Ubiquitination Pathways &Therapeutics

The addition of ubiquitin to a protein substrate via a multistep process is referred to as ubiquitination, which can have a variety of different effects on the protein including flagging the protein for degradation, altering its location or activity, or altering protein-protein interactions. Dysreguation of this pathway has been implicated in multiple disease processes.

January 16, 2022

Molecular characteristics and immune function of ubiquitin C-terminal hydrolase-L3 in Macrobrachium nipponense.

Fish & Shellfish Immunology
Tingyao ZhuHaisheng Xu
January 16, 2022

Grouper USP12 exerts antiviral activity against nodavirus infection.

Fish & Shellfish Immunology
Ya ZhangYouhua Huang
January 16, 2022
Review

Ubiquitination regulation of aerobic glycolysis in cancer.

Life Sciences
Yao XieJing Zhong
January 15, 2022

ZC3H15 promotes glioblastoma progression through regulating EGFR stability.

Cell Death & Disease
Jianbing HouHongjuan Cui
January 15, 2022
Open Access

Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease.

Communications Biology
Gabriela NovakAlexander Skupin
January 14, 2022
Open Access

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.

PLoS Genetics
Cécile RibotMartine Simonelig
January 14, 2022

Inhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia neurons.

Brain : a Journal of Neurology
Zhenyu ChenXue-Jun Li
January 14, 2022
Review

F-box only protein 9 and its role in cancer.

Molecular Biology Reports
Shujaat HussainHongmin Liu
January 14, 2022

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase.

IScience
Evgeny ShlevkovLaura F Silvian
January 14, 2022
Open Access

Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression.

Acta Pharmaceutica Sinica. B
Meijia QianQiaojun He
January 14, 2022
Case Report

Bortezomib-Induced Reversible Cardiomyopathy: Recovered With Guideline-Directed Medical Therapy.

Curēus
Swethika H SundaravelJeremy R Stone
January 14, 2022

Apelin-13 Decreases Epithelial Sodium Channel (ENaC) Expression and Activity in Kidney Collecting Duct Cells.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Houda Ayari, Ahmed Chraibi
January 14, 2022

A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease.

Disease Models & Mechanisms
Zhao-Feng LiJian-Hong Zhu

Sign up to follow this feed and discover related papers.

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cell Cycle Control & Proteolysis

Key regulators of cell cycle, including cyclins, cyclin dependent kinase inhibitors, DNA replication factors, are controlled by proteolysis. Discover the latest research on cell cycle control and proteolysis.

Cell Cycle Modeling

Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur. Discover the latest research on cell cycle modeling here.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Centromere in DNA replication

Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms. Discover the latest research on centromere in DNA replication here.

Centromeres & Kinetochores

The centromere is a specialized DNA sequence of a chromosome that links a pair of sister chromatids. During prophase, specialized regions of the centromeres known as kinetochores attach chromosomes to spindle fibers. Here is the latest research on centromeres and the kinetochore.

Collective Cell Migration

Collective cell migration is the coordinated movement of cells, which organize tissues during morphogenesis, repair and some cancers. Here is the latest research.

Cyclins & Cyclin-dependent Kinases

Cyclins and cylin-dependent kinases (CDKs) are two classes of regulatory molecules that determine a cell’s progression through cell cycle. Here is the latest research.

Embryogenesis

Embryogenesis is the process by which the embryo forms and develops. It starts with the fertilization of the egg cell (ovum) by a sperm cell, (spermatozoon). Once fertilized, the ovum is referred to as a zygote, a single diploid cell. The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo

Endoterm Organogenesis

During organogenesis, the endoderm of vertebrates produces tissue within the lungs, thyroid, and pancreas

© 2022 Meta ULC. All rights reserved
/feed-previews/ubiquitination-pathways-therapeutics/21eed1e9-c155-4f95-9f29-432d93d00451