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The Broad Institute - Researcher Network

The Broad Institute - Researcher Network diagram by Vshivkova, Shutterstock
Vshivkova, Shutterstock

The Eli and Edythe L. Broad Institute of MIT and Harvard was launched to gain a better understanding of human health and disease through genomics. Find the latest research from the Broad Institute here.

Top 20 most recent papers

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

NatureFebruary 28, 2020
Cayetano Pleguezuelos-ManzanoHans Clevers
Nature Reviews. Immunology

Defining trained immunity and its role in health and disease

Nature Reviews. ImmunologyMarch 6, 2020
Mihai G NeteaEicke Latz
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Sensitive detection of minimal residual disease in patients treated for early-stage breast cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchMarch 15, 2020
Heather A ParsonsViktor Adalsteinsson
Cold Spring Harbor Perspectives in Biology

A Synthesis Concerning Conservation and Divergence of Cell Types across Epithelia

Cold Spring Harbor Perspectives in BiologyMarch 4, 2020
Daniel T MontoroJayaraj Rajagopal
Blood Advances

Identification of germline variants in adults with hemophagocytic lymphohistiocytosis

Blood AdvancesMarch 10, 2020
Peter G MillerBenjamin L Ebert

Transcriptional mediators of treatment resistance in lethal prostate cancer

bioRxivMarch 20, 2020
Meng Xiao HeEliezer M. Van Allen
Molecular Systems Biology

Programming Escherichia coli to function as a digital display

Molecular Systems BiologyMarch 7, 2020
Jonghyeon ShinChristopher A Voigt
Nature Chemical Biology

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

Nature Chemical BiologyFebruary 22, 2020
Yilong ZouStuart L Schreiber

Connexin 43 hemichannels mediate spatial and temporal disease spread in ALS

bioRxivMarch 15, 2020
Akshata A. AlmadNicholas J. Maragakis
Journal of the American College of Cardiology

Titin Truncating Variants in Adults Without Known Congestive Heart Failure

Journal of the American College of CardiologyMarch 14, 2020
James P PirruccelloAmit V Khera
American Journal of Human Genetics

Population Histories of the United States Revealed through Fine-Scale Migration and Haplotype Analysis

American Journal of Human GeneticsMarch 7, 2020
Chengzhen L DaiAlicia R Martin

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Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Human Vascular Endothelial Cell Atlas: Young & Old

Examining the genomics, transcriptomics, proteomics and metabolomics of the human vascular endothelial cells at the single cell level will help build a single cell atlas of human vascular endothelium, which would give a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues and insights into how changes in the map underlie health and disease of the vascular endothelium from young to old age. Disocver the latest research on the single cell atlas of human vascular endothelial cell atlas here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

LRRK2 and Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Asperger Syndrome

Asperger syndrome (AS), also known as Asperger's, is a developmental disorder characterized by significant difficulties in social interaction and nonverbal communication, along with restricted and repetitive patterns of behavior and interests. Discover the latest research on Asperger syndrome here.

Mechanisms of Axon Degeneration

The mechanism of axonal degeneration is still poorly understood, but studies in animal models have suggested some cellular and molecular mechanisms responsible. The degeneration of axons in the CNS has been found to be characteristic of many neurodegenerative diseases. Discover the latest research on the mechanisms of axon degeneration here.


Coccidioidomycosis is a fungal disease caused by Coccidioides immitis and Coccidioides posadasii. Symptoms include fever, cough and coin lesions. Discover the latest research on Coccidioidomycosis here.

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