α-Amylase- and Redox-Responsive Nanoparticles for Tumor-Targeted Drug Delivery

ACS Applied Materials & Interfaces
Yihui LiXiangliang Yang

Abstract

Paclitaxel (PTX) is an effective antineoplastic agent and shows potent antitumor activity against a wide spectrum of cancers. Yet, the wide clinical use of PTX is limited by its poor aqueous solubility and the side effects associated with its current therapeutic formulation. To tackle these obstacles, we report, for the first time, α-amylase- and redox-responsive nanoparticles based on hydroxyethyl starch (HES) for the tumor-targeted delivery of PTX. PTX is conjugated onto HES by a redox-sensitive disulfide bond to form HES-SS-PTX, which was confirmed by results from NMR, high-performance liquid chromatography-mass spectrometry, and Fourier transform infrared spectrometry. The HES-SS-PTX conjugates assemble into stable and monodispersed nanoparticles (NPs), as characterized with Dynamic light scattering, transmission electron microscopy, and atomic force microscopy. In blood, α-amylase will degrade the HES shell and thus decrease the size of the HES-SS-PTX NPs, facilitating NP extravasation and penetration into the tumor. A pharmacokinetic study demonstrated that the HES-SS-PTX NPs have a longer half-life than that of the commercial PTX formulation (Taxol). As a consequence, HES-SS-PTX NPs accumulate more in the tumor compared ...Continue Reading

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Citations

Oct 27, 2020·Advanced Materials·Xiaodong ZhangYanli Zhao
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shirin MollazadehMostafa Yazdimamaghani
Oct 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara Maslanka FigueroaAchim Goepferich
Apr 5, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tuying YongXiangliang Yang
Apr 3, 2021·Frontiers in Oncology·Marina Santiago FrancoMônica Cristina Oliveira
Feb 23, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qing ZhouXiangliang Yang
Jul 30, 2021·Advanced Science·Yuezhou ZhangWei Huang
Mar 4, 2020·ACS Central Science·Wenqi YuHuile Gao
Nov 13, 2021·ACS Applied Materials & Interfaces·Hao WangHan Zhang

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