β-Catenin-Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding

Plastic and Reconstructive Surgery
Antoine L CarreH Peter Lorenz

Abstract

Acute wound healing is a dynamic process that results in the formation of scar tissue. The mechanisms of this process are not well understood; numerous signaling pathways are thought to play a major role. Here, the authors have identified β-catenin-dependent Wnt signaling as an early acute-phase reactant in acute wound healing and scar formation. The authors created 6-mm full-thickness excisional cutaneous wounds on adult β-catenin-dependent Wnt signal (BAT-gal) reporter mice. The expression of canonical Wnt after wounding was analyzed using X-gal staining and quantitative real-time polymerase chain reaction. Next, recombinant mouse Wnt3a (rmWnt3a) was injected subcutaneously to the wound edge, daily. The mice were killed at stratified time points, up to 15 days after injury. Histologic analysis, quantitative real-time polymerase chain reaction, and Western blot were performed. Numerous individual Wnt ligands increased in expression after wounding, including Wnt3a, Wnt4, Wnt10a, and Wnt11. A specific pattern of Wnt activity was observed, localized to the hair follicle and epidermis. Mice injected with rmWnt3a exhibited faster wound closure, increased scar size, and greater expression of fibroblast growth factor receptor-2 and t...Continue Reading

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Citations

Nov 7, 2019·Connective Tissue Research·Joanna BukowskaBarbara Gawronska-Kozak
Apr 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sungjoo ParkSun Chang Kim
Jul 12, 2020·Journal of Cutaneous Pathology·Keisuke GotoTakashi Sugino
Aug 26, 2021·Medicinal Research Reviews·Michelle F GriffinMichael T Longaker

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