Ubiquitin System

Ubiquitin is a small regulatory protein that is attached to proteins as a post-translational modification in a process known as ubiquitination to regulate protein turnover, location, or activity. Here is the latest research on the ubiquitin system.

April 18, 2021

SAGA and SAGA-like SLIK transcriptional coactivators are structurally and biochemically equivalent.

The Journal of Biological Chemistry
Klaudia AdamusDominika Elmlund
April 18, 2021

Polychlorinated Biphenyl Congener 180 (PCB 180) Regulates Mitotic Clonal Expansion and Enhances Adipogenesis through Modulation of C/EBPβ SUMOylation in Preadipocytes.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Caixia YuXinni Xie
April 18, 2021

Self-stabilizing regulation of deubiquitinating enzymes in an enzymatic activity-dependent manner.

International Journal of Biological Macromolecules
Zhenzhu HouLisheng Li
April 18, 2021

RNF168 promotes RHOC degradation by ubiquitination to restrain gastric cancer progression via decreasing HDAC1 expression.

Biochemical and Biophysical Research Communications
Ying XuQianjun Li
April 17, 2021
Preprint
Open Access

Engineering single pan-specific ubiquibodies for targeted degradation of all forms of endogenous ERK protein kinase

BioRxiv : the Preprint Server for Biology
E. A. StephensMatthew P DeLisa
April 18, 2021

Glucose-induced decrease of cystathionine β-synthase mediates renal injuries.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Yanting YuXiaoyan Wang
April 18, 2021
Open Access

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells.

Cell Death Discovery
Ariadna RecasensLenka Munoz
April 17, 2021

Conserved Proline Residues in the Coiled Coil-OB Domain Linkers of Rpt Proteins Facilitate Eukaryotic Proteasome Base Assembly.

The Journal of Biological Chemistry
Chin Leng ChengMark Hochstrasser
April 17, 2021

SPOP suppresses testicular germ cell tumors progression through ubiquitination and degradation of DPPA2.

Biochemical and Biophysical Research Communications
Jian WangXiaofeng Jin
April 16, 2021
Preprint
Open Access

Cullin3 Aggravates The Inflammatory Response of PDLSCs Via Regulation of Shh Signaling and Nrf2

ResearchSquare
Wanhong ChenChun Shi
April 16, 2021

In Silico Identification of Novel Interactions for FABP5 (Fatty Acid-Binding Protein 5) with Nutraceuticals: Possible Repurposing Approach.

Advances in Experimental Medicine and Biology
Ricardo CabezasGeorge E Barreto
April 16, 2021

The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Proteostasis Factors.

Journal of Neuropathology and Experimental Neurology
Benjamin C CreekmoreEdward B Lee
April 16, 2021
Open Access

General Stepwise Approach to Optimize a TR-FRET Assay for Characterizing the BRD/PROTAC/CRBN Ternary Complex.

ACS Pharmacology & Translational Science
Wenwei Lin, Taosheng Chen
April 16, 2021
Open Access

Blood biomarkers for dementia in Hispanic and non-Hispanic White adults.

Alzheimer's & Dementia : Translational Research & Clinical Interventions
Mitzi M GonzalesSudha Seshadri
April 16, 2021
Open Access

SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells.

Frontiers in Cell and Developmental Biology
Lude WangJianlie Yuan

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