TREM2 & Neurodegeneration

Triggering receptor expressed on myeloid cells 2 (TREM2) is an important gene implicated in neurodegenerative disorders like Alzheimer's Disease, Parkinson's Disease, and Frontotemporal Lobar Degeneration. Discover the latest research studying the molecular mechanisms of TREM2 in neurodegeneration here.

December 2, 2021
Preprint
Open Access

A landscape of the genetic and cellular heterogeneity in Alzheimer disease

MedRxiv : the Preprint Server for Health Sciences
L. BraseOscar Harari
November 28, 2021
Open Access

Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([18F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.

International Journal of Molecular Sciences
Tomasz Jan KolanowskiMaciej Kurpisz
November 23, 2021
Preprint
Open Access

A novel TREM2 splice isoform lacking the ligand binding is expressed in brain and shares localization

BioRxiv : the Preprint Server for Biology
B. C. ShawSteven Estus
November 10, 2021

Microglia and its genetics in Alzheimer's Disease.

Current Alzheimer Research
Xinyan LiangZhen Zhao
November 9, 2021
Preprint
Open Access

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

BioRxiv : the Preprint Server for Biology
K. IbanezParamita Chakrabarty
November 6, 2021

Exciting new tools for studying TREM2 in dementia.

Structure
Georgina E Menzies, Megan Torvell
October 29, 2021
Open Access

Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H.

Frontiers in Aging Neuroscience
Kevin P KotredesGareth R Howell
October 29, 2021
Review

Genomics of Alzheimer's disease implicates the innate and adaptive immune systems.

Cellular and Molecular Life Sciences : CMLS
Yihan LiBen J Gu
October 28, 2021
Comment / Editorial
Open Access

The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles.

Brain Communications
A. MallachJennifer M Pocock
October 22, 2021

Identification and Validation of TREM2 in Intracranial Aneurysms.

Genetic Testing and Molecular Biomarkers
Junhao ZhangJinghua Jin
October 18, 2021
Preprint
Open Access

Rare Variant Aggregation in 148,508 Exomes Identifies Genes Associated with Proxy Alzheimer's Disease

MedRxiv : the Preprint Server for Health Sciences
D. P. WightmanDanielle Posthuma
October 13, 2021
Preprint
Open Access

TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques.

BioRxiv : the Preprint Server for Biology
A. A. UpadhyaySteven E. Bosinger
October 5, 2021
Preprint
Open Access

TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

BioRxiv : the Preprint Server for Biology
A. A. UpadhyaySteven E. Bosinger

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