α-Asarone suppresses the proliferation and migration of ASMCs through targeting the lncRNA-PVT1/miR-203a/E2F3 signal pathway in RSV-infected rats

Acta Biochimica Et Biophysica Sinica
Xiao YuHong Fang

Abstract

Asthma is a chronic inflammatory pulmonary disease and respiratory syncytial virus (RSV) infection is a common cause of lower respiratory tract illness in infants and young children. α-Asarone presents many pharmacological effects and has been demonstrated to be useful in treating asthma. However, the functional mechanism of α-asarone in RSV-infected asthma has not been investigated. Long non-coding RNAs (lncRNAs) have been reported to play critical roles in many biological processes. Although many lncRNAs have been characterized, few were reported in asthma, especially in RSV-induced asthma. Currently, a novel post-transcriptional regulation has been proposed in which lncRNAs function as competing endogenous RNAs (ceRNAs) to competitively sponge miRNAs, thereby regulating the target genes. In the present study, we established an RSV-infected Sprague-Dawley rat model and demonstrated that lncRNA-PVT1 is involved in the mechanism of α-asarone in treating RSV-induced asthma, and lncRNA-PVT1 regulates the expression of E2F3 by functioning as a ceRNA which competitively sponges miR-203a.

References

Oct 18, 1995·JAMA : the Journal of the American Medical Association·D M MirvisW B Applegate
Jun 13, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J Hirst
Sep 6, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sundaramahalingam Manikandan, Rathinasamy Sheela Devi
May 16, 2007·Journal of Cellular Physiology·Letizia CarramusaSalvatore Feo
Dec 31, 2008·Pulmonary Pharmacology & Therapeutics·Jeremy A HirotaThai Tran
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Kecia N CarrollTina V Hartert
Jul 3, 2009·Genes & Development·Jeremy E WiluszDavid L Spector
Mar 26, 2011·Pediatric Pulmonology·Melvin Wright, Giovanni Piedimonte
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Sep 16, 2011·The Journal of Allergy and Clinical Immunology·Eleni TsitsiouMark A Lindsay
Jan 28, 2012·The European Respiratory Journal·Louis-Philippe BouletEric D Bateman
Jul 11, 2012·Pulmonary Pharmacology & Therapeutics·Behzad YeganehBrian G G Oliver
Oct 22, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y S Prakash
Jan 17, 2014·Nature·Yvonne TayPier Paolo Pandolfi
Jun 3, 2014·Respiratory Research·Mark M PerryKian Fan Chung
Jun 13, 2014·Journal of the Pediatric Infectious Diseases Society·Gabriel J EscobarTina Hartert
Jul 11, 2014·Chest·Richard Booton, Mark A Lindsay
Jan 24, 2015·Canadian Journal of Physiology and Pharmacology·Christine R KeenanAlastair G Stewart
Apr 13, 2015·The Journal of Allergy and Clinical Immunology·Helena PerssonCarsten O Daub
Apr 25, 2015·Molecular and Cellular Biochemistry·Hui CaiYong Gao
May 10, 2015·Biochemical and Biophysical Research Communications·Xian-wen ZhangJun Li
Jun 13, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José Luiz Marques-RochaAmelia Marti
Aug 9, 2015·Journal of Experimental & Clinical Cancer Research : CR·Weizhao PengRen Ma
Sep 13, 2015·Journal of Experimental & Clinical Cancer Research : CR·Jie DingKeming Wang
Apr 10, 2016·FEBS Letters·Lawrence O'LearyMark M Perry
Jun 28, 2017·Gynecologic Oncology·Alexander MelamedJohn O Schorge

❮ Previous
Next ❯

Citations

Nov 20, 2019·Heart Failure Reviews·Qi JinZhihong Liu
Oct 6, 2020·Frontiers in Pharmacology·Xueyi ZhuJingcheng Dong
Jan 26, 2021·Briefings in Functional Genomics·Partha ChattopadhyayRajesh Pandey
Jul 13, 2021·Reviews in Medical Virology·Mina Mobini KeshehSomayeh Shokri
Aug 25, 2021·Yonsei Medical Journal·Xiangying WangMeiling Sheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

TheScientificWorldJournal
Rituparno SenJayprokas Chakrabarti
Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association
Katherine A Poehling, Gerald B Hickson
American Journal of Respiratory and Critical Care Medicine
Shawn Monique CastroAntonella Casola
© 2022 Meta ULC. All rights reserved