V(D)J Recombination

V(D)J recombination is the specialized DNA rearrangement used by cells of the immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting gene segments. Here is the latest research.

October 15, 2021
Open Access

The CRL4VPRBP(DCAF1) E3 ubiquitin ligase directs constitutive RAG1 degradation in a non-lymphoid cell line.

PloS One
N Max Schabla, Patrick C Swanson
October 14, 2021

RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination.

Cell Reports
Tingting GanJiazhi Hu
October 4, 2021
Open Access

Could β-Lactam Antibiotics Block Humoral Immunity?

Frontiers in Immunology
Cléa MelenotteDidier Raoult
September 29, 2021

Analysis of T cell receptor clonotypes in tumor microenvironment identifies shared cancer-type-specific signatures.

Cancer Immunology, Immunotherapy : CII
Yvonne H F TengN Gopalakrishna Iyer
September 23, 2021

TCRβ rearrangements without a D segment are common, abundant, and public.

Proceedings of the National Academy of Sciences of the United States of America
Peter C de Greef, Rob J de Boer
September 20, 2021
Open Access

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

BioRxiv : the Preprint Server for Biology
Magdalena L RussellP. G. Bradley
September 9, 2021

Using DNA sequencing data to quantify T cell fraction and therapy response.

Robert BenthamNicholas McGranahan
September 5, 2021
Open Access

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

BioRxiv : the Preprint Server for Biology
M. GhraichyJ. Trück
September 2, 2021
Case Report

Genetic features of precursor B-cell phenotype Burkitt leukemia with IGH-MYC rearrangement.

Cancer Reports
Masanori YoshidaMotohiro Kato
August 18, 2021

The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination.

The Journal of Experimental Medicine
Helen A BeilinsonDavid G Schatz
August 16, 2021
Open Access

Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination.

Frontiers in Immunology
Iryna YakovenkoMatan Oren

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