Wikimedia
Emw, Wikimedia

TAR DNA binding protein (TDP43) is a DNA and RNA binding protein that is implicated in several neurodegenerative disorders known as “TDP43 proteinopathies" including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. Here is the latest research.

Top 20 most recent papers
bioRxiv

Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP-43-C pathology

bioRxivNovember 20, 2019
Valentina BorghesaniMaria Luisa Gorno-Tempini
2
bioRxiv

TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression

bioRxivDecember 13, 2019
Josiah J. HerzogSuzanne Paradis
2
Scientific Reports

SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1

Scientific ReportsDecember 12, 2019
Rebecca CacciottoloRuben J Cauchi
5
3
1
Neuropathology and Applied Neurobiology

Brain mural cell loss in the parietal cortex in alzheimer's disease correlates with cognitive decline and TDP-43 pathology

Neuropathology and Applied NeurobiologyJanuary 24, 2020
Philippe BourassaFrédéric Calon
Brain : a Journal of Neurology

Homozygous GRN mutations: new phenotypes and new insights into pathological and molecular mechanisms

Brain : a Journal of NeurologyDecember 20, 2019
Vincent HuinIsabelle Le Ber
15
1
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration

The first case of the TARDBP p.G294V mutation in a homozygous state: is a single pathogenic allele sufficient to cause ALS?

Amyotrophic Lateral Sclerosis & Frontotemporal DegenerationDecember 20, 2019
Lucia CorradoSandra D'Alfonso
Revue médicale suisse

Neurology 2019

Revue médicale suisseJanuary 22, 2020
Matthieu PerrenoudRenaud Du Pasquier
1
Journal of Alzheimer's Disease : JAD

Effect Modifiers of TDP-43 Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes

Journal of Alzheimer's Disease : JADJanuary 14, 2020
Marina BuciucKeith A Josephs
1
International Journal of Molecular Sciences

Inter-Species Differences in Regulation of the Progranulin-Sortilin Axis in TDP-43 Cell Models of Neurodegeneration

International Journal of Molecular SciencesNovember 27, 2019
Valentina GuminaAntonia Ratti
2
1
bioRxiv

FUS gene is dual-coding with both proteins united in molecular hallmarks of amyotrophic lateral sclerosis

bioRxivNovember 20, 2019
Marie A BrunetXavier Roucou
30
6
International Journal of Biological Macromolecules

Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C -A315T by AIM4

International Journal of Biological MacromoleculesJanuary 10, 2020
Amandeep GirdharBasant K Patel
1
Acta Neuropathologica Communications

Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases

Acta Neuropathologica CommunicationsDecember 4, 2019
Lieselot DedeeneDietmar Rudolf Thal
2
2
JAMA Neurology

Survival and Prognostic Factors in C9orf72 Repeat Expansion Carriers: A Systematic Review and Meta-analysis

JAMA NeurologyNovember 19, 2019
Stella A GlasmacherSuvankar Pal
17
1
Revue neurologique

Pre-symptomatic diagnosis in ALS

Revue neurologiqueJanuary 15, 2020
Philippe Corciaon Behalf the FILSLAN network
1
Bioorganic & Medicinal Chemistry Letters

Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia

Bioorganic & Medicinal Chemistry LettersJanuary 14, 2020
Dean G BrownHeike J Wobst
26
1
Journal of Neuropathology and Experimental Neurology

Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations

Journal of Neuropathology and Experimental NeurologyDecember 18, 2019
Lilah M BesserPeter T Nelson
4
1
Frontiers in Cellular Neuroscience

Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43

Frontiers in Cellular NeuroscienceJanuary 11, 2020
Kevin M HarlenThomas E Hughes
15
1
Frontiers in Aging Neuroscience

Globular Glial Tauopathy Type I Presenting as Atypical Progressive Aphasia, With Comorbid Limbic-Predominant Age-Related TDP-43 Encephalopathy

Frontiers in Aging NeuroscienceJanuary 11, 2020
Robert RusinaRadoslav Matej
7
1
Molecular and Cellular Biology

Cdc48/VCP and endocytosis regulate TDP-43 and FUS toxicity and turnover

Molecular and Cellular BiologyNovember 27, 2019
Guangbo LiuJ Ross Buchan
1
1
Rinshō shinkeigaku = Clinical neurology

Molecular mechanism of amyotrophic lateral sclerosis (ALS) from the viewpoint of the formation and degeneration of transactive response DNA-binding protein 43 kDa (TDP-43) inclusions

Rinshō shinkeigaku = Clinical neurologyJanuary 21, 2020
Sou KasaharaOsamu Onodera

See more papers from this feed

Related Feeds

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Age-related Dementia

Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.

© 2020 Meta ULC. All rights reserved
/feed-previews/tdp-43-proteinopathies/d09d5baf-e47b-47bc-86ae-3bf6a327d996