Apr 17, 2020

α- Linoleanic acid modulates phagocytosis of extracellular Tau and induces microglial migration by actin-remodeling

BioRxiv : the Preprint Server for Biology
S. E. Desale, Subashchandrabose Chinnathambi

Abstract

Background: Seeding effect of extracellular Tau species is an emerging aspect to study the Tauopathies in Alzheimers disease. Tau seeds enhance the propagation of disease along with its contribution to microglia-mediated inflammation. Omega-3 fatty acids are known to exert the anti-inflammatory property to microglia by modulating cell membrane compositions. The immunomodulatory function of omega-3 fatty acids exerts anti-inflammatory property to microglia. Owing to the imparted anti-inflammatory nature enhance phagocytosis and increased migration property has been observed in microglia. The dietary omega-3 fatty acids are found to change the lipid composition of the cell membrane that predominated many signaling cascade and by modulating specific receptor response. Thus the omega-3 fatty acids influence microglial response in Tauopathy. Methods: N9 microglia cells were exposed to extracellular full-length Tau monomer and aggregates along with ALA (alpha Linolenic acid) to study the internalization of exposed Tau. The degradation of internalized Tau studied with the endosomal markers Rab5 and Rab7. The final degradation step in phagocytosis has been studied with LAMP-2A as lysosomal markers. The changes in the rate of migration ...Continue Reading

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Mentioned in this Paper

Fertility
Biochemical Pathway
Fluctuation
Size
Patterns
Ovum
Genes
Caenorhabditis elegans
PRKAA2 gene
PRKAB1

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