Ubiquitination Pathways &Therapeutics

The addition of ubiquitin to a protein substrate via a multistep process is referred to as ubiquitination, which can have a variety of different effects on the protein including flagging the protein for degradation, altering its location or activity, or altering protein-protein interactions. Dysreguation of this pathway has been implicated in multiple disease processes.

April 25, 2020
Open Access

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System

International Journal of Molecular Sciences
Weigang LiuHuaijun Si
June 24, 2020

Manumycin polyketides act as molecular glues between UBR7 and P53

Nature Chemical Biology
Yosuke IsobeDaniel K Nomura
June 3, 2020
Open Access

Long non-coding RNAs and TGF-β signaling in cancer

Cancer Science
Panagiotis Papoutsoglou, Aristidis Moustakas
April 23, 2020
Open Access

Post-translational modifications and stress adaptation: the paradigm of FKBP51

Biochemical Society Transactions
Theo Rein
June 14, 2020
Open Access

DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer

Francesca BufalieriLucia Di Marcotullio
July 1, 2020

Comprehensive investigation into the role of ubiquitin conjugating enzyme E2S (UBE2S) in melanoma development

The Journal of Investigative Dermatology
Ping WangAie Xu
May 6, 2020

Expression and Retention of Thymidine Phosphorylase in Cultured Reticulocytes as a Novel Treatment for MNGIE

Molecular Therapy. Methods & Clinical Development
Marjolein MeindersAshley M Toye
May 6, 2020
Open Access

IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling

Baptiste DumétierLaurence Dubrez
May 30, 2020
Open Access

Dual functions of Rack1 in regulating Hedgehog pathway

Cell Death and Differentiation
Yan LiZizhang Zhou
June 20, 2020

Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins

Cell Reports
Caleb D SwaimJon M Huibregtse
May 8, 2020

An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ling XuYong-Gang Yao
April 28, 2020

Transgenic expression of Sag/Rbx2 E3 causes early stage tumor promotion, late stage cytogenesis and acinar loss in the Kras-PDAC model

Neoplasia : an International Journal for Oncology Research
Qiang ZhangYi Sun
April 24, 2020

Disruption of the polyubiquitin gene Ubb reduces the self-renewal capacity of neural stem cells

Biochemical and Biophysical Research Communications
Chul-Woo ParkKwon-Yul Ryu
June 18, 2020
Open Access

BK Channel Dysfunction in Diabetic Coronary Artery: Role of the E3 Ubiquitin Ligases

Frontiers in Physiology
Ling-Ling QianRu-Xing Wang
June 20, 2020

A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5

PLoS Genetics
Chalita WashingtonCathie M Pfleger
May 1, 2020
Open Access

P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint

Cell Discovery
Yang WangJinke Cheng
May 28, 2020

Jab1 promotes gastric cancer tumorigenesis via non-ubiquitin proteasomal degradation of p14ARF

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Lin WangDong-Sheng Pei
June 6, 2020
Open Access

Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock

Current Biology : CB
Maite OguetaRalf Stanewsky

Sign up to follow this feed and discover related papers.

Related Feeds

Autophagy: Cancer & Parkinson

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in cancer and Parkinson’s.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cell Cycle Control & Proteolysis

Key regulators of cell cycle, including cyclins, cyclin dependent kinase inhibitors, DNA replication factors, are controlled by proteolysis. Discover the latest research on cell cycle control and proteolysis.

Cell Cycle Modeling

Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur. Discover the latest research on cell cycle modeling here.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Centromere in DNA replication

Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms. Discover the latest research on centromere in DNA replication here.

Centromeres & Kinetochores

The centromere is a specialized DNA sequence of a chromosome that links a pair of sister chromatids. During prophase, specialized regions of the centromeres known as kinetochores attach chromosomes to spindle fibers. Here is the latest research on centromeres and the kinetochore.

Collective Cell Migration

Collective cell migration is the coordinated movement of cells, which organize tissues during morphogenesis, repair and some cancers. Here is the latest research.

Cyclins & Cyclin-dependent Kinases

Cyclins and cylin-dependent kinases (CDKs) are two classes of regulatory molecules that determine a cell’s progression through cell cycle. Here is the latest research.


Embryogenesis is the process by which the embryo forms and develops. It starts with the fertilization of the egg cell (ovum) by a sperm cell, (spermatozoon). Once fertilized, the ovum is referred to as a zygote, a single diploid cell. The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo

© 2020 Meta ULC. All rights reserved