ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases

The American Journal of Clinical Nutrition
Yan GongLois E Smith

Abstract

Neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration, threaten the visual health of children and adults. Current treatment options, including anti-vascular endothelial growth factor therapy and laser retinal photocoagulation, have limitations and are associated with adverse effects; therefore, the identification of additional therapies is highly desirable. Both clinical and experimental studies show that dietary ω-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFAs) reduce retinal and choroidal angiogenesis. The ω-3 LC-PUFA metabolites from 2 groups of enzymes, cyclooxygenases and lipoxygenases, inhibit [and the ω-6 (n-6) LC-PUFA metabolites promote] inflammation and angiogenesis. However, both of the ω-3 and the ω-6 lipid products of cytochrome P450 oxidase 2C promote neovascularization in both the retina and choroid, which suggests that inhibition of this pathway might be beneficial. This review summarizes our current understanding of the roles of ω-3 and ω-6 LC-PUFAs and their enzymatic metabolites in neovascular eye diseases.

Citations

Sep 6, 2019·EMBO Molecular Medicine·Zhongjie FuLois Eh Smith
Feb 13, 2020·Investigative Ophthalmology & Visual Science·Yuhang YangGuoming Zhang
Jan 8, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Mariela Bernabe-GarcíaLeonardo Cruz-Reynoso
Jul 25, 2019·Frontiers in Pharmacology·Ingrid Fleming
Sep 13, 2019·Journal of Diabetes Research·Olvera-Montaño CeciliaRodríguez-Carrizalez Adolfo Daniel
Jun 18, 2020·Antioxidants·Mong-Heng WangMohamed Al-Shabrawey
Apr 8, 2020·Oxidative Medicine and Cellular Longevity·Ricardo Raúl Robles-RiveraAdolfo Daniel Rodríguez-Carrizalez
Sep 18, 2018·Annual Review of Vision Science·Ye Sun, Lois E H Smith
Feb 23, 2019·Frontiers in Pharmacology·Bomina Park, Timothy W Corson
Nov 24, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Aditi A GodhamgaonkarSadhana R Joshi
May 8, 2021·Scientific Reports·Cayla D OntkoJohn S Penn
Jul 7, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chun-Lin ZhangYa-Nan Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.