(-)-Epicatechin inhibits development of dilated cardiomyopathy in δ sarcoglycan null mouse

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Sergio De Los SantosR M Coral-Vázquez

Abstract

Several studies propose that (-)-epicatechin, a flavonol present in high concentration in the cocoa, has cardioprotective effects. This study aimed to evaluate the impact of (-)-epicatechin on the development of dilated cardiomyopathy in a δ sarcoglycan null mouse model. δ Sarcoglycan null mice were treated for 15 days with (-)-epicatechin. Histological and morphometric analysis of the hearts treated mutant mice showed significant reduction of the vasoconstrictions in the coronary arteries as well as fewer areas with fibrosis and a reduction in the loss of the ventricular wall. On the contrary, it was observed a thickening of this region. By Western blot analysis, it was shown, and increment in the phosphorylation level of eNOS and PI3K/AKT/mTOR/p70S6K proteins in the heart of the (-)-epicatechin treated animals. On the other hand, we observed a significantly decreased level of the atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) heart failure markers. All the results indicate that (-)-epicatechin has the potential to prevent the development of dilated cardiomyopathy of genetic origin and encourages the use of this flavonol as a pharmacological therapy for dilated cardiomyopathy and heart failure diseases.

Citations

Jun 11, 2019·Journal of Developmental Origins of Health and Disease·Sergio De Los SantosPatricia Canto
Aug 18, 2020·Food Chemistry·Fábio Fernandes de AraújoGlaucia Maria Pastore
Sep 4, 2020·Journal of Cellular and Molecular Medicine·Shichao LvJunping Zhang

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