Type 2 Diabetes (Preprints)

This feed focuses on Type 2 Diabetes, a disease where the body doesn’t produce or respond to insulin anymore, leading to abnormal glucose levels in the blood.

September 18, 2019
Preprint
Open Access

Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and function

BioRxiv : the Preprint Server for Biology
Ruiying HuGuoqiang Gu
October 24, 2019
Preprint
Open Access

Amyloid damage to islet β-cells in type 2 diabetes: hypoxia or pseudo-hypoxia?

BioRxiv : the Preprint Server for Biology
Vittorio BellottiMaurizio Parola
September 12, 2019
Preprint
Open Access

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetes

BioRxiv : the Preprint Server for Biology
Jinsook SonAndrea Califano
March 29, 2020
Preprint
Open Access

Efficient detection of pre-proinsulin by double antibody sandwich ELISA

BioRxiv : the Preprint Server for Biology
Zhu ZhuPeng Wang
October 1, 2019
Preprint
Open Access

Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth

BioRxiv : the Preprint Server for Biology
Ming LiuDavid A. Ostrov
December 12, 2019
Open Access

Islet architecture controls synchronous β cell response to glucose in the intact mouse pancreas in vivo

BioRxiv : the Preprint Server for Biology
Melissa T. AdamsBarak Blum
September 30, 2019
Preprint
Open Access

GLP-1(9-36) mediates the glucagonostatic effect of GLP-1 by promiscuous activation of the glucagon receptor

BioRxiv : the Preprint Server for Biology
Claudia GuidaReshma Ramracheya
December 19, 2019
Open Access

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

BioRxiv : the Preprint Server for Biology
Katrina ViloriaD. Hodson
December 23, 2019
Open Access

Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis and β-cell mass decline in mouse models of type 1 diabetes

BioRxiv : the Preprint Server for Biology
David G RamirezRichard KP Benninger
January 3, 2020
Preprint
Open Access

Chop/Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosis

BioRxiv : the Preprint Server for Biology
Jing YongRandal J. Kaufman
September 12, 2019
Preprint
Open Access

β-cells operate collectively to help maintain glucose homeostasis

BioRxiv : the Preprint Server for Biology
Boris PodobnikMarko Jusup
October 31, 2019
Preprint
Open Access

Air pollution mediates diabetes by disrupting gut innate mucosal immunity

BioRxiv : the Preprint Server for Biology
Angela J. T. BoschClaudia Cavelti-Weder
September 24, 2019
Preprint
Open Access

PANCREATIC ISLETS COMMUNICATE WITH THE BRAIN VIA VAGAL SENSORY NEURONS

BioRxiv : the Preprint Server for Biology
Madina MakhmutovaAlejandro Caicedo
June 9, 2020
Preprint
Open Access

Mitophagy protects beta cells from inflammatory damage in diabetes

BioRxiv : the Preprint Server for Biology
V. SidaralaScott A Soleimanpour
September 8, 2019
Preprint
Open Access

Cigarette Smoke Exposure Impairs β-Cell Function Through Activation of Oxidative Stress and Ceramide Accumulation

BioRxiv : the Preprint Server for Biology
Xin TongTatsuyoshi Kono
September 25, 2019
Preprint
Open Access

The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

BioRxiv : the Preprint Server for Biology
Elizabeth HaythorneGuy A Rutter
October 21, 2019
Preprint
Open Access

A transcriptional regulatory atlas of human pancreatic islets reveals non-coding functional signatures at GWAS loci

BioRxiv : the Preprint Server for Biology
Arushi VarshneyStephen C.J. Parker
November 14, 2019
Preprint
Open Access

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

BioRxiv : the Preprint Server for Biology
John T WalkerMarcela Brissova
October 8, 2019
Preprint
Open Access

Physical fitness in community dwelling older adults is linked to dietary intake, gut microbiota and metabolomic signatures

BioRxiv : the Preprint Server for Biology
Josué L. Castro-MejíaDennis S. Nielsen
March 11, 2020
Preprint
Open Access

Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices

BioRxiv : the Preprint Server for Biology
Jurij DolenšekAndraž Stožer

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