Type 2 Diabetes (Preprints)

This feed focuses on Type 2 Diabetes, a disease where the body doesn’t produce or respond to insulin anymore, leading to abnormal glucose levels in the blood.

February 21, 2021
Preprint
Open Access

Insulin-dependent maturation of newly generated olfactory sensory neurons after injury

BioRxiv : the Preprint Server for Biology
A. KubokiT. Yamasoba
February 2, 2021
Preprint
Open Access

Regenerating insulin-producing β-cells ectopically from a mesodermal origin in the absence of endothelial specification

BioRxiv : the Preprint Server for Biology
K.-C. LiuOlov Andersson
January 29, 2021
Preprint
Open Access

Generation of a novel Nkx6-1 Venus fusion reporter mouse line

BioRxiv : the Preprint Server for Biology
I. BurtscherHeiko Lickert
January 26, 2021
Preprint
Open Access

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

BioRxiv : the Preprint Server for Biology
B. J. GonzalezDieter Egli
January 17, 2021
Preprint
Open Access

The Cardiolipin Transacylase Tafazzin Regulates Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets from Mice

BioRxiv : the Preprint Server for Biology
L. K. ColeGrant Hatch
January 11, 2021
Preprint
Open Access

Mitofusins 1 and 2 collaborate to fuel pancreatic beta cell insulin release via regulation of both mitochondrial structure and DNA content

BioRxiv : the Preprint Server for Biology
V. SidaralaScott A Soleimanpour
January 5, 2021
Preprint
Open Access

FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction

BioRxiv : the Preprint Server for Biology
John L DienerJ. Gao
December 23, 2020
Preprint
Open Access

Diffusion of metabolites across gap junctions mediates metabolic coordination of β-islet cells

BioRxiv : the Preprint Server for Biology
V. P. Rao, Megan A. Rizzo
December 19, 2020
Preprint
Open Access

Autonomous sensing the insulin peptide by an olfactory G protein coupled receptor modulates glucose metabolism

BioRxiv : the Preprint Server for Biology
J. ChengXiao Yu
December 6, 2020
Preprint
Open Access

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes

BioRxiv : the Preprint Server for Biology
L. WiggerMichele Solimena
December 4, 2020
Preprint
Open Access

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β-cells

BioRxiv : the Preprint Server for Biology
R. J. BevacquaSeung K. Kim
December 3, 2020
Preprint
Open Access

Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity

BioRxiv : the Preprint Server for Biology
A. MadhavanLuke Wiseman
December 2, 2020
Preprint
Open Access

Primary cilia sensitize insulin receptor-mediated negative feedback in pancreatic β cells

BioRxiv : the Preprint Server for Biology
Y. LiYi I Wu
November 26, 2020
Preprint
Open Access

AKAP79/150 coordinates leptin-induced PKA activation to regulate KATP channel trafficking in pancreatic β-cells

BioRxiv : the Preprint Server for Biology
V. CochraneShow-Ling Shyng
November 25, 2020
Preprint
Open Access

Glucolipotoxicity-induced Mig6 desensitizes EGFR signaling and promotes pancreatic beta cell death

BioRxiv : the Preprint Server for Biology
Y.-C. ChenPatrick T Fueger
November 12, 2020
Preprint
Open Access

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

MedRxiv : the Preprint Server for Health Sciences
T. G. RichardsonMichael V Holmes
November 2, 2020
Preprint
Open Access

Glucose and NAADP trigger elementary intracellular β cell Ca2+ signals

BioRxiv : the Preprint Server for Biology
Paula M. S. HeisterA. Galione

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