(‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Marialuisa FormatoSeverina Pacifico

Abstract

Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp (Cannabis sativa L.) plants, but its potential health-related capabilities have been masked for years by a greater scientific interest towards its neutral derivative cannabidiol (CBD). This review aims to collect from the literature and critically discuss all the information about this molecule, starting from its biosynthesis, and focusing on its bioactivity, as an anti-inflammatory, anti-emetic, anti-convulsant, and anti-cancerogenic drug. Furthermore, in the awareness that, despite its multiple bioactive effects, currently poor efforts have been made to achieve its reliable purification, herein, we propose a relatively simple, fast, and inexpensive procedure for its recovery from pollen of industrial hemp cultivars. Spectroscopic and spectrometric techniques allowed us to unequivocally identify pure isolated CBDA and to distinguish it from the constitutional isomer tetrahydrocannabinolic acid (THCA-A).

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Citations

Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luana IzzoAlberto Ritieni
Aug 23, 2020·Foods·Simona PiccolellaSeverina Pacifico
Dec 3, 2020·International Journal of Molecular Sciences·Fatema Yeasmin, Hyong Woo Choi
May 15, 2021·Journal of Pharmaceutical and Biomedical Analysis·Simona PiccolellaSeverina Pacifico
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ersilia NigroAurora Daniele
Jul 1, 2021·Journal of Gerontological Nursing·Brooke PorterKeela Herr
Aug 28, 2021·Journal of Animal Physiology and Animal Nutrition·Alessandro VastoloMonica Isabella Cutrignelli
Dec 7, 2021·ACS Omega·Xiaoyan ChenJiangnan Peng

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Software Mentioned

CBDA
Molinspiration Cheminformatics
PubChem

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