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Ubiquitin System

Ubiquitin System diagram by Rogerdodd, Wikimedia
Rogerdodd, Wikimedia

Ubiquitin is a small regulatory protein that is attached to proteins as a post-translational modification in a process known as ubiquitination to regulate protein turnover, location, or activity. Here is the latest research on the ubiquitin system.

Top 20 most recent papers

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

CellJanuary 21, 2020
George M Burslem, Craig M Crews
Nature Communications

Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

Nature CommunicationsJanuary 18, 2020
Kerrie L MariePravin J Mishra
Nature Communications

Rapid and deep-scale ubiquitylation profiling for biology and translational research

Nature CommunicationsJanuary 19, 2020
Namrata D UdeshiSteven A Carr
The Journal of Clinical Investigation

Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer

The Journal of Clinical InvestigationJanuary 22, 2020
Yadong XieHui Xiao
Cell Death & Disease

NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter

Cell Death & DiseaseJanuary 22, 2020
Dong-Eun LeeHeesun Cheong
Current Biology : CB

A Cycle of Ubiquitination Regulates Adaptor Function of the Nedd4-Family Ubiquitin Ligase Rsp5

Current Biology : CBJanuary 21, 2020
Chris MacDonaldRobert C Piper
The Journal of Biological Chemistry

Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer

The Journal of Biological ChemistryJanuary 22, 2020
Xianzhou SongHuamin Wang

A general in vitro assay to study enzymatic activities of the ubiquitin system

BiochemistryJanuary 18, 2020
Yukun ZuoYu Ye
Autism Research : Official Journal of the International Society for Autism Research

Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion

Autism Research : Official Journal of the International Society for Autism ResearchJanuary 22, 2020
Andie DodgeKevin R Nash
Cancer Research

A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-bisphosphatase Enables Hepatic and Renal Tumorigenesis

Cancer ResearchJanuary 18, 2020
Kun LiaoBo Li

Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy

CellsJanuary 19, 2020
M ManirujjamanSachiko Matsuhashi
Scientific Reports

Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation

Scientific ReportsJanuary 22, 2020
Sylwia JonesDaniel Hochhauser
Nature Communications

Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2

Nature CommunicationsJanuary 19, 2020
Zhang-Sen ZhouBao-Liang Song

Response to Comment on Liu et al. Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes 2017;66:689-698

DiabetesJanuary 22, 2020
Bin Liu, Yan Lu
Molecular Oncology

NEK2 Induces Autophagy-mediated Bortezomib Resistance by Stabilizing Beclin-1 in Multiple Myeloma

Molecular OncologyJanuary 20, 2020
Jiliang XiaWen Zhou
Nature Communications

Tunable light and drug induced depletion of target proteins

Nature CommunicationsJanuary 18, 2020
Wen DengHeinrich Leonhardt
Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells

Biochimica Et Biophysica Acta. Molecular and Cell Biology of LipidsJanuary 19, 2020
Mariam AlsanafiSusan Pyne

Comment on Liu et al. Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes 2017;66:689-698

DiabetesJanuary 22, 2020
Siauyen WongDingbo Lin
Cell Death and Differentiation

Prolyl hydroxylase 3 controls the intestine goblet cell generation through stabilizing ATOH1

Cell Death and DifferentiationJanuary 22, 2020
Yi-Ming XuJing Fang
Journal of Dairy Science

Proteasome activity and expression of mammalian target of rapamycin signaling factors in skeletal muscle of dairy cows supplemented with conjugated linoleic acids during early lactation

Journal of Dairy ScienceJanuary 20, 2020
Y YangH Sauerwein

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