TREM2 & Neurodegeneration

Triggering receptor expressed on myeloid cells 2 (TREM2) is an important gene implicated in neurodegenerative disorders like Alzheimer's Disease, Parkinson's Disease, and Frontotemporal Lobar Degeneration. Discover the latest research studying the molecular mechanisms of TREM2 in neurodegeneration here.

August 25, 2020
Open Access

γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics

The EMBO Journal
Andrea SteinerFranz Hagn
July 3, 2020
Open Access

Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Zhouyi RongHonghua Zheng
June 17, 2020
Open Access

Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration

The Journal of Clinical Investigation
Maud GratuzeDavid M Holtzman
September 30, 2020

Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice

Behavioural Brain Research
Mei-Dan WeiWen-Ying Chen
March 11, 2020
Open Access

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

EMBO Molecular Medicine
Kai SchlepckowChristian Haass
October 24, 2020
Open Access

CELF2 regulates the species-specific alternative splicing of TREM2

Scientific Reports
Motoaki YanaizuYoshihiro Kino
March 14, 2020
Open Access

Sleep Disruption Exacerbates and Prolongs the Inflammatory Response to Traumatic Brain Injury

Journal of Neurotrauma
Zoe M TappOlga N Kokiko-Cochran
June 12, 2020
Preprint
Open Access

Trem2 Y38C Mutation and Loss of Trem2 Impairs Neuronal Synapses in Adult Mice

ResearchSquare
Vaishnavi S. JadhavBruce T Lamb
September 18, 2020
Open Access

Association of rare variants in neurodegenerative genes with familial Alzheimer's disease

Annals of Clinical and Translational Neurology
Weiwei ZhangLu Shen
October 16, 2020
Preprint
Open Access

Phospholipid Composition of APOE Lipoproteins Affects Microglia Activation in an Isoform-specific Manner

ResearchSquare
Nicholas F FitzRadosveta Koldamova
August 26, 2020

APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease

Acta Neuropathologica
Aivi T NguyenEdward B Lee
August 28, 2020
Open Access

Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype

International Journal of Molecular Sciences
Huifangjie LiJinbin Xu
July 25, 2020
Open Access

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Molecular Neurodegeneration
Nicholas F FitzRadosveta Koldamova
September 17, 2020
Open Access

Novel variants in POLH and TREM2 genes associated with a complex phenotype of xeroderma pigmentosum variant type and early-onset dementia

Molecular Genetics & Genomic Medicine
Izadora Fonseca Zaiden SoaresAlzira Alves de Siqueira Carvalho
September 23, 2020
Open Access

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Human Molecular Genetics
Wenfei LiuDervis A Salih
September 25, 2020
Preprint
Open Access

NEBULA: a fast negative binomial mixed model for differential expression and co-expression analyses of large-scale multi subject single-cell data

BioRxiv : the Preprint Server for Biology
Liang He, A. Kulminski

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