Abstract
Neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration, threaten the visual health of children and adults. Current treatment options, including anti-vascular endothelial growth factor therapy and laser retinal photocoagulation, have limitations and are associated with adverse effects; therefore, the identification of additional therapies is highly desirable. Both clinical and experimental studies show that dietary ω-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFAs) reduce retinal and choroidal angiogenesis. The ω-3 LC-PUFA metabolites from 2 groups of enzymes, cyclooxygenases and lipoxygenases, inhibit [and the ω-6 (n-6) LC-PUFA metabolites promote] inflammation and angiogenesis. However, both of the ω-3 and the ω-6 lipid products of cytochrome P450 oxidase 2C promote neovascularization in both the retina and choroid, which suggests that inhibition of this pathway might be beneficial. This review summarizes our current understanding of the roles of ω-3 and ω-6 LC-PUFAs and their enzymatic metabolites in neovascular eye diseases.
Citations
Mar 9, 2018·Nutrients·Massimo Dal MontePaola Bagnoli
Dec 21, 2018·Cell Cycle·Luigi DonatoAntonina Sidoti
Sep 6, 2019·EMBO Molecular Medicine·Zhongjie FuLois Eh Smith
Feb 13, 2020·Investigative Ophthalmology & Visual Science·Yuhang YangGuoming Zhang
May 17, 2019·Lipids in Health and Disease·Aldo R Eynard, Gaston Repossi
Nov 8, 2018·Nutrients·Emanuele RinninellaAngelo Maria Minnella
Jan 8, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Mariela Bernabe-GarcíaLeonardo Cruz-Reynoso
Jul 25, 2019·Frontiers in Pharmacology·Ingrid Fleming
Sep 13, 2019·Journal of Diabetes Research·Olvera-Montaño CeciliaRodríguez-Carrizalez Adolfo Daniel
Apr 29, 2020·Exploration of Medicine·Lara Carroll, Leah A Owen
Nov 9, 2017·Journal of Cellular Physiology·Si ChenXiaolin Liu
Jun 18, 2020·Antioxidants·Mong-Heng WangMohamed Al-Shabrawey
Jul 28, 2019·Diabetologia·Stephanie EidPatrice E Fort
Apr 8, 2020·Oxidative Medicine and Cellular Longevity·Ricardo Raúl Robles-RiveraAdolfo Daniel Rodríguez-Carrizalez
Sep 18, 2018·Annual Review of Vision Science·Ye Sun, Lois E H Smith
Feb 23, 2019·Frontiers in Pharmacology·Bomina Park, Timothy W Corson
Apr 9, 2021·Frontiers in Endocrinology·Hussain RaoPeter Koulen
Nov 24, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Aditi A GodhamgaonkarSadhana R Joshi
Dec 29, 2020·Endocrine Journal·Takuro OkamuraMichiaki Fukui
May 8, 2021·Scientific Reports·Cayla D OntkoJohn S Penn
Jun 25, 2021·Advances in Nutrition·Zihao HuangChengquan Tan
Jul 7, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chun-Lin ZhangYa-Nan Li