TREM2 and Neurodegeneration

Triggering receptor expressed on myeloid cells 2 (TREM2) is an important gene implicated in neurodegenerative disorders like Alzheimer's Disease, Parkinson's Disease, and Frontotemporal Lobar Degeneration. Discover the latest research studying the molecular mechanisms of TREM2 in neurodegeneration here.

July 3, 2020

Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Zhouyi RongHonghua Zheng
January 10, 2020

Longitudinal Basal Forebrain Degeneration Interacts with TREM2/C3 Biomarkers of Inflammation in Presymptomatic Alzheimer's Disease

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Taylor W SchmitzR Nathan Spreng
June 17, 2020
Open Access

Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration

The Journal of Clinical Investigation
Maud GratuzeDavid M Holtzman
September 4, 2019
Open Access

TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding

Journal of Translational Medicine
Can LiuQiang Shu
September 12, 2019
Preprint
Open Access

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC--derived microglia

BioRxiv : the Preprint Server for Biology
Thomas M PiersJennifer M Pocock
September 6, 2019
Comment / Editorial

Bringing Order out of Chaos: Establishing an Epistatic Relationship between CD33 and TREM2

Neuron
Timothy Y Huang, Huaxi Xu
March 11, 2020
Open Access

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

EMBO Molecular Medicine
Kai SchlepckowChristian Haass
June 21, 2019
Open Access

Analysis of dementia-related gene variants in APOE ε4 noncarrying Korean patients with early-onset Alzheimer's disease

Neurobiology of Aging
Jong Eun ParkSang Won Seo
March 14, 2020
Open Access

Sleep disruption exacerbates and prolongs the inflammatory response to traumatic brain injury

Journal of Neurotrauma
Zoe M TappOlga N Kokiko-Cochran
April 7, 2020

Assessment of TREM2 rs75932628 variant's association with Parkinson's disease in a Greek population and meta-analysis of current data

The International Journal of Neuroscience
Efthimios DardiotisGeorgios M Hadjigeorgiou
June 21, 2019
Open Access

Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Liang ShengGuangxu Xu
July 25, 2020
Open Access

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Molecular Neurodegeneration
Nicholas F FitzRadosveta Koldamova
August 16, 2019
Open Access

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

Science Translational Medicine
Yuetiva DemingCarlos Cruchaga
September 19, 2019
Preprint
Open Access

Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome

BioRxiv : the Preprint Server for Biology
Grace E WeberLynn M. Bekris
February 8, 2020

Microglia-Related Gene Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) Is Upregulated in the Substantia Nigra of Progressive Supranuclear Palsy

Movement Disorders : Official Journal of the Movement Disorder Society
Javier Sánchez-Ruiz de GordoaMaite Mendioroz
December 14, 2019

Analysis of Cerebrospinal Fluid Soluble TREM2 and Polymorphisms in Sporadic Parkinson's Disease in a Chinese Population

Journal of Molecular Neuroscience : MN
Guoyou PengPingyi Xu
August 6, 2019
Open Access

A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer's Disease Risk by Modulating Both Amyloid-β Pathology and Neuronal Degeneration

Frontiers in Neuroscience
Mei-Ling TianAlzheimer’s Disease Neuroimaging Initiative
November 30, 2019
Open Access

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

Alzheimer's Research & Therapy
Nicholas J AshtonHenrik Zetterberg

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