(-)-Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related gene expression in broiler chickens

Lipids in Health and Disease
Jing HanH Ma

Abstract

Chicken as a delicious food for a long history, and it is well known that excess fat deposition in broiler chickens will not only induced metabolic diseases, but also lead to adverse effect in the consumer's health. (-)-Hydroxycitric acid (HCA), a major active ingredient of Garcinia Cambogia extracts, had shown to suppress fat accumulation in animals and humans. While, the precise physiological mechanism of HCA has not yet been full clarified, especially its action in broiler chickens. Thus, this study aimed to assess the effect of (-)-HCA on lipid metabolism in broiler chickens. A total of 120 1-day-old broiler chickens were randomly allocated to four groups, with each group was repeated three times with 10 birds. Birds received a commercial diet supplemented with (-)-HCA at 0, 1000, 2000 or 3000 mg/kg, respectively, for a period of 4 weeks ad libitum. Body weight (BW) in the 2000 and 3000 mg/kg (-)-HCA groups was significantly decreased (P < 0.05) than that in control group. A significantly decreased of serum triglyceride (TG) and density lipoprotein-cholesterol (LDL-C) content were observed in 3000 mg/kg (-)-HCA group (P < 0.05). Broiler chickens supplmented with 2000 and 3000 mg/kg (-)-HCA had pronouncedly higher hepatic li...Continue Reading

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Citations

Mar 24, 2018·The British Journal of Nutrition·Zhuang LuFeng Gao
May 28, 2019·Animal Science Journal = Nihon Chikusan Gakkaihō·Shengnan LiHaitian Ma
Aug 15, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Mengling PengHaitian Ma
Dec 17, 2019·Food & Nutrition Research·Muhammad Suhaib ShahidJianmin Yuan
Sep 10, 2019·Progress in Lipid Research·Xiaojun FengAi-Zong Shen

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nuclear translocation
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