α-Adrenergic receptor regulation of skeletal muscle blood flow during exercise in heart failure patients with reduced ejection fraction

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Zachary Barrett-O'KeefeD Walter Wray

Abstract

Patients suffering from heart failure with reduced ejection fraction (HFrEF) experience impaired limb blood flow during exercise, which may be due to a disease-related increase in α-adrenergic receptor vasoconstriction. Thus, in eight patients with HFrEF (63 ± 4 yr) and eight well-matched controls (63 ± 2 yr), we examined changes in leg blood flow (Doppler ultrasound) during intra-arterial infusion of phenylephrine (PE; an α1-adrenergic receptor agonist) and phentolamine (Phen; a nonspecific α-adrenergic receptor antagonist) at rest and during dynamic single-leg knee-extensor exercise (0, 5, and 10 W). At rest, the PE-induced reduction in blood flow was significantly attenuated in patients with HFrEF (-15 ± 7%) compared with controls (-36 ± 5%). During exercise, the controls exhibited a blunted reduction in blood flow induced by PE (-12 ± 4, -10 ± 4, and -9 ± 2% at 0, 5, and 10 W, respectively) compared with rest, while the PE-induced change in blood flow was unchanged compared with rest in the HFrEF group (-8 ± 5, -10 ± 3, and -14 ± 3%, respectively). Phen administration increased leg blood flow to a greater extent in the HFrEF group at rest (+178 ± 34% vs. +114 ± 28%, HFrEF vs. control) and during exercise (36 ± 6, 37 ± 7, an...Continue Reading

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Citations

Dec 31, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jacqueline K LimbergJaume Padilla
Jun 22, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jesse C CraigDavid C Poole
Aug 22, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Joshua M BockDarren P Casey
Feb 27, 2021·Clinical Science·Catherine F Notarius, John S Floras
Dec 15, 2020·The Canadian Journal of Cardiology·Mark B BadrovJohn S Floras
May 19, 2021·Journal of Applied Physiology·Joel D TrinityRussell S Richardson
Mar 19, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Daniel A KeirJohn S Floras
Jul 15, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John S Floras
Jan 2, 2022·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Divya SomanJonathan R Lindner

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

Logiq
SigmaStat
Systat

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