Ubiquitination Pathways &Therapeutics

The addition of ubiquitin to a protein substrate via a multistep process is referred to as ubiquitination, which can have a variety of different effects on the protein including flagging the protein for degradation, altering its location or activity, or altering protein-protein interactions. Dysreguation of this pathway has been implicated in multiple disease processes.

October 19, 2020
Open Access

Epigenetics of Muscle- and Brain-Specific Expression of KLHL Family Genes

Kenneth EhrlichMelanie Ehrlich
December 19, 2020
Open Access

The Role of Conformational Dynamics in the Recognition and Regulation of Ubiquitination

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Domarin KhagoRobert Andrew Byrd
October 11, 2020

BES1/BZR1 Homolog 3 (BEH3) cooperates with E3 ligase AtRZF1 to regulate dehydration and brassinosteroid responses

Journal of Experimental Botany
Tinh Van NguyenCheol Soo Kim
October 30, 2020

Current updates and future perspectives on the management of renal cell carcinoma

Life Sciences
Deepika Singh
October 7, 2020
Open Access

The characteristics and roles of β-TrCP1/2 in carcinogenesis

The FEBS Journal
Yanli BiYongchao Zhao
October 23, 2020

Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Mingmin TangXiaoyuan Lian
December 30, 2020
Open Access

Unraveling the MAX2 Protein Network in Arabidopsis thaliana: Identification of the Protein Phosphatase PAPP5 as a Novel MAX2 Interactor

Molecular & Cellular Proteomics : MCP
Sylwia StrukSofie Goormachtig
November 1, 2020
Open Access

Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer's Disease

International Journal of Molecular Sciences
Sudip Dhakal, Ian Macreadie
October 30, 2020
Open Access

USP1 Regulates TAZ Protein Stability Through Ubiquitin Modifications in Breast Cancer

Ashley MussellJianmin Zhang
January 13, 2021
Open Access

The role of E3 ubiquitin ligases in the development and progression of glioblastoma

Cell Death and Differentiation
Luke M HumphreysVincenzo D'Angiolella
January 10, 2021
Open Access

Aberrant aggressive behavior in a mouse model of Angelman syndrome

Scientific Reports
Lilach Simchi, Hanoch Kaphzan
January 13, 2021
Open Access

CHIP promotes Wnt signaling and regulates Arc stability by recruiting and polyubiquitinating LEF1 or Arc

Cell Death Discovery
Yuchun LiuShoutao Zhang
December 18, 2020
Open Access

HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory

Frontiers in Neuroanatomy
Eva M Pérez-VillegasJosé A Armengol
October 23, 2020

A kinetic proofreading model for bispecific protein degraders

Journal of Pharmacokinetics and Pharmacodynamics
Derek W Bartlett, Adam M Gilbert
December 10, 2020
Open Access

Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer

BioMed Research International
Jingjing WangGuixiang Tai

Sign up to follow this feed and discover related papers.

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cell Cycle Control & Proteolysis

Key regulators of cell cycle, including cyclins, cyclin dependent kinase inhibitors, DNA replication factors, are controlled by proteolysis. Discover the latest research on cell cycle control and proteolysis.

Cell Cycle Modeling

Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur. Discover the latest research on cell cycle modeling here.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Centromere in DNA replication

Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms. Discover the latest research on centromere in DNA replication here.

Centromeres & Kinetochores

The centromere is a specialized DNA sequence of a chromosome that links a pair of sister chromatids. During prophase, specialized regions of the centromeres known as kinetochores attach chromosomes to spindle fibers. Here is the latest research on centromeres and the kinetochore.

Collective Cell Migration

Collective cell migration is the coordinated movement of cells, which organize tissues during morphogenesis, repair and some cancers. Here is the latest research.

Cyclins & Cyclin-dependent Kinases

Cyclins and cylin-dependent kinases (CDKs) are two classes of regulatory molecules that determine a cell’s progression through cell cycle. Here is the latest research.


Embryogenesis is the process by which the embryo forms and develops. It starts with the fertilization of the egg cell (ovum) by a sperm cell, (spermatozoon). Once fertilized, the ovum is referred to as a zygote, a single diploid cell. The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo

Endoterm Organogenesis

During organogenesis, the endoderm of vertebrates produces tissue within the lungs, thyroid, and pancreas

© 2021 Meta ULC. All rights reserved