ω-3 and folic acid act against depressive-like behavior and oxidative damage in the brain of rats subjected to early- or late-life stress

Nutrition
Gislaine Z RéusJoão Quevedo

Abstract

To investigate the antidepressant and antioxidant effects of omega-3, folic acid and n-acetylcysteine (NAC) in rats which were subjected to early or late life stress. Early stress was induced through maternal deprivation (MD), while late life stress was induced using the chronic mild stress (CMS) protocol. Young rats which were subjected to MD and the adult rats which were subjected to CMS were treated with omega-3 fatty acids (0.72 g/kg), NAC (20 mg/kg) or folic acid (50 mg/kg) once/day, for a period of 20 days. Then, the animals' immobility times were evaluated using the forced swimming test. Oxidative stress parameters were evaluated in the brain. Depressive-like behavior induced by CMS was prevented by NAC and folic acid, and depressive-like behavior induced by MD was prevented by NAC, folic acid and omega-3. NAC, folic acid and omega-3 were able to exert antioxidant effects in the brain of rats subjected to CMS or MD. These preventive treatments decreased the levels of protein carbonylation and lipid peroxidation, and also decreased the concentrations of nitrite/nitrate and reduced the activity of myeloperoxidase activity in the rat brain which was induced by CMS or MD. NAC, folic acid and omega-3 increased superoxide dism...Continue Reading

Citations

Jul 16, 2019·Current Opinion in Psychiatry·Jodi Zik, Steven Berkowitz
Feb 13, 2020·Journal of Clinical Medicine·Clarissa CataleValeria Carola
Jul 14, 2020·Experimental Brain Research·Luiza Martins Costa MalconRodrigo Grassi-Oliveira
Apr 5, 2019·Oxidative Medicine and Cellular Longevity·Gislaine Z RéusJoão Quevedo
Jun 30, 2019·The Proceedings of the Nutrition Society·Marion Rincel, Muriel Darnaudéry
Dec 24, 2018·Frontiers in Behavioral Neuroscience·Anke Hoffmann, Dietmar Spengler
Dec 29, 2020·Frontiers in Neuroscience·Janine Aly, Olivia Engmann
Mar 25, 2021·British Journal of Pharmacology·Irena SmagaMałgorzata Filip
Jul 3, 2021·International Journal of Molecular Sciences·Ariel FrajermanBoris Chaumette
Aug 7, 2021·Behavioural Brain Research·Josiane BudniAna Lúcia S Rodrigues

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