Ubiquitination Pathways &Therapeutics

The addition of ubiquitin to a protein substrate via a multistep process is referred to as ubiquitination, which can have a variety of different effects on the protein including flagging the protein for degradation, altering its location or activity, or altering protein-protein interactions. Dysreguation of this pathway has been implicated in multiple disease processes.

October 19, 2020
Preprint
Open Access

Epigenetics of Muscle- and Brain-Specific Expression of KLHL Family Genes

Preprints.org
Kenneth EhrlichMelanie Ehrlich
December 19, 2020
Review
Open Access

The Role of Conformational Dynamics in the Recognition and Regulation of Ubiquitination

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Domarin KhagoRobert Andrew Byrd
October 11, 2020

BES1/BZR1 Homolog 3 (BEH3) cooperates with E3 ligase AtRZF1 to regulate dehydration and brassinosteroid responses

Journal of Experimental Botany
Tinh Van NguyenCheol Soo Kim
October 30, 2020
Review

Current updates and future perspectives on the management of renal cell carcinoma

Life Sciences
Deepika Singh
October 7, 2020
Review
Open Access

The characteristics and roles of β-TrCP1/2 in carcinogenesis

The FEBS Journal
Yanli BiYongchao Zhao
October 23, 2020

Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Mingmin TangXiaoyuan Lian
December 30, 2020
Open Access

Unraveling the MAX2 Protein Network in Arabidopsis thaliana: Identification of the Protein Phosphatase PAPP5 as a Novel MAX2 Interactor

Molecular & Cellular Proteomics : MCP
Sylwia StrukSofie Goormachtig
November 1, 2020
Review
Open Access

Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer's Disease

International Journal of Molecular Sciences
Sudip Dhakal, Ian Macreadie
October 30, 2020
Open Access

USP1 Regulates TAZ Protein Stability Through Ubiquitin Modifications in Breast Cancer

Cancers
Ashley MussellJianmin Zhang
January 13, 2021
Review
Open Access

The role of E3 ubiquitin ligases in the development and progression of glioblastoma

Cell Death and Differentiation
Luke M HumphreysVincenzo D'Angiolella
January 10, 2021
Open Access

Aberrant aggressive behavior in a mouse model of Angelman syndrome

Scientific Reports
Lilach Simchi, Hanoch Kaphzan
January 13, 2021
Open Access

CHIP promotes Wnt signaling and regulates Arc stability by recruiting and polyubiquitinating LEF1 or Arc

Cell Death Discovery
Yuchun LiuShoutao Zhang
December 18, 2020
Open Access

HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory

Frontiers in Neuroanatomy
Eva M Pérez-VillegasJosé A Armengol
October 23, 2020

A kinetic proofreading model for bispecific protein degraders

Journal of Pharmacokinetics and Pharmacodynamics
Derek W Bartlett, Adam M Gilbert
December 10, 2020
Review
Open Access

Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer

BioMed Research International
Jingjing WangGuixiang Tai

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