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The Broad Institute - Researcher Network

The Broad Institute - Researcher Network diagram by Vshivkova, Shutterstock
Vshivkova, Shutterstock

The Eli and Edythe L. Broad Institute of MIT and Harvard was launched to gain a better understanding of human health and disease through genomics. Find the latest research from the Broad Institute here.

Top 20 most recent papers
Nature

B cells and tertiary lymphoid structures promote immunotherapy response

NatureJanuary 17, 2020
Beth A HelminkJennifer A Wargo
392
22
2
2
Nature

A brief history of human disease genetics

NatureJanuary 10, 2020
Melina ClaussnitzerMark I McCarthy
984
2
8
4
Cell

Quantitative Proteomics of the Cancer Cell Line Encyclopedia

CellJanuary 25, 2020
David P NusinowSteven P Gygi
161
1
Cell

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

CellJanuary 26, 2020
F Kyle SatterstromJoseph D Buxbaum
241
24
4
Nature Neuroscience

Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein

Nature NeuroscienceDecember 21, 2019
Sali M K FarhanBenjamin M Neale
5
1
Cancer Cell

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Cancer CellJanuary 15, 2020
Kari J KurppaPasi A Jänne
88
Nature Neuroscience

Exome sequencing in schizophrenia-affected parent-offspring trios reveals risk conferred by protein-coding de novo mutations

Nature NeuroscienceJanuary 15, 2020
Daniel P HowriganBenjamin M Neale
11
1
ImmunoHorizons

The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis

ImmunoHorizonsJanuary 26, 2020
Michael R HowittWendy S Garrett
bioRxiv

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

bioRxivDecember 19, 2019
Scott C RitchieMichael Inouye
72
Nature Communications

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

Nature CommunicationsJanuary 11, 2020
Bo LiNir Hacohen
139
bioRxiv

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway

bioRxivJanuary 23, 2020
Chao WangVijay K. Kuchroo
Nature Genetics

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

Nature GeneticsJanuary 22, 2020
Anindita BasakVijay G Sankaran
86
Nature Communications

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

Nature CommunicationsDecember 22, 2019
Joshua M DempsterFrancesco Iorio
103
5
Nature Genetics

ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer

Nature GeneticsJanuary 15, 2020
Guotai XuEneda Toska
73
bioRxiv

In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity

bioRxivJanuary 24, 2020
Allon WagnerNir Yosef
bioRxiv

Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3

bioRxivJanuary 14, 2020
Jessica A HallAlexander Banks
13
Nature

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells

NatureJanuary 24, 2020
Bing ZhangYa-Chieh Hsu
1466
214
2
2
Nature Communications

Rapid and deep-scale ubiquitylation profiling for biology and translational research

Nature CommunicationsJanuary 19, 2020
Namrata D UdeshiSteven A Carr
54
Annals of Neurology

Mendelian randomization study of obesity and cerebrovascular disease

Annals of NeurologyJanuary 25, 2020
Sandro MariniInternational Stroke Genetics Consortium
2
bioRxiv

Single-nucleus RNA-Seq reveals a new type of brown adipocyte regulating thermogenesis

bioRxivJanuary 20, 2020
Wenfei SunChristian Wolfrum

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