β-Asarone Regulates ER Stress and Autophagy Via Inhibition of the PERK/CHOP/Bcl-2/Beclin-1 Pathway in 6-OHDA-Induced Parkinsonian Rats

Neurochemical Research
Baile NingYong-Qi Fang

Abstract

β-Asarone (1,2,4-trimethoxy-5-[(Z)-prop-1-enyl]benzene) is an essential component of Acorus tatarinowii Schott volatile oil. Previous research has observed that β-asarone effectively attenuated symptoms in parkinsonian rats and improved their performance, but the mechanism of this effect remains unclear. Other research has shown that endoplasmic reticulum (ER) stress plays an important role in the pathogenesis of Parkinson's disease (PD). The protein kinase RNA-like endoplasmic reticulum kinase (PERK) was observed in the nigrostriatal dopaminergic neurons of patients with PD. However, our group observed that ER stress and autophagy occurred in 6-hydroxy dopamine (6-OHDA)-induced parkinsonian rats, and ER stress might induce autophagy. We assume that the protective role of β-asarone in parkinsonian rats is mediated via the ER stress-autophagy pathway. To support this hypothesis, we investigated the expressions of glucose regulated protein 78 (GRP78), PERK phosphorylation (p-PERK), C/EBP homologous binding protein (CHOP), Bcl-2 and Beclin-1 in 6-OHDA-induced parkinsonian rats after β-asarone treatment. The results showed that the β-asarone group and PERK inhibitor group had lower levels of GRP78, p-PERK, CHOP and Beclin-1 while h...Continue Reading

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Citations

Jan 15, 2020·Current Pharmaceutical Design·Octavio Binvignat, Jordi Olloquequi
Sep 1, 2020·American Journal of Physiology. Endocrinology and Metabolism·Xiao Wen WangWen-Fang Chen
Mar 25, 2020·International Journal of Molecular Sciences·Wioletta Rozpędek-KamińskaIreneusz Majsterek
Apr 9, 2020·International Journal of Molecular Sciences·Thomas NuryAnne Vejux
Feb 6, 2020·Frontiers in Pharmacology·Nanbu WangRonghua Zhang
Oct 24, 2019·International Journal of Molecular Sciences·Bongki ChoYun-Il Lee
Feb 14, 2021·Journal of Chemical Neuroanatomy·Xiaohong WangXinqing Guo
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aswir Abd RashedDevi Nair Gunasegavan Rathi
Mar 24, 2021·Neurochemistry International·Rajat SandhirNitin Kumar Singhal
May 14, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Sicong LiXin Liu
Jun 26, 2021·Frontiers in Aging Neuroscience·Haigang RenGuanghui Wang

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Methods Mentioned

BETA
nuclear magnetic resonance
Protein Assay
electrophoresis
PCR
flow cytometry
protein folding

Software Mentioned

pro Plus
Image
SPSS
Quantity One

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