The Broad Institute - Researcher Network

The Eli and Edythe L. Broad Institute of MIT and Harvard was launched to gain a better understanding of human health and disease through genomics. Find the latest research from the Broad Institute here.

August 31, 2020
Open Access

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

Circulation. Genomic and Precision Medicine
Akihiro NomuraSekar Kathiresan
August 21, 2020
Open Access

Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research

Proceedings of the National Academy of Sciences of the United States of America
Guoping FengJohn H Morrison
August 28, 2020
Open Access

Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA

Nature Biomedical Engineering
Maturada PatchsungChayasith Uttamapinant
August 29, 2020
Open Access

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

Nature Communications
James M McFarlandAviad Tsherniak
September 8, 2020
Open Access

The Tug1 lncRNA locus is essential for male fertility

Genome Biology
Jordan P LewandowskiJohn L Rinn
September 1, 2020
Open Access

Multi-modal pooled Perturb-CITE-Seq screens in patient models define novel mechanisms of cancer immune evasion

BioRxiv : the Preprint Server for Biology
C. J. FrangiehBenjamin Izar
August 20, 2020
Open Access

Precision design of stable genetic circuits carried in highly-insulated E. coli genomic landing pads

Molecular Systems Biology
Yongjin ParkChristopher A Voigt
September 18, 2020

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect

Science Translational Medicine
Pavan BachireddyCatherine J Wu
September 11, 2020
Open Access

Development of a qualitative real-time RT-PCR assay for the detection of SARS-CoV-2: A guide and case study in setting up an emergency-use, laboratory-developed molecular assay

MedRxiv : the Preprint Server for Health Sciences
Melis N AnahtarSarah E Turbett
September 16, 2020

Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism

Lucas CheadleMichael E Greenberg
September 3, 2020
Open Access

Genome-wide maps of enhancer regulation connect risk variants to disease genes

BioRxiv : the Preprint Server for Biology
J. NasserJesse M Engreitz
September 2, 2020

Genomic predictors of good outcome, recurrence or progression in High grade T1 non-muscle invasive bladder cancer

Cancer Research
Joaquim BellmuntDavid J Kwiatkowski
September 17, 2020

Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing

The New England Journal of Medicine
Julia JoungFeng Zhang
August 23, 2020

The Folate Cycle Enzyme MTHFR is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Cancer Discovery
Angela SuAlexandre Puissant
August 21, 2020
Open Access

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

Nature Communications
Akl C FahedAmit V Khera
August 31, 2020

Pathogenic deep intronic MTM1 variant activates a pseudo-exon encoding a nonsense codon resulting in severe X-linked myotubular myopathy

European Journal of Human Genetics : EJHG
Samantha J BryenSandra T Cooper
September 10, 2020
Open Access

Prebiotics and Community Composition Influence Gas Production of the Human Gut Microbiota

Xiaoqian YuEric J Alm
August 20, 2020
Open Access

De Novo Damaging Variants, Clinical Phenotypes, and Post-Operative Outcomes in Congenital Heart Disease

Circulation. Genomic and Precision Medicine
Marko T BoskovskiChristine E Seidman

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Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.

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