V(D)J Recombination

V(D)J recombination is the specialized DNA rearrangement used by cells of the immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting gene segments. Here is the latest research.

June 12, 2020
Open Access

Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion

The Journal of Experimental Medicine
Glendon S WuCraig H Bassing
September 2, 2020
Open Access

Structure-Altering Mutations of the SARS-CoV-2 Frame Shifting RNA Element

BioRxiv : the Preprint Server for Biology
Tamar SchlickShuting Yan
May 1, 2020
Open Access

Co-evolution of mutagenic genome editors and vertebrate adaptive immunity

Current Opinion in Immunology
Inês TrancosoThomas Boehm
July 22, 2020
Open Access

Inefficient V(D)J recombination underlies monogenic T cell receptor β expression

Proceedings of the National Academy of Sciences of the United States of America
Glendon S Wu, Craig H Bassing
September 26, 2020

Reading the B cell receptor Immunome in Chronic Lymphocytic Leukemia: Revelations and Applications

Experimental Hematology
Paul J HengeveldAnton W Langerak
September 25, 2020

IL-7R signalling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells

BioRxiv : the Preprint Server for Biology
A. Baizan EdgeAnne E Corcoran
September 7, 2020
Open Access

Leaky Severe Combined Immunodeficiency in Mice Lacking Non-homologous End Joining Factors XLF and MRI

Sergio Castañeda-ZegarraValentyn Oksenych
July 24, 2020
Open Access

Brain cell somatic gene recombination and its phylogenetic foundations

The Journal of Biological Chemistry
Gwendolyn Kaeser, Jerold Chun
September 19, 2020

Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase

The EMBO Journal
Yuhang ZhangDavid G Schatz
June 17, 2020
Open Access

An Erg-driven transcriptional program controls B cell lymphopoiesis

Nature Communications
Ashley P NgWarren S Alexander
September 3, 2020

Non-canonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis

American Journal of Physiology. Lung Cellular and Molecular Physiology
Rakhshinda RehmanUlaganathan Mabalirajan
July 3, 2020

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion

Louisa HillMeinrad Busslinger
September 5, 2020
Open Access

ZnC2 module of RAG1 Contributes towards Structure-specific Nuclease activity of RAGs

The Biochemical Journal
Namrata M NilavarSathees C Raghavan
August 15, 2020
Open Access

Mouse Models of c-myc Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis

Frontiers in Immunology
Melissa FerradYves Denizot

Sign up to follow this feed and discover related papers.

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibody synthesis

Antibodies have various functions including neutralization of pathogens, tumor targeting, as well as its utility in biomedical research. Here is the latest research on antibody synthesis.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

© 2020 Meta ULC. All rights reserved