β-1,3-glucanase disrupts biofilm formation and increases antifungal susceptibility of Candida albicans DAY185

International Journal of Biological Macromolecules
Yulong TanBerit Schneider-Stickler

Abstract

β-1,3-glucan plays a role in Candida biofilm formation and survival of biofilm-forming Candida to stresses. In this study, we evaluated the antibiofilm activity of β-1,3-glucanase, which can degrade poly-β(1→3)-glucose of Candida albicans biofilms. Biofilm was dispersed by 55.96%. β-1,3-glucanase had no effect on Candida planktonic growth as well as adhesion. β-1,3-glucanase markedly enhanced the antifungal susceptibility of fluconazole and amphotericin B. The examination using confocal laser scanning microscopy and scanning electron microscope confirmed the antibiofilm activity of β-1,3-glucanase. Our findings demonstrate that β-1,3-glucanase may be useful as an antibiofilm agent.

Citations

May 19, 2018·Journal of Fungi·Peter N Lipke
Nov 2, 2019·MSphere·Suresh AmbatiRichard B Meagher
Dec 3, 2020·Frontiers in Microbiology·Carmen Rodríguez-CerdeiraJosé Luís González-Cespón
Feb 13, 2021·Infection and Drug Resistance·Yu WangHongxin Wang

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