PMID: 9438556Jan 23, 1998Paper

(+)-Catechin prevents human plasma oxidation

Free Radical Biology & Medicine
S B Lotito, C G Fraga

Abstract

Based on the recognized capacity of (+)-catechin (CTCH) to prevent free radical-mediated damage in different biological systems, its role in the protection of human plasma from oxidation was investigated. Samples of human blood plasma were incubated with 50 mM AAPH [2,2'-azobis-(2-amidinopropane) clorhidrate] or AMVN [2,2'-azobis(2,4-valeronitrile)], in the absence or the presence of CTCH (0.01 to 1 mM). Lipid oxidation was evaluated measuring the formation of 2-thiobarbituric acid reactive substances (TBARS). Alpha-tocopherol (AT), beta-carotene (BC), and CTCH were measured by reverse phase HPLC with electrochemical detection. TBARS formation was dependent on incubation time and on the nature of the azocompound, yielding 4.8 +/- 0.9, and 14.9 +/- 3.4 microM MDA, after 4 h, in AAPH and AMVN-exposed plasma, respectively. Plasma AT and BC were extensively depleted under these oxidant conditions. The addition of CTCH prevented or delayed the formation of TBARS, and the depletion of AT and BC in a dose dependent manner. This antioxidant effect was dependent on the concentration of CTCH and on the physical characteristics of the radical initiator. CTCH supplementation modified not only the lag time for the antioxidants depletion, bu...Continue Reading

References

Jan 1, 1990·Free Radical Biology & Medicine·Y T ChenY Ju
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Jan 1, 1987·Free Radical Research Communications·W Bors, M Saran
Mar 1, 1987·Biochemical Pharmacology·C G FragaA Boveris
Apr 1, 1995·Free Radical Research·C A Rice-EvansJ B Pridham
Jun 1, 1994·Free Radical Biology & Medicine·Y HanasakiS Fukui
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
May 20, 1993·The New England Journal of Medicine·E B RimmW C Willett
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·G D Stoner, H Mukhtar
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Jan 1, 1996·Journal of the American Optometric Association·E Cheraskin

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Citations

Oct 12, 2000·Biochemical and Biophysical Research Communications·S B LotitoC G Fraga
Dec 28, 2011·Analytical and Bioanalytical Chemistry·Myalowenkosy I SabelaSalvador Sagrado
Jan 28, 2004·Free Radical Biology & Medicine·Silvina B Lotito, Balz Frei
Nov 4, 2000·Atherosclerosis·J RuidavetsJ Cabanis
Aug 12, 2000·Free Radical Biology & Medicine·J PengK Watson
Dec 21, 2000·Free Radical Biology & Medicine·A GhiselliC Scaccini
Oct 26, 2001·Free Radical Biology & Medicine·G AldiniN I Krinsky
Dec 25, 2002·Free Radical Biology & Medicine·Sandra V VerstraetenPatricia I Oteiza
Jan 29, 2003·The Journal of Nutritional Biochemistry·Francene M. SteinbergCarl L. Keen
Mar 10, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K OsadaM Sugano
May 25, 2007·The British Journal of Nutrition·D LópezM T Mitjavila
Sep 21, 2000·Proceedings of the Society for Experimental Biology and Medicine·S B Lotito, C G Fraga
Aug 25, 2011·Journal of Medicinal Food·Florinda FratianniFilomena Nazzaro
Feb 15, 2001·Current Opinion in Lipidology·B Fuhrman, M Aviram
Aug 25, 2009·Journal of Cardiovascular Pharmacology·Monica GalleanoCesar G Fraga
Jun 21, 2002·Annals of the New York Academy of Sciences·Lucas Actis-GorettaCésar G Fraga
Jun 21, 2002·Annals of the New York Academy of Sciences·Silvina B LotitoCésar G Fraga
Jan 12, 2001·The American Journal of Chinese Medicine·Y C HsuJ C Chen
Jul 16, 2005·Annals of Nutrition & Metabolism·Vijayakumar C ReddyM Raghunath
Sep 13, 2002·Bioscience, Biotechnology, and Biochemistry·Chikako MurakamiHiromi Yoshida
Apr 25, 2007·Critical Reviews in Food Science and Nutrition·Wilailuk ChaiyasitEric A Decker
May 28, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jitender MongaManu Sharma
Jun 24, 2003·Phytotherapy Research : PTR·S C SharmaO P Gulati
Feb 14, 2013·Fish & Shellfish Immunology·Hangjun ZhangXiuying Jia
Oct 7, 2005·International Journal of Dermatology·Cheryl BansalClay J Cockerell
Apr 8, 2010·Cardiovascular Therapeutics·Tinoy J Kizhakekuttu, Michael E Widlansky
Aug 20, 2005·Free Radical Biology & Medicine·Kazuo MukaiKeishi Ohara
Mar 4, 2015·Biotechnology Advances·Rakshit K DevappaRobert F H Dekker

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