α- (phenylselanyl) acetophenone mitigates reserpine-induced pain-depression dyad: Behavioral, biochemical and molecular docking evidences

Brain Research Bulletin
Fernanda Severo Sabedra SousaLucielli Savegnago

Abstract

Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy. α- (phenylselanyl) acetophenone (PSAP) is an organic selenium compound which has already demonstrated antioxidant, antidepressant and antinociceptive activities in animal models, without showing acute toxicity. In view of develop more effective treatments to comorbid pain and depression, the purpose of this study was to evaluate the behavioral and biochemical effects of PSAP on reserpine induced pain-depression dyad model in mice as well to analyze the interaction of PSAP with specific targets by molecular docking analysis. Reserpine (0.5 mg/kg daily, for 3 days, i.p.) decreased the latency for the first episode of immobility and the swimming time, as well as increased the immobility time of mice in the modified forced swimming test (mFST). Reserpine also led to a significant decrease in nociceptive threshold in thermal hyperalgesia in the hot plate test. PSAP or imipramine (10 mg/kg daily, for 2 days, i.g.) reversed these alterations in both mFST and hot plate test. Additionaly, PSAP reduced nitrite and malondialdehyde (MDA) levels and catalase (CAT)...Continue Reading

Citations

Oct 2, 2019·International Journal of Molecular Sciences·Yuanzhen HaoYun Gao
Aug 28, 2020·Frontiers in Psychology·Ana Carolina Pinheiro CamposRaquel Chacon Ruiz Martinez
Feb 18, 2021·Pain and Therapy·Roberto CasaleAntonella Paladini
Mar 4, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jamal RafiqueAntonio L Braga
Mar 8, 2021·Experimental Brain Research·Lovedeep SinghRajbir Bhatti
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida
Jul 16, 2021·Pharmacology & Therapeutics·Evelyne Silva BrumSara Marchesan Oliveira

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