V(D)J Recombination

V(D)J recombination is the specialized DNA rearrangement used by cells of the immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting gene segments. Here is the latest research.

June 12, 2020
Open Access

Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion

The Journal of Experimental Medicine
Glendon S WuCraig H Bassing
September 2, 2020
Preprint
Open Access

Structure-Altering Mutations of the SARS-CoV-2 Frame Shifting RNA Element

BioRxiv : the Preprint Server for Biology
Tamar SchlickShuting Yan
May 1, 2020
Review
Open Access

Co-evolution of mutagenic genome editors and vertebrate adaptive immunity

Current Opinion in Immunology
Inês TrancosoThomas Boehm
July 22, 2020
Open Access

Inefficient V(D)J recombination underlies monogenic T cell receptor β expression

Proceedings of the National Academy of Sciences of the United States of America
Glendon S Wu, Craig H Bassing
September 26, 2020
Review

Reading the B cell receptor Immunome in Chronic Lymphocytic Leukemia: Revelations and Applications

Experimental Hematology
Paul J HengeveldAnton W Langerak
September 25, 2020
Preprint

IL-7R signalling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells

BioRxiv : the Preprint Server for Biology
A. Baizan EdgeAnne E Corcoran
September 7, 2020
Preprint
Open Access

Leaky Severe Combined Immunodeficiency in Mice Lacking Non-homologous End Joining Factors XLF and MRI

Preprints.org
Sergio Castañeda-ZegarraValentyn Oksenych
July 24, 2020
Review
Open Access

Brain cell somatic gene recombination and its phylogenetic foundations

The Journal of Biological Chemistry
Gwendolyn Kaeser, Jerold Chun
September 19, 2020

Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase

The EMBO Journal
Yuhang ZhangDavid G Schatz
June 17, 2020
Open Access

An Erg-driven transcriptional program controls B cell lymphopoiesis

Nature Communications
Ashley P NgWarren S Alexander
September 3, 2020

Non-canonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis

American Journal of Physiology. Lung Cellular and Molecular Physiology
Rakhshinda RehmanUlaganathan Mabalirajan
July 3, 2020

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion

Nature
Louisa HillMeinrad Busslinger
September 5, 2020
Open Access

ZnC2 module of RAG1 Contributes towards Structure-specific Nuclease activity of RAGs

The Biochemical Journal
Namrata M NilavarSathees C Raghavan
August 15, 2020
Review
Open Access

Mouse Models of c-myc Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis

Frontiers in Immunology
Melissa FerradYves Denizot

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