β-Blocker use and mortality in cancer patients: systematic review and meta-analysis of observational studies

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Shanliang ZhongShukui Wang

Abstract

A number of epidemiologic studies have attempted to link the use of β blockers to mortality in cancer patients, but their findings have been inconclusive. A meta-analysis was carried out to derive a more precise estimation. Relevant studies were identified by searching PubMed and EMBASE to May 2015. We calculated the summary hazard ratios (HRs) and 95% confidence intervals (CIs) using random-effects models. Twenty cohort studies and four case-control studies involving 76 538 participants were included. The overall results showed that patients who used β blockers after diagnosis had an HR of 0.89 (95% CI 0.81-0.98) for all-cause mortality compared with nonusers. Those who used β blockers after diagnosis (vs. nonusers) had an HR of 0.89 (95% CI 0.79-0.99) for cancer-specific mortality. Prediagnostic use of β blockers showed no beneficial effect on all-cause mortality or cancer-specific mortality. Stratifying by cancer type, only breast cancer patients who used β blockers after diagnosis had a prolonged overall survival. A linear but nonsignificant trend was found between postdiagnostic β-blocker use and mortality of cancer patients. In conclusion, the average effect of β-blocker use after diagnosis but not before diagnosis is ben...Continue Reading

References

Jun 1, 1992·American Journal of Epidemiology·S Greenland, M P Longnecker
Mar 6, 1993·BMJ : British Medical Journal·D J HoleA F Lever
Mar 6, 1993·BMJ : British Medical Journal·A E FletcherJ Webster
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
May 5, 2007·BMJ : British Medical Journal·H T Ong
Feb 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Henrike E Karim-KosJan Willem W Coebergh
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Mar 17, 2010·BMJ : British Medical Journal·Linda E LévesqueSamy Suissa
Feb 12, 2011·BMJ : British Medical Journal·Richard D RileyJonathan J Deeks
Jun 3, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amal Melhem-BertrandtAna-Maria Gonzalez-Angulo
Jun 3, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas I BarronKala Visvanathan
Sep 22, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stanley LemeshowRonald Glaser
Oct 18, 2011·The Breast : Official Journal of the European Society of Mastology·Mehmet Ali Nahit SendurKadri Altundag
May 17, 2012·Clinical Cardiology·Syed Wamique YusufIyad N Daher
Jul 24, 2012·Gynecologic Oncology·Elena S DiazAndrew J Li
Jan 10, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H M WangD R Gomez
Aug 6, 2013·Breast Cancer Research and Treatment·Edoardo BotteriSara Gandini
Aug 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E LivingstoneE de Vries
Sep 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B M HicksC R Cardwell
Nov 5, 2013·Mayo Clinic Proceedings·Vincenzo De GiorgiPierangelo Geppetti
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Adnan AydinerLeyla Kilic
Feb 1, 2014·Journal of Clinical Anesthesia·Juan P CataVijaya Gottumukkala
Mar 19, 2014·Leukemia & Lymphoma·Young Kwang ChaeMichael Andreeff
May 24, 2014·European Journal of Epidemiology·Shanliang ZhongJianhua Zhao
Sep 2, 2014·The Journal of Investigative Dermatology·Ludovic J Wrobel, Frederique Anne Le Gal
Sep 11, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jonathan AssayagLaurent Azoulay
Dec 3, 2014·International Journal of Cardiology·Martin C S WongAndrew J S Coats
May 23, 2015·Chemotherapy·Minas SakellakisAngelos Koutras

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Citations

Oct 15, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Marisa CoelhoMarco Cosentino
Aug 15, 2019·International Journal of Environmental Research and Public Health·Yu-Jin KwonJi-Won Lee
Sep 22, 2018·Anti-cancer Drugs·Rashek Kazi, Yuri L Bunimovich
Dec 7, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carlo FumagalliDiego Fornasari

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