β-cell dedifferentiation in diabetes is important, but what is it?

Islets
Gordon C WeirSusan Bonner-Weir

Abstract

This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene expression as well as in structural and functional elements. Thus, a fully mature healthy β cell will have its unique differentiation characteristics, but maturing cells and old β cells will have different patterns of gene expression and might therefore be considered as dedifferentiated. The meaning of dedifferentiation is now being debated because β cells in the diabetic state lose components of their differentiated state, which results in severe dysfunction of insulin secretion. The major cause of this change is thought to be glucose toxicity (glucotoxicity) and that lowering glucose levels with treatment results in some restoration of function. An issue to be discussed is whether dedifferentiated β cells return to a multipotent precursor cell phenotype or whether they follow a different pathway of dedifferentiation.

References

Sep 1, 1976·The Journal of Clinical Investigation·J P PalmerJ W Ensinck
Feb 11, 1976·The Journal of Clinical Endocrinology and Metabolism·J D BrunzellD Porte
Jun 1, 1983·The Journal of Clinical Investigation·S Bonner-WeirG C Weir
Oct 1, 1984·The Journal of Clinical Investigation·W K WardD Porte
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Feb 16, 1996·The Journal of Biological Chemistry·B D BennettD W Piston
Jun 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A AnderssonC Hellerström
Jan 10, 2002·The Journal of Biological Chemistry·D Ross LaybuttGordon C Weir
Dec 28, 2002·Diabetes·Alexandra E ButlerPeter C Butler
Nov 25, 2004·Diabetes·Gordon C Weir, Susan Bonner-Weir
Sep 8, 2006·Nature·Janakiraman KrishnamurthyNorman E Sharpless
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna
May 2, 2009·Molecular Endocrinology·Takuma KondoArun Sharma
Nov 26, 2010·Islets·Timothy J PullenGuy A Rutter
Dec 31, 2010·Diabetologia·C Aguayo-MazzucatoS Bonner-Weir
Feb 1, 2013·Annals of the New York Academy of Sciences·Gordon C Weir, Susan Bonner-Weir
May 8, 2013·The Journal of Cell Biology·Albert R DavalosJudith Campisi
Jul 19, 2013·The Journal of Clinical Investigation·Shuangli GuoRoland Stein
Oct 17, 2013·American Journal of Physiology. Endocrinology and Metabolism·Caroline Kaercher KramerRavi Retnakaran

❮ Previous
Next ❯

Citations

Jan 7, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mingfeng ZhangDefu Zeng
Apr 29, 2015·Experimental Animals·Ahmed M AbdellatifSatoru Takahashi
Dec 30, 2014·Molecular Aspects of Medicine·Emilyn U AlejandroErnesto Bernal-Mizrachi
Mar 31, 2015·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·R B OliveiraC B Collares-Buzato
May 20, 2015·BMC Biology·James Cantley, Frances M Ashcroft
Feb 28, 2015·Molecular Aspects of Medicine·Anmar Khadra, Santiago Schnell
Jul 15, 2016·Diabetologia·Adriana MiglioriniHeiko Lickert
Mar 15, 2016·Shock·Susan J BurkeJ Jason Collier
Sep 13, 2016·Diabetes, Obesity & Metabolism·M F BreretonF M Ashcroft
Nov 25, 2016·Nature Communications·Melissa F BreretonFrances M Ashcroft
Mar 29, 2016·Royal Society Open Science·Marta SzabatJames D Johnson
Apr 6, 2017·Cell Metabolism·Cristina Aguayo-MazzucatoSusan Bonner-Weir
Mar 6, 2018·The Journal of Clinical Investigation·Matthew RiopelYun Sok Lee
Mar 14, 2018·Cell Death Discovery·Adrian Keong Kee TeoHwee Hui Lau
Dec 6, 2017·The Journal of Endocrinology·Mohammed BensellamD Ross Laybutt
Nov 2, 2019·International Journal of Molecular Sciences·Ciro SalinnoMostafa Bakhti
Aug 8, 2018·The Journal of Clinical Endocrinology and Metabolism·Jiajun SunQidi Wang
Sep 28, 2018·Clinical Proteomics·Bhaswati Chatterjee, Suman S Thakur
Jan 5, 2017·Journal of Diabetes Research·Guoguang NiuShay Soker
Dec 8, 2016·Diabetes Care·Michael G WhiteRoy Taylor
Aug 12, 2019·Current Diabetes Reports·Abu Saleh Md Moin, Alexandra E Butler
Aug 11, 2019·Current Diabetes Reports·Ashley A Christensen, Maureen Gannon
Mar 18, 2020·The Journal of Clinical Investigation·Neha ShresthaLing Qi
Aug 17, 2019·Journal of Molecular Biology·Gabriela Da Silva Xavier, Guy A Rutter
Feb 16, 2021·American Journal of Physiology. Endocrinology and Metabolism·Mario A MirandaHeather A Lawson
Feb 11, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jiangman LiuJingshan Shi
Jan 21, 2021·International Journal of Molecular Sciences·Giuseppina Emanuela GriecoFrancesco Dotta

❮ Previous
Next ❯

Methods Mentioned

BETA
pancreatectomy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Sweta RaniLorraine O'Driscoll
Journal of Proteomics
Yannick BrunnerJean-Charles Sanchez
Annals of the New York Academy of Sciences
Gordon C Weir, Susan Bonner-Weir
© 2021 Meta ULC. All rights reserved