ß-Blockers reduce mortality in patients undergoing high-risk non-cardiac surgery

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Fabio AngeliGianpaolo Reboldi

Abstract

ß-Adrenergic receptor antagonists (beta-blockers) are frequently used with the aim of reducing perioperative myocardial ischemia and infarction. However, randomized clinical trials specifically designed to evaluate the effects of beta-blockers on mortality in patients undergoing non-cardiac surgery have yielded conflicting results. This study aimed to examine the effect of perioperative ß-blockers on total and cardiovascular mortality in patients undergoing non-cardiac surgery. We conducted a meta-analysis of randomized clinical trials that examined the effects of ß-blockers versus placebo on cardiovascular and all-cause mortality in patients undergoing non-cardiac surgery. We extracted data from articles published before 30 November 2009 in peer-reviewed journals indexed in MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE and CINAHL. Data extraction was carried out independently by two reviewers on the basis of an intent-to-treat approach, and inconsistencies were discussed and resolved in conference. The present meta-analysis was undertaken according to the Quality of Reporting of Meta-analyses (QUORUM) statement. A total of 2148 records were screened, from which we identified 74 randomized controlled...Continue Reading

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Citations

Dec 1, 2011·Journal of Bioenergetics and Biomembranes·Erkan TuncayBelma Turan
Feb 18, 2012·British Journal of Anaesthesia·P Foex, J W Sear
Sep 8, 2011·Journal of Anaesthesiology, Clinical Pharmacology·P N KakarJyotirmoy Das
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May 26, 2011·Expert Opinion on Drug Safety·Fabio AngeliPaolo Verdecchia
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Jun 26, 2020·Expert Opinion on Pharmacotherapy·Fabio AngeliGianpaolo Reboldi

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