α- and γ-mangostin cause shape changes, inhibit aggregation and induce cytolysis of rat platelets

Chemico-biological Interactions
Yingqiu LiuMoo-Yeol Lee

Abstract

α- and γ-mangostin are natural xanthones isolated from mangosteen (Garcinia mangostana) and the major constituents responsible for the plant's diverse biological activities. In this study, the effects of α- and γ-mangostin on platelets were investigated based on their possible antiplatelet activity. Treatment of isolated platelets with α-mangostin resulted in attenuation of platelet aggregatory response to collagen, thrombin or ADP. Such antiaggregatory effects were concentration-dependent in ranges of 1-10 μM. Interestingly, α-mangostin alone induced shape changes in platelets at the same concentration, and higher levels, 25 and 50 μM caused platelet lysis. Similarly, γ-mangostin induced shape changes and inhibited aggregation at 2.5-25 μM, while 50 and 100 μM γ-mangostin exhibited cytotoxicity. Platelet shape change induced by α- and γ-mangostin was accompanied by increases in myosin light chain (MLC) phosphorylation. MLC phosphorylation and subsequent shape changes were prevented by pretreatment with Rho kinase (ROCK) inhibitor Y-27632, but not by the intracellular Ca(2+) chelating with BAPTA-AM and extracellular Ca(2+) removal. Cytolysis by both α- and γ-mangostin was abolished in the absence of extracellular Ca(2+). Taken ...Continue Reading

References

May 1, 1996·Toxicology and Applied Pharmacology·K A KimJ H Chung
Jul 10, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E MasiniP F Mannaioni
May 7, 1999·Environmental Health Perspectives·G E Kass, S Orrenius
May 22, 2004·Journal of Pharmacological Sciences·Ayumi SatoYasushi Ohizumi
Aug 23, 2005·Bioorganic & Medicinal Chemistry·Kenji MatsumotoYoshinori Nozawa
Mar 2, 2006·Chemical & Pharmaceutical Bulletin·Sunit SuksamrarnApichart Suksamrarn
Mar 16, 2006·Journal of Agricultural and Food Chemistry·Hyun-Ah JungA Douglas Kinghorn
Aug 2, 2007·Hematology/oncology Clinics of North America·Paul F Bray
Aug 2, 2007·Hematology/oncology Clinics of North America·Yu-Min P Shen, Eugene P Frenkel
Aug 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José Pedraza-ChaverriJazmin M Pérez-Rojas
Nov 28, 2008·Archiv der Pharmazie·Kai-Wei LinChun-Nan Lin
Jan 28, 2009·Phytotherapy Research : PTR·Dmitriy ObolskiyMichael Heinrich
Sep 22, 2009·Free Radical Biology & Medicine·Alzbeta SobotkováJan E Dyr
Oct 7, 2009·Thrombosis and Haemostasis·Peter GunnarssonMagnus Grenegård
Feb 2, 2010·Nature Reviews. Drug Discovery·Alan D Michelson
Jul 31, 2010·Journal of Thrombosis and Haemostasis : JTH·T M GetzS P Kunapuli
Sep 30, 2010·Phytotherapy Research : PTR·Gui-Hua QuanYoung-Won Chin
Aug 16, 2011·Cardiovascular & Hematological Agents in Medicinal Chemistry·Jennifer Yeung, Michael Holinstat
Jan 3, 2012·Thrombosis Research·Francesco Violi, Pasquale Pignatelli
Nov 13, 2012·Current Drug Targets·Atulkumar RamaiyaJeremy J Johnson
Feb 26, 2013·Archives of Pharmacal Research·Seok-Jeong OhMoo-Yeol Lee
Mar 29, 2013·Platelets·Ann-Charlotte B Svensson HolmEva G Lindström

❮ Previous
Next ❯

Citations

Jun 29, 2017·Phytotherapy Research : PTR·Hourieh Tousian ShandizHossein Hosseinzadeh
Jan 4, 2019·Experimental Biology and Medicine·Wannakarn KittipaspallopWittaya Pimtong
Feb 23, 2020·Human Cell·Thi Kieu Trang PhanTakanori Kihara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Canavan Disease

Canavan disease, a type of leukodystrophy, is an autosomal recessive neurodegenerative disorder, and is one of the most common degenerative cerebral diseases of infancy. Discover the latest research on Canavan disease here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.