▼ Bezlotoxumab for prevention of recurrence of Clostridium difficile infection

Drug and Therapeutics Bulletin

Abstract

Clostridium difficile infection is a significant cause of infectious diarrhoea and is associated with considerable morbidity and mortality.1,2 Management of Clostridium difficile infection often requires treatment with antibiotics (metronidazole, vancomycin or fidaxomicin) alongside supportive care to manage hydration, electrolytes and nutrition. However, the risk of recurrence is approximately 20%.2 Here, we review the evidence for bezlotoxumab (▼ Zinplava - Merck Sharp & Dohme Limited), a monoclonal antibody licensed for the prevention of recurrence of Clostridium difficile in adults who are at high risk of recurrence.

References

May 8, 2004·The Journal of Hospital Infection·UNKNOWN National Clostridium difficile Standards Group
Feb 4, 2011·The New England Journal of Medicine·Thomas J LouieUNKNOWN OPT-80-003 Clinical Study Group
Dec 21, 2011·Annals of Internal Medicine·Dimitri M DrekonjaTimothy J Wilt
Jun 5, 2015·Deutsches Ärzteblatt International·Jürgen Stausberg
Jun 16, 2016·Journal of Pain & Palliative Care Pharmacotherapy· Food And Drug Administration Public Health Service U S Department Of Health And Human Services
Jan 26, 2017·The New England Journal of Medicine·Mark H WilcoxUNKNOWN MODIFY I and MODIFY II Investigators
Nov 4, 2017·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroshige MikamoTomoko Yoshinari
Jul 5, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America

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