Ubiquitination Pathways &Therapeutics

The addition of ubiquitin to a protein substrate via a multistep process is referred to as ubiquitination, which can have a variety of different effects on the protein including flagging the protein for degradation, altering its location or activity, or altering protein-protein interactions. Dysreguation of this pathway has been implicated in multiple disease processes.

January 16, 2022

Molecular characteristics and immune function of ubiquitin C-terminal hydrolase-L3 in Macrobrachium nipponense.

Fish & Shellfish Immunology
Tingyao ZhuHaisheng Xu
January 16, 2022

Grouper USP12 exerts antiviral activity against nodavirus infection.

Fish & Shellfish Immunology
Ya ZhangYouhua Huang
January 16, 2022

Ubiquitination regulation of aerobic glycolysis in cancer.

Life Sciences
Yao XieJing Zhong
January 15, 2022

ZC3H15 promotes glioblastoma progression through regulating EGFR stability.

Cell Death & Disease
Jianbing HouHongjuan Cui
January 15, 2022
Open Access

Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease.

Communications Biology
Gabriela NovakAlexander Skupin
January 14, 2022
Open Access

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.

PLoS Genetics
Cécile RibotMartine Simonelig
January 14, 2022

Inhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia neurons.

Brain : a Journal of Neurology
Zhenyu ChenXue-Jun Li
January 14, 2022

F-box only protein 9 and its role in cancer.

Molecular Biology Reports
Shujaat HussainHongmin Liu
January 14, 2022

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase.

Evgeny ShlevkovLaura F Silvian
January 14, 2022
Open Access

Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression.

Acta Pharmaceutica Sinica. B
Meijia QianQiaojun He
January 14, 2022
Case Report

Bortezomib-Induced Reversible Cardiomyopathy: Recovered With Guideline-Directed Medical Therapy.

Swethika H SundaravelJeremy R Stone
January 14, 2022

Apelin-13 Decreases Epithelial Sodium Channel (ENaC) Expression and Activity in Kidney Collecting Duct Cells.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Houda Ayari, Ahmed Chraibi
January 14, 2022

A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease.

Disease Models & Mechanisms
Zhao-Feng LiJian-Hong Zhu

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